Adenoviridae Infections (Adenovirus Infections)

01/01/2013 - "The efficacy of commonly used drugs to treat adenovirus infections (i.e., cidofovir in most cases) is limited, and alternative treatment options are needed. "
07/01/1996 - "Cidofovir proved to have potent antiviral activity against adenovirus replication and may have great promise for the treatment of adenovirus infection. "
03/01/2001 - "Further studies in immunocompromised patients will be needed to extend these promising results concerning the role of cidofovir in adenovirus infection."
01/01/2010 - "Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration. "
07/01/2002 - "The use of cidofovir in severe adenovirus infection has been limited by adverse effects, the most significant of which is nephrotoxicity. "

01/01/2005 - "If our in vitro findings are predictive of virological responses in vivo, these results suggest that ribavirin would not be effective for management of non-C species adenovirus infections after HSCT."
09/01/2009 - "The work results prove that the therapeutic effect of ribamydil (ribavirin) under treatment of adenovirus infections may be achieved in case when it is used in a dose excluding the expression of the adenovirus genome."
11/01/1995 - "Intravenous ribavirin therapy for disseminated adenovirus infection."
01/01/2004 - "In conclusion, the possible efficacy of intravenous Ribavirin in controlling RSV or adenovirus infections after allogeneic stem cell transplantations should be evaluated in prospective clinical trials."
03/01/1991 - "We conclude that controlled clinical trials of intravenous ribavirin therapy for serious adenovirus infections following bone marrow transplantation are warranted."

01/01/2010 - "(2) Diagnostic accuracy in adenovirus infection could be improved by selection of patient prior to antigen detection test based on detailed history, local epidemic situation and actively performed blood test. "
05/01/1967 - "A quantitative immunofluorescent procedure for detection of viral antigen was used to study the potentiation of AAV-1 by Ad.7. AAV viral antigen formed only when the cells were also infected with adenovirus, and only in cell culture systems in which the adenovirus infection proceeded to completion. "
11/01/2010 - "In conclusion, molecular methods were found to be useful for rapid diagnosis of adenovirus infections with higher sensitivity than antigen detection; their introduction permitted a significant increase in diagnoses of adenovirus infections."
01/01/2010 - "[Adenovirus infection and rapid adenovirus antigen detection kits]."
01/01/2009 - "Instead, intrahepatic antigen recognition limits the generation of potent anti-viral responses at both priming and effector stages of the CD8(+) T cell response and accounts for the dysfunctional CD8(+) T cell response observed during IV adenovirus infection. "

01/01/2006 - "However the efficiency of adenovirus infection can be greatly improved by a limited enzyme digestion, which makes accessible the lateral faces of cells bearing the Coxsackie and Adenovirus Receptor. "
06/01/2015 - "Expression of an engineered soluble coxsackievirus and adenovirus receptor by a dimeric AAV9 vector inhibits adenovirus infection in mice."
03/01/2015 - "Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?"
01/01/2015 - "The localization of their receptors coxsackievirus and adenovirus receptor, and desmoglein-2 in cell-cell junction complexes between polarized epithelial cells represents a major challenge for adenovirus infection from the apical surface. "
03/06/2014 - "Coxsackie and adenovirus receptor (CAR) is essential for adenovirus infection to target cells, and its constitutive expression in various cancerous and normal tissues has been reported. "

01/01/2000 - "Recent advances in adeno-associated virus (AAV) vector production have eliminated the need for adenovirus infection by transfection of plasmids encoding the adenovirus E2A, E4orf6, and VA RNA transcription units. "
12/01/1989 - "These EVA cell lines may be of use to study the mechanism of VA RNA function in the absence of adenovirus infection."
07/01/1998 - "Therefore the minimum set of genes required to produce AAV helper activity equivalent to that provided by adenovirus infection consists of, or is a subset of, the following genes: the E4orf6 gene, the 72-M(r), E2A protein gene, the VA RNA genes and the E1 region. "
12/01/1989 - "These results directly show that the primary function of VAI RNA in the lytic adenovirus infection is the inhibition of eIF-2 alpha phosphorylation by DAI kinase and identify eIF-2 alpha as the target that mediates the effects of DAI kinase activation. "
09/15/1997 - "TDF is selectively inactivated during protein synthesis inhibition by cycloheximide and at a late stage of adenovirus infection, thus accounting for the loss of RNA Pol III-mediated transcription of the tRNA and VA RNA genes under these conditions. "

03/01/2008 - "FK228 improved the efficiency of adenovirus infection. "
02/01/2007 - "These studies suggest that FK228 treatment prior to adenovirus infection could increase the efficiency of adenovirus gene therapy in xenograft model systems."
04/01/2005 - "Recent investigation of a histone deacetylase inhibitor, depsipeptide (FR901228), has demonstrated that it increases cellular susceptibility to adenovirus infection and augments adenoviral transgene expression. "
03/15/2002 - "FR901228 treatment before adenovirus infection was associated with at least a 10-fold increase in transgene expression from a beta-galactosidase-expressing adenoviral vector. "
03/15/2002 - "Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells."

