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Tissue Adhesions

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Pathological processes consisting of the union of the opposing surfaces of a wound.

Also Known As:

Adhesions, Tissue; Surgery-Induced Tissue Adhesions; Surgical Adhesions; Adhesion, Surgery-Induced Tissue; Adhesion, Surgical; Adhesion, Tissue; Adhesions, Surgery-Induced Tissue; Adhesions, Surgical; Surgery Induced Tissue Adhesions; Surgery-Induced Tissue Adhesion; Surgical Adhesion; Tissue Adhesion; Tissue Adhesion, Surgery-Induced; Tissue Adhesions, Surgery-Induced

Networked: 257 relevant articles (14 outcomes, 24 trials/studies)

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Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 4357
  - Fibrosis: 52099
    - Cicatrix: 19318
      - Tissue Adhesions: 257

Related Diseases

1.	Cicatrix (Scar)
2.	Wounds and Injuries (Trauma)
3.	Hemorrhage
4.	Inflammation
5.	Tissue Adhesions

Experts

1.	Lee, Jin Ho: 4 articles (09/2012 - 02/2005)
2.	Oh, Se Heang: 4 articles (09/2012 - 02/2005)
3.	Li, Fengfeng: 3 articles (12/2014 - 05/2009)
4.	Fan, Cunyi: 3 articles (12/2014 - 05/2009)
5.	Shin, Yong Cheol: 2 articles (08/2015 - 01/2014)
6.	Lee, Jong Ho: 2 articles (08/2015 - 01/2014)
7.	Yang, Won Jun: 2 articles (08/2015 - 01/2014)
8.	Cui, Wenguo: 2 articles (12/2014 - 02/2013)
9.	Cho, Woo Kyung: 2 articles (04/2014 - 01/2013)
10.	Karp, Jeffrey M: 2 articles (04/2014 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tissue Adhesions:

