Adenosine Diphosphate Ribose (ADP-Ribose)

An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.

Also Known As:

ADP-Ribose; ADPribose; Adenosine 5'-Diphosphoribose; 5'-Diphosphoribose, Adenosine; Adenosine 5' Diphosphoribose; Diphosphate Ribose, Adenosine; Diphosphoribose, Adenosine; Ribose, ADP; Ribose, Adenosine Diphosphate; ADP Ribose; Adenosine Diphosphoribose; Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose

Networked: 230 relevant articles (4 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fehr, Anthony R: 5 articles (12/2021 - 02/2015)
2.	Szabó, Csaba: 5 articles (04/2006 - 05/2002)
3.	Johnson, David K: 3 articles (12/2021 - 10/2020)
4.	Ahel, Ivan: 3 articles (10/2021 - 05/2013)
5.	Alhammad, Yousef M O: 3 articles (01/2021 - 01/2020)
6.	Vergote, Ignace: 3 articles (12/2019 - 04/2012)
7.	Beato, Miguel: 3 articles (09/2019 - 06/2016)
8.	Wright, Roni H G: 3 articles (09/2019 - 06/2016)
9.	de Bono, Johann S: 3 articles (09/2016 - 07/2009)
10.	Szabó, Eva: 3 articles (04/2003 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2023 - "PARP-Inhibitoren („Poly-[ADP-Ribose-]Polymerase“) finden Anwendung in der Therapie des metastasierten Prostatakarzinoms, insbesondere Patienten mit einer BRCA-Mutation („BReast CAncer gene“) weisen hohe radiologische Ansprechraten auf, wobei auch zuletzt veröffentlichte Ergebnisse zu Kombinationstherapien von PARP-Inhibitoren mit einer der neuen antihormonellen Substanz diskutiert werden. " 01/30/2023 - "In cancer, overactivation of poly (ADPribose) polymerases (PARP) plays a relevant role in DNA repair. " 01/01/2021 - "In conclusion, our new anti-ADP-ribose antibody revealed heterogeneous ADPR staining patterns with predominant cytoplasmic ADPR staining in most tumor types. " 01/01/2019 - "Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration." 12/01/2018 - "The cancer-related functions of mono(ADP-ribose) generating PARP, including PARP6, remain largely uncharacterized. "
2.	Ovarian Neoplasms (Ovarian Cancer) 09/24/2022 - "Using Patient-Derived Xenograft (PDX) Models as a 'Black Box' to Identify More Applicable Patients for ADP-Ribose Polymerase Inhibitor (PARPi) Treatment in Ovarian Cancer: Searching for Novel Molecular and Clinical Biomarkers and Performing a Prospective Preclinical Trial." 09/01/2022 - "Corrigendum to "correlation of poly (adenosine diphosphate [ADP]-ribose) polymerase expression and prognosis in ovarian cancer: A systematic review and meta-analysis" [J Gynecol Obstet Hum Reprod 2022;51(4): 102344. " 04/01/2022 - "Correlation of poly (adenosine diphosphate[ADP]-ribose) polymerase expression and prognosis in ovarian cancer: A systematic review and meta-analysis." 01/01/2010 - "To estimate the range of poly(adenosine diphosphate [ADP]-ribose) polymerase expression in serous ovarian cancers and to determine whether expression is associated with response to therapy and outcome. " 04/01/2022 - "This meta-analysis evaluated the correlation between poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) expression and prognosis in patients with ovarian cancer. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2023 - "Altered cytoplasmic and nuclear ADP-ribosylation levels analyzed with an improved ADP-ribose binder are a prognostic factor in renal cell carcinoma."
4.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells. " 03/01/2020 - "Recently, various clinical trials have investigated poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor treatment for advanced-stage BRCA1/BRCA2 pathogenic variant breast cancer. " 11/01/2023 - "Talazoparib (TLZ) is a poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor employed for the treatment of breast cancer. " 03/01/2022 - "Management of human epidermal growth factor receptor 2-negative metastatic breast cancer: Role of poly adenosine diphosphate (ADP-ribose) polymerase inhibitors." 05/24/2018 - "Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have shown an impressive safety profile and anti-tumor efficacy in patients with breast cancer 1 and 2 (BRCA1 and BRCA2) gene-mutated ovarian cancer who were previously treated with the standard of care chemotherapy. "
5.	COVID-19 11/13/2020 - "This study provides structural, biophysical, and biochemical bases to further evaluate the role of the SARS-CoV-2 macro domain in the host response via ADP-ribose binding but also as a potential target for drug design against COVID-19." 12/01/2020 - "This study compared their binding sites and suggests the crystal structure of NSP3 of SARS CoV-2 virus as an alternative binding site of AMP or ADP-ribose to treat COVID-19. " 12/01/2020 - "Small molecules that bind the SARS-CoV-2 nonstructural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to the ability of coronaviruses to evade cellular detection. " 09/01/2020 - "Small molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus' ability to evade cellular detection. " 10/15/2022 - "Molecular docking studies are implemented to analyse the binding energy of the BCMTP compound against standard drugs such as the crystal structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES and SARS-CoV-2 main protease with an unliganded active site (2019-nCoV, corona virus disease 2019, COVID-19) and found to be considered having better antiviral agents. "

Related Drugs and Biologics

1.	Adenosine Diphosphate (ADP)
2.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
3.	Polymers
4.	Platinum
5.	niraparib
6.	Alkylating Agents
7.	Proteins (Proteins, Gene)
8.	NAD (NADH)
9.	Enzymes
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Castration
4.	Transplantation
5.	Endarterectomy (Thromboendarterectomy)