Basophil Adenoma

A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)

Also Known As:

Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Pituitary ACTH Hypersecretion
3.	Hyperplasia
4.	Bipolar Disorder (Mania)
5.	Anorexia Nervosa

Experts

1.	Betz, Laura J: 1 article (04/2007)
2.	Seely, John Curtis: 1 article (04/2007)
3.	Hard, Gordon C: 1 article (04/2007)
4.	Hayashi, Shim-Mo: 1 article (04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Basophil Adenoma:

1.	Cyproheptadine (Periactin)FDA Link 12/01/1982 - "Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma." 12/01/1982 - "We report the successful use of cyproheptadine in a 54-year-old man with Cushing's disease due to pituitary basophil adenoma. "
2.	Adrenocorticotropic Hormone (ACTH)FDA Link 12/01/1983 - "A case is described of recurrent mania without depressive episodes in a patient subsequently diagnosed as having an ACTH-producing basophil adenoma. " 12/01/1986 - "It is suggested that increased hypothalamic-pituitary corticotroph stimulation in association with the anorexia nervosa, a now well-established endocrine phenomenon, activated an occult, inactive pituitary basophil adenoma in this patient, eventually resulting in autonomous pituitary overproduction of ACTH by the tumor." 01/01/1978 - "In one case of pituitary basophil adenoma, the majority of the cells contains numerous small granulations which, by using immunohistoenzymatic technique, react with alpha, 17-39 ACTH and beta, MSH antisera. " 01/01/1979 - "ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. "
3.	Hematoxylin (Haematoxylon)IBA 01/01/1977 - "Basophilic adenomas, composed of melanocorticotroph cells and associated with Cushing's disease or with Nelson's syndrome or unaccompanied by hormonal hypersecretion, showed intense lead hematoxylin positivity. " 06/01/1993 - "On routine hematoxylin and eosin (H&E) staining, there were thirty-three chromophobe, seven eosinophilic, and one basophilic adenoma. " 03/01/1980 - "These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. "
4.	beta-MSHIBA 01/01/1978 - "In one case of pituitary basophil adenoma, the majority of the cells contains numerous small granulations which, by using immunohistoenzymatic technique, react with alpha, 17-39 ACTH and beta, MSH antisera. " 01/01/1979 - "ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. "
5.	Periodic AcidIBA 01/01/1985 - "These tumors were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) positivity and chromophobic adenomas with moderate or no PAS positivity. " 03/01/1980 - "These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. "
6.	QuercetinIBA 04/01/2007 - "The evidence linked the occurrence of the predominant basophilic adenomas and foci of atypical tubule hyperplasia (ATH) with the exacerbation of CPN to advanced grades of severity, supporting a mode of action involving quercetin interaction with CPN. "
7.	beta-Lipotropin (Lipotropin)IBA 01/01/1979 - "ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. "
8.	Leucine (L-Leucine)FDA Link 01/01/1979 - "ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. "
9.	Immune Sera (Antisera)IBA 01/01/1978 - "In one case of pituitary basophil adenoma, the majority of the cells contains numerous small granulations which, by using immunohistoenzymatic technique, react with alpha, 17-39 ACTH and beta, MSH antisera. "
10.	HormonesIBA 01/01/1979 - "The reason why these hormones are clinically silent in "chromophobe" or, even, basophilic adenomas is still to be elucidated."

Therapies and Procedures

1.	Hypophysectomy 04/06/1978 - "In one patient total hypophysectomy revealed a 1.5-mm basophilic adenoma, and in two patients vascular anomalies prevented sellar exploration. "
2.	Adrenalectomy 01/01/1955 - "[Metastasizing, predominantly basophilic adenoma of the anterior pituitary with recurrent Cushing disease after subtotal adrenalectomy]."