Chromophobe Adenoma

07/01/1979 - "Endocrine inactive chromophobe adenomas contain 150 nm granules with no demonstrable hormone function. "
02/20/1974 - "[Proceedings: Hormone secretion in pituitary chromophobe adenoma]."
04/01/1967 - "[Chronic hyperosmolarity with absence of thirst and non-adapted secretion of an anti-diuretic hormone secondary to ablation of a chromophobe adenoma of the pituitary. "
01/01/1981 - "Improved knowledge of histopathology has resulted in the classification being altered : the conventional division into eosinophilic and chromophobe adenomas has been abandoned to be replaced by cellular types corresponding to the various hormone-producing and functional adenomas. "
10/15/1995 - "Eighteen patients had hormone-secreting tumors and three had chromophobe adenomas. "

09/01/1989 - "The results obtained suggest considerable disorders in the dopaminergic regulation of the hypothalamohypophyseal system of patients with chromophobe adenomas and the efficacy of the metoclopramide and Parlodel tests in the differential diagnosis of these conditions."
03/01/1990 - "Functional tests with i.v. injection of metoclopramide (10 mg) and thyroliberin (200 micrograms) with a record of PRL and TSH levels for 120 min. were performed in 87 women of reproductive age (19 healthy nonpregnant women, 9 women in the early postnatal period, 10 patients with primary hypothyroidism, and 30 patients with PRL secreting chromophobe adenomas). "

09/01/1989 - "The results obtained suggest considerable disorders in the dopaminergic regulation of the hypothalamohypophyseal system of patients with chromophobe adenomas and the efficacy of the metoclopramide and Parlodel tests in the differential diagnosis of these conditions."
01/01/1979 - "Glucocorticoids, mineralocorticoids, and adrenal androgens were studied in 3 groups of patients: control subjects (group I), hyperprolactinemic subjects (group II) and miscellaneous patients including chromophobe adenomas and normalized hyperprolactinemic subjects treated with Bromocriptine (group III). "

08/01/1996 - "At surgery, we found a large chromophobe adenoma with few PAS-positive granules and with immunostaining positive for TSH and prolactin. "
01/01/1980 - "In another patient with a chromophobe adenoma of the hypophysis, it reduced the excessively elevated prolactin levels. "
03/01/1977 - "Serum prolactin in patients with "functionless" chromophobe adenomas before and after therapy."
01/01/1977 - "Trans-sphenoidal resection of a prolactin-secreting chromophobe adenoma of the pituitary was carried out 6 months later. "
03/01/1976 - "The fine structure of a prolactin-rich pituitary chromophobe adenoma (a case report)."

04/01/1992 - "Although saccular aneurysms are randomly associated with all types of pituitary tumors, the frequency of this happening with growth hormone-secreting or "chromophobe adenomas" is greater than would be expected by chance alone. "
08/01/1987 - "Both in vivo and in vitro responses of prolactin and growth hormone to stimuli were studied in an acromegalic, amenorrheic woman with a chromophobe adenoma of the pituitary gland. "
06/01/1977 - "Pituitary adenomas obtained from 6 patients with acromegaly and 8 patients with chromophobe adenoma were subjected to the tissue culture to correlate in vitro secretion of growth hormone (GH) and prolactin (PRL) to preoperative in vivo endocrine studies and endocrinilogical manifestations. "
01/01/1981 - "The chromophobe adenoma of anterior lobe consisted of a mixture of non-immunoreactive hormone containing cells and a few prolactin (PRL) and growth hormone (GH) cells in the mid portion whereas the periphery of the tumor contained immunoreactive cells for PRL, GH, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). "

03/01/1995 - "Histopathological examination revealed chromophobe adenoma with proliferation of the collagen fibers. "
04/15/1974 - " In 18 rats remaining from that study autopsies performed 5-20 months after treatment revealed 1) enlarged uteri, 2) increase in collagen, 3) metaplasia of the glands lining the uterine cavity, 4) dilated and cystic glands (uterine), 5) subepithelial neutrophils, 6) mucification of the glandular tissue, 7) inflammatory cells of the subepithelial region, and 8) a similar proportion of control and experimental animals with basophilic or chromophobe adenomas of the pituitary. "

04/01/1987 - "In order to study the light microscopical alterations of pituitary tumours under dopamine agonist treatment, three groups of a total of 18 large or small cell chromophobe adenomas were analysed by light microscopical, immunohistological and morphometrical methods. "

01/01/2006 - "She underwent transsphenoidal surgery, and was diagnosed as chromophobe adenoma with positive ACTH immunoreactivity. "
01/01/1984 - "The light microscopical, electron microscopical and immunohistological features of a rare ACTH-producing chromophobe adenoma of the pituitary gland in an 11-month-old infant are presented. "
09/01/1974 - "[Proceedings: Anomalies in the regulation of the secretion of corticotropin in chromophobe adenomas]."
03/01/1980 - "36 pituitary tumours have been explanted to in vitro culture: 20 tumours causing acromegaly, 9 porlactinomas, 2 ACTH-producing and 5 chromophobe adenomas. "
11/01/1979 - "Acute and prolonged alpha 1-24 corticotropin stimulation was performed on a treated chromophobe adenoma patient with partial ACTH deficiency and extreme hyperprolactinemia. "