02/20/2015 - "These studies, for the first time, show correlations between cholesterol/lipid rafts, oncolytic adenovirus infection efficiency and the antitumor efficacy of TRAIL at the cellular level. "

01/01/2007 - "This prompted the search for antiviral agents effective against adenovirus infections. "
09/01/2010 - "There is no formally approved treatment of adenovirus infections today, and existing antiviral agents evaluated for their antiadenoviral effect give inconsistent results. "
01/01/1993 - "Antiviral agents for ocular adenovirus infections."
01/01/1993 - "Antiviral agents active against HSV and interferons have been used in the treatment of ocular adenovirus infections with limited effect. "

03/01/1999 - "Upon E2F-1 adenovirus infection, both cell lines expressed elevated levels of E2F-1 protein and then activated a pRb-chloramphenicol acetyltransferase reporter construct containing an E2F-1 binding motif. "
02/05/1992 - "Adenovirus infection of hepatoma cells inhibited transcription of the phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) gene and virtually eliminated transcription of a chimeric gene which contained the PEPCK promoter linked to the structural gene for chloramphenicol acetyltransferase (CAT). "

05/01/2012 - "Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients."
02/01/2011 - "Eradication of disseminated adenovirus infection in a pediatric hematopoietic stem cell transplantation recipient using the novel antiviral agent CMX001."
02/01/2011 - "We report the first case of successful eradication of disseminated adenovirus infection by the novel antiviral agent CMX001 in a severely immunocompromised pediatric stem cell transplant recipient following failure to respond to intravenous cidofovir. "

08/01/2000 - "We report adenovirus infections from an ongoing surveillance study in four patients after a non-myeloablative transplant and their improved outcome following withdrawal of immunosuppression in two patients and donor lymphocyte infusion for relapsed disease in the others. "
11/01/2015 - "All patients were subsequently cleared of adenovirus infection, as evidenced by follow-up biopsies, with no loss of the grafts. "
01/01/2015 - "Brincidofovir, under development by Chimerix, Inc., is being evaluated against adenovirus infections in transplant patients including allo-HSCT patients in a phase III clinical trial (AdVise Study). "
10/01/2005 - "A surveillance study of adenovirus infection in adult solid organ transplant recipients."
07/01/2015 - "Adenovirus infection and disease in paediatric haematopoietic stem cell transplant patients: clues for antiviral pre-emptive treatment."

02/01/2007 - "Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention."
11/01/2010 - "This study provides a rationale and strategy for the adoptive transfer of donor-derived human adenovirus hexon-specific CD8(+) and CD4(+) T cells for the treatment of disseminated adenovirus infection after allogeneic stem cell transplantation."
02/01/2015 - "[A clinical analysis of adenovirus infection after allogeneic stem cell transplantation in 3 patients]."
02/01/2014 - "Patient, virus, and treatment-related risk factors in pediatric adenovirus infection after stem cell transplantation: results of a routine monitoring program."
01/01/2012 - "Adenovirus infection in paediatric allogeneic stem cell transplantation recipients is a major independent factor for significantly increasing the risk of treatment related mortality."

11/01/2010 - "The presence of human adenovirus hexon-specific T cells was investigated in peripheral blood of pediatric and adult allogeneic stem cell transplant recipients, who showed spontaneous resolution of disseminated adenovirus infection. "
12/01/2014 - "The virus is especially threatening for pediatric allogeneic hematopoietic stem cell transplant recipients; according to some studies, 10% or more of these patients succumb to disease resulting from adenovirus infection. "
04/01/2014 - "We present a case series of 2 patients with disseminated adenovirus infection in our centre who presented at different times from the time of transplantation. "
04/01/2014 - "However, disseminated or severe adenovirus infections, including fatal cases, have been described in renal transplant recipients. "
04/01/2014 - "Disseminated adenovirus infection in kidney transplant recipient."

01/01/1985 - "These studies demonstrate that enteric adenovirus infections are major causes of morbidity in hospitalized patients who have of morbidity in hospitalized patients who have undergone ileostomy or colostomy procedures for necrotizing enterocolitis and that the prevention of enteric adenovirus infections might result in a significant improvement in the hospital care of infants with these conditions."
01/01/1985 - "We studied the incidence of enteric adenovirus infections in infants with necrotizing enterocolitis who had undergone intestinal surgery resulting in colostomies or ileostomies. "

01/01/1985 - "These studies demonstrate that enteric adenovirus infections are major causes of morbidity in hospitalized patients who have of morbidity in hospitalized patients who have undergone ileostomy or colostomy procedures for necrotizing enterocolitis and that the prevention of enteric adenovirus infections might result in a significant improvement in the hospital care of infants with these conditions."
01/01/1985 - "We studied the incidence of enteric adenovirus infections in infants with necrotizing enterocolitis who had undergone intestinal surgery resulting in colostomies or ileostomies. "