HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Adenosine Diphosphate (ADP)

Subscribe to New Research on Adenosine Diphosphate

Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.

Also Known As:

ADP; Pyrophosphate, Adenosine; Adenosine 5'-Pyrophosphate; 5'-Pyrophosphate, Adenosine; ADP, Magnesium; Adenosine 5' Pyrophosphate; Diphosphate, Adenosine; Adenosine Pyrophosphate; Magnesium ADP; MgADP; Adenosine 5'-(trihydrogen diphosphate)

Networked: 3533 relevant articles (95 outcomes, 257 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szabó, Csaba: 17 articles (08/2013 - 09/2002)
2.	Angiolillo, Dominick J: 15 articles (06/2015 - 01/2007)
3.	Heemskerk, Johan W M: 13 articles (03/2015 - 11/2002)
4.	Gurbel, Paul A: 12 articles (12/2013 - 06/2002)
5.	Bürkle, Alexander: 12 articles (07/2013 - 04/2002)
6.	Marcucci, Rossella: 11 articles (09/2015 - 11/2007)
7.	Tantry, Udaya S: 11 articles (12/2013 - 10/2007)
8.	Gori, Anna Maria: 10 articles (09/2015 - 11/2007)
9.	Paniccia, Rita: 10 articles (09/2015 - 11/2007)
10.	Abbate, Rosanna: 10 articles (09/2015 - 11/2007)

Related Diseases

1.	Pulmonary Embolism 08/01/2014 - "siceraria showed a significant increase in tail bleeding time and plasma recalcification time, significant protection against ADP induced pulmonary thromboembolism in mice, and also inhibited the platelet aggregation induced by ADP in vitro. " 06/01/2002 - "PMC was also effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 5 and 10 microg/g. " 10/01/2010 - "The effect to venous thrombosis model and pulmonary thromboembolism model induced by vein injecting ADP and Adr was observed. " 12/01/2011 - "In vivo studies revealed that andrographolide (22 and 55 μg/kg) is effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet plug formation in mice. " 04/01/2001 - "In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. "
2.	Ischemia 01/01/1997 - "After 2 h of ischemia, the penumbra showed a moderate decrease and the focus a marked decrease in ADP-stimulated and uncoupled respiratory rates, with a marked fall in the respiratory control ratio, defined as ADP-stimulated divided by nonstimulated respiration. " 01/01/2010 - "Ischemia reduces the isomerization from A-M.ADP.Pi" 11/20/2006 - "To analyze the cerebrovascular effects of ischemia-reperfusion, cerebrovascular reactivity to ADP was studied after inducing 60-min occlusion followed by 60-min reperfusion of the left middle cerebral artery (MCA) in anesthetized goats. " 11/20/2006 - "Goat cerebrovascular reactivity to ADP after ischemia-reperfusion. " 04/01/2006 - "Meanwhile, the apparent affinity of respiration for ADP (which reflects the matrix volume expansion) is increased during preconditioning stimulus and, to a larger extent, during prolonged ischemia. "
3.	Thrombosis (Thrombus) 05/01/2012 - "We conclude that PKCε negatively regulates ADP-induced thromboxane generation in platelets and offers protection against thrombosis." 01/01/2015 - "Therefore, this study supports a potentially novel autocrine/paracrine role for platelet-derived SDF-1α during thrombosis and haemostasis, through a predominantly TxA2-dependent and ADP-independent pathway." 10/01/2014 - "Clinical studies have identified a strong relationship between diminished platelet-rich thrombus formation, responsiveness to adenosine diphosphate agonism, and severity of TBI. " 03/01/2011 - "Although P2Y12 has a significant role in normal hemostasis and thrombosis, no genetic study has been described about the association between P2Y12 variants and the extent of ADP-induced platelet activation in the Korean population. " 01/01/2003 - "In a previous study, we had shown that freeze-dried extracts of 12-year-old Armagnac could inhibit ADP-induced platelet aggregation in a dose- and duration-dependent manner, and reduce thrombus weight in an experimental rat arteriovenous shunt thrombosis model after 2-week oral treatment. "
4.	Neoplasms (Cancer) 02/01/2006 - "Relative to the first-generation Ad5-CD/TKrep adenovirus, Ad5-yCD/mutTK(SR39)rep-ADP demonstrated greater tumor cell kill in vitro and significantly greater tumor control in preclinical models of human cancer. " 10/10/2002 - "In addition, in combination with a deletion of the ADP, specificity of tumor cell killing is improved." 03/01/2012 - "The pioneering spirit of Takashi Sugimura: his studies of the biochemistry of poly(ADP-ribosylation) and of cancer." 01/01/2012 - "Due to extended number of known MMR cancer causing mutations among the residues proved to make specific contacts with ADP molecules, recommendations for further studies on similar mutagenic effects were made." 04/01/1988 - "These studies indicate that ADP production by these three lines does not arise due to leakage induced by nonspecific membrane damage during cell harvesting and manipulation but is a discrete process under metabolic control of the tumor cells. "
5.	Acute Coronary Syndrome 07/01/2015 - "Medication persistence was assessed among 7,955 MI patients in 216 hospitals participating in the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome study from 2010 to 2012. " 06/01/2015 - "Cluster-randomized clinical trial examining the impact of platelet function testing on practice: the treatment with adenosine diphosphate receptor inhibitors: longitudinal assessment of treatment patterns and events after acute coronary syndrome prospective open label antiplatelet therapy study." 11/01/2011 - "Treatment with adenosine diphosphate receptor inhibitors-longitudinal assessment of treatment patterns and events after acute coronary syndrome (TRANSLATE-ACS) study design: expanding the paradigm of longitudinal observational research." 12/01/2015 - "To validate the EDACS-ADP in a cohort of US ED patients with symptoms suspicious for acute coronary syndrome (ACS). " 12/01/2014 - "Current guideline-based recommendations for oral dual-antiplatelet therapy in an acute coronary syndrome (ACS) include the use of newer adenosine diphosphate receptor inhibitor (ADPri) regimens and agents. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	clopidogrel (Plavix)
3.	Adenosine Monophosphate (AMP)
4.	Collagen
5.	Adenosine Diphosphate (ADP)
6.	Epinephrine (Adrenaline)
7.	Aspirin (Acetylsalicylic Acid)
8.	Arachidonic Acid (Vitamin F)
9.	Ticagrelor
10.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Stents
2.	Intravenous Injections
3.	Transplants (Transplant)
4.	Intranasal Administration
5.	Drug Therapy (Chemotherapy)