1.	alginic acid (sodium alginate)IBA 01/01/2010 - "In this study, we focused on alginate as a physical tissue adhesion barrier material. " 01/01/2010 - "From these observations, the un-cross-linked alginate film is expected to be a simple and efficient tissue adhesion barrier applicable to various injury tissues." 01/01/2010 - "We hypothesized that the alginate film without cross-linking can be a good candidate as a tissue adhesion barrier. " 01/01/2010 - "Alginate film as a novel post-surgical tissue adhesion barrier." 01/01/2010 - "From the animal study, it was observed that the un-cross-linked alginate film was more effective for the prevention of peritoneal tissue adhesion than other types of alginates, including the commercialized one, probably owing to its unique muco-adhesive property (providing residence stability without suturing at the injured site) and lubricant property (by hydration in contact with body fluid) during wound healing. "
2.	Ibuprofen (Motrin)FDA LinkGeneric 03/01/2005 - "Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. " 02/01/2013 - "In a chicken model of flexor digitorum profundus tendon surgery, the ibuprofen-loaded PELA fibrous membranes prevented tissue adhesion and significantly reduced inflammation. " 02/01/2005 - "It was observed that the ibuprofen-containing PLLA-PEG films with high PEG composition (particularly PLLA113-PEG113 film with PEG composition, 50 mol%) were very effective in preventing cell or tissue adhesion on the film surfaces, probably owing to the synergistic effects of highly mobile, hydrophilic PEG and anti-inflammatory drug, ibuprofen." 02/01/2005 - "This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postsurgical tissue adhesion. " 03/01/2005 - "The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel."
3.	polylactic acid-polyglycolic acid copolymer (PLGA)IBA 01/01/2014 - "Macroscopic observation after 1 week of surgical treatment revealed that the antiadhesion efficacy of E-PLGA nanofiber membranes was significantly superior to those of untreated controls and pure PLGA equivalents, which was comparable to that of a commercial tissue-adhesion barrier. " 08/01/2015 - "In this study, EGCG-loaded poly(lactic-co-glycolic acid) (PLGA) sheets were prepared by electrospinning nanofibers and evaluating their potential as tissue-adhesion barriers. " 11/01/2014 - "The multiscale patterned PLGA patches were highly flexible and showed higher tissue adhesion to the underlying tissue than did the single nanopatterned patches. " 08/01/2015 - "In conclusion, our study findings suggest that E-PLGA fibrous sheets may be exploited as potential tissue-adhesion barriers for the prevention of post-surgical adhesion formation." 12/01/1998 - "Gelation and tissue adhesion of mixtures of gelatin and poly (L-glutamic acid) (PLGA) aqueous solution were investigated in the presence of additives following the addition of a water-soluble carbodiimide (WSC) that induced chemical cross linking between gelatin and PLGA. "
4.	AlginatesIBA 07/01/2011 - "In the in vivo study, a rat surgical adhesion model was used to study the properties of the alginates, and the rats were euthanized on day 14 after surgery. " 01/01/2010 - "From the animal study, it was observed that the un-cross-linked alginate film was more effective for the prevention of peritoneal tissue adhesion than other types of alginates, including the commercialized one, probably owing to its unique muco-adhesive property (providing residence stability without suturing at the injured site) and lubricant property (by hydration in contact with body fluid) during wound healing. "
5.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 10/01/2015 - "LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. " 09/01/1999 - "Use of fibrin adhesive to reduce post-surgical adhesion reformation in rabbits." 05/01/1999 - "Fibrinolytic activity of urine may rapidly degrade fibrin glue used in the urinary tract, thereby limiting tissue adhesion. " 01/01/1998 - "Fibrin glue (FG) is an agent widely used in many surgical disciplines for achieving hemostasis and tissue adhesion. " 07/01/1996 - "With earlier and more exuberant fibrous response and initial tissue adhesion from the fibrin adhesive, better stability will be established to allow for primary healing of meniscal tissues. "
6.	HydrogelsIBA 12/01/2007 - "Thermal gelation and tissue adhesion of biomimetic hydrogels." 01/01/2007 - "The tissue adhesion of the PIC hydrogels was evaluated with a dura incision model. " 09/01/2012 - "The HA/mcALG hydrogel was highly effective for the prevention of peritoneal tissue adhesion compared to HA and mcALG hydrogels, and did not lead to any abnormal tissue responses during wound healing. " 10/01/2013 - "Benefiting from the fast gelation behaviors, desirable mechanical properties, relatively high adhesive performance and no cytotoxicity, these hydrogels have the potential applications as promising biomaterials for tissue adhesion and sealing." 09/01/2014 - "The incorporation of different concentrations of polymeric nanocapsule suspensions into chitosan hydrogels is proposed, in order to study the structure of a formulation with the properties of great tissue adhesion and controlled release of the nanoencapsulated drugs, represented here by capsaicinoids. "
7.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 09/01/2009 - "It was observed that the PELA copolymer membrane was very effective in preventing cell or tissue adhesion on the membrane surface, probably owing to the effects of hydrophilic polyethylene glycol." 02/01/2005 - "This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postsurgical tissue adhesion. " 08/01/2008 - "To develop a chitosan (CH)/polyethylene glycols succinate acid (PEG-SA)-mediated mitomycin C (MMC) delivery system and investigate its drug release characteristics in vitro and its effect against scar tissue adhesion in vivo. "
8.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/01/2004 - "Preoperative GnRH-a is more effective than Interceed in preventing surgical adhesions in the rabbit uterine horn. " 08/01/2014 - "New drugs for the medical treatment of endometriosis targeting both hormonal (GnRH, estrogen and progesterone receptors) and nonhormonal pathways (inflammation, angiogenesis, adhesions, tissue invasion) are promising, but their efficacy and safety need to be established in randomized human trials before they can be used in clinical practice."
9.	poly(lactide) (polylactide)IBA 05/01/2009 - "Hydrosorb Shield appears to be an effective postoperative barrier to scar tissue adhesion after anterolateral discectomy. " 03/01/2007 - "In this study, the bilayered composite membrane formed by the association of a methoxy poly (ethylene glycol)-poly (L-lactide-co-glycolide) (mPEG-PLGA) film and a crosslinked collagen-hyaluronic acid (Col-HA) membrane with fibronectin (FN) coating was prepared for promoting wound healing and providing tissue adhesion resistance simultaneously. "
10.	HydrogelIBA 05/01/2007 - "XL application may have attenuated tissue adhesion by forming a viscous hydrogel over the injured surfaces." 09/01/1999 - "All these findings suggest cross-linked hyaluronate hydrogel may be a valuable anti-adhesion material to prevent post-surgical adhesion in abdominal or pelvic surgery." 09/01/1999 - "The effect of cross-linked hyaluronate hydrogel on the reduction of post-surgical adhesion reformation in rabbits." 04/29/2013 - "Taken together, these results suggest that the gel's adequate viscoelastic properties and porous microstructure, combined with its tissue adhesion and neuritotrophic characteristics in the presence of a cell type-specific cytostatic, may constitute an appropriate hydrogel implant applicable to patients suffering from prostatectomy associated side effects." 09/01/2012 - "The HA/mcALG hydrogel can be a good candidate as an injectable tissue adhesion barrier for clinical applications."