07/01/1977 - "The secretion and biological activity of thyroid stimulating hormone (TSH) were studied in 22 patients with a pituitary tumour (17 acromegalics and 5 patients with a chromophobe adenoma) and in 36 hypophysectomized patients (16 acromegalics and 20 with a chromophobe adenoma). "
11/12/1970 - "Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma."
08/01/1982 - "Hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor."
03/01/1977 - "The immunoreactive serum human prolactin (PRL) level was measured before and after intravenous administration of 500 mug of thyrotrophin-releasing hormone (TRH) in 11 patients with "functionless" chromophobe adenomas before and after surgery and after radiotherapy in 6 of these patients. "
01/01/1981 - "The chromophobe adenoma of anterior lobe consisted of a mixture of non-immunoreactive hormone containing cells and a few prolactin (PRL) and growth hormone (GH) cells in the mid portion whereas the periphery of the tumor contained immunoreactive cells for PRL, GH, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). "

12/01/1977 - "LHbeta subunit was present in the culture medium of the pituitary fragments from the castrated man and from the women with Nelson's syndrome and Forbes Albright syndrome but not in that of the woman with chromophobe adenoma. "
12/01/1977 - "Fragments from 4 human pituitaries removed at surgery from one gonadectomized man and three women (one with Nelson's syndrome, one with Forbes Albright syndrome and one with chromophobe adenoma) were grown in tissue culture. "
10/01/1958 - "[Chromophobe adenoma of pituitary gland with amonrrhea-galactorrhea syndrome (Forbes-Albright syndrome or d'Argonz-Del Castillo syndrome)]."
07/01/1958 - "[Amenorrhea-galactorrhea syndrome associated with pituitary chromophobe adenoma (the Argonz-del Castillo or Forbes-Albright syndrome)]."

10/01/1979 - "A patient had radiation necrosis of the brain after treatment for a chromophobe adenoma of the pituitary. "
03/01/1977 - "These results indicate: (1) that measurement of serum PRL levels at basal and after TRH administration in patients with "functionless" chromophobe adenomas before and after treatment may be the best index for evaluating the effect of therapy; (2) that adenoma removal may be followed by preservation of normal pituitary function, but this is more likely to occur if the transsphenoidal approach is used; and (3) that primary thyroid insufficiency may be associated with a pituitary adenoma."
10/20/1975 - "Unilateral exophthalmos developed shortly after treatment in three patients with chromophobe adenoma of the pituitary gland and craniopharyngioma. "
04/15/1974 - " In 18 rats remaining from that study autopsies performed 5-20 months after treatment revealed 1) enlarged uteri, 2) increase in collagen, 3) metaplasia of the glands lining the uterine cavity, 4) dilated and cystic glands (uterine), 5) subepithelial neutrophils, 6) mucification of the glandular tissue, 7) inflammatory cells of the subepithelial region, and 8) a similar proportion of control and experimental animals with basophilic or chromophobe adenomas of the pituitary. "

03/01/1989 - "This is thought to be a rare complication of post-radiation to a chromophobe adenoma which was treated by radiotherapy nine years previously. "
04/16/1988 - "In a case of chromophobe adenoma operated twice at 1 year interval, radiotherapy (4,500 rads) after the second operation resulted in complete cure confirmed by computerized tomography 15 years later. "
02/01/1985 - "Transfrontal resection of a chromophobe adenoma followed by radiotherapy, performed both at this time and again after a recurrence eight years later, failed to eradicate the tumour. "
02/01/1968 - "[Radiotherapy of chromophobe adenomas]."
12/01/1967 - "The radiotherapy of pituitary chromophobe adenomas: an evaluation of indication, technic, and result."

06/01/1983 - "The patient had transsphenoidal hypophysectomy for chromophobe adenoma, complicated by rhinorrhea, which was corrected by subarachnoid drainage. "
07/01/1977 - "Hypophysectomy caused an immediate but transient decrease in peak TSH in patients with a chromophobe adenoma only. "
10/01/1992 - "A 48-year-old man had a trans-sphenoidal hypophysectomy and transcranial partial removal of a recurrent pituitary chromophobe adenoma followed by a course of radiotherapy in 1980. "
10/01/1976 - "The patient's hypercortisolism disappeared following removal of the chromophobe adenoma through transphenoidal hypophysectomy."
07/01/1978 - "In the same groups of three normal and three GH-deficient subjects, 5 mg hGH administered iv induced an elevation of NSILA-S within 15-60 min. Hypophysectomy in three acromegalics and one subject with a chromophobe adenoma was followed by significant falls of serum NSILA-S. "

01/01/1985 - "A chromophobe adenoma was partially removed by right frontal craniotomy. "
06/01/1982 - "[Case of Cushing's disease with pituitary chromophobe adenoma probably triggered by cerebral angiography and craniotomy]."
01/01/1987 - "Under the diagnosis of a non-functioning pituitary adenoma with supra-sellar extension, a craniotomy was done and intracapsular partial removal of the tumor was made, revealing a chromophobe adenoma in light microscopy and undifferentiated cell adenoma in electron-micrographs.(ABSTRACT TRUNCATED AT 250 WORDS)"

08/01/2003 - "Necrosis within a chromophobe adenoma was found upon surgical decompression of the sella. "
08/01/1990 - "Necrosis within a chromophobe adenoma was found at surgical decompression of the sella."