Therapies and Procedures

1.	Injections 06/01/2009 - "This reduced hydrophilicity explains the poor attachment of fibroblast cells to the injectable PHBHHx film, suggesting that the PHBHHx injectable implant system can be developed as a tissue adhesion prevention film for surgical operations." 09/01/2012 - "The HA/mcALG hydrogel can be a good candidate as an injectable tissue adhesion barrier for clinical applications." 06/01/2009 - "Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as an injectable implant system for prevention of post-surgical tissue adhesion." 02/01/1999 - "The new poly(ether carbonate)s may be used in medical applications such as injectable drug delivery formulations and bioresorbable barriers for the prevention of surgical adhesions." 09/01/2012 - "Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier."
2.	Diskectomy (Discectomy) 05/01/2009 - "Hydrosorb Shield appears to be an effective postoperative barrier to scar tissue adhesion after anterolateral discectomy. "
3.	Sutures (Suture) 04/01/2012 - "Revision rotator cuff repair is made technically more difficult by poor tissue quality, tissue adhesions, and retained suture and suture anchor material. " 05/15/1982 - "2. The flat tissue adhesion without surgical suture, mainly used in fixation of skin transplants. " 05/15/1994 - "Fibrin glue is valuable in tissue synthesis and tissue adhesion, particularly where conventional suture methods would be difficult. " 11/01/1992 - "Human fibrin glue (Tissucol) was employed either as haemostatic agent, widely spread over the suture lines or as tissue adhesion agent between dissected aortic layers. " 07/01/2005 - "Spleen preservation and concomitant treatment of excessive hemorrhage were achieved by highly controlled "conic" compression of injuried spleen parenchyma, additional hemostatic Z-sutures and fibrin tissue adhesion. "
4.	Laparotomy 01/01/2010 - "This trial aims to assess, whether the intra-peritoneal application of A-Part Gel is safe and efficacious in the prevention of post-surgical adhesions after median laparotomy, in comparison to untreated controls." 10/01/1996 - "Laparotomy should be reserved for malignant adhesions, surgical misadventure, or when the pathology dictates." 01/01/2000 - "Surgical adhesions were induced by monopolar cautery on the right uterine horn through laparotomy and were then scored on day 21 after surgery. "
5.	Cesarean Section (Caesarean Section) 09/01/2006 - "The aim of this study was to compare the frequency of post-surgical adhesion among patients with closed or open peritoneal repair in the subsequent cesarean sections. " 11/01/2015 - "Reply to: "cesarean section and tissue adhesions"." 11/01/2015 - "Cesarean section and tissue adhesions."