Papillary Adenocarcinoma

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

Also Known As:

Networked: 255 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Adenocarcinoma
4.	Ovarian Neoplasms (Ovarian Cancer)
5.	Clear Cell Adenocarcinoma

Experts

1.	Casagrande, F: 2 articles (09/2010 - 01/2010)
2.	Buza, N: 2 articles (09/2010 - 01/2010)
3.	Rutherford, T J: 2 articles (09/2010 - 01/2010)
4.	Silasi, D-A: 2 articles (09/2010 - 01/2010)
5.	Santin, A D: 2 articles (09/2010 - 01/2010)
6.	Azodi, M: 2 articles (09/2010 - 01/2010)
7.	Bellone, M: 2 articles (09/2010 - 01/2010)
8.	Schwartz, P E: 2 articles (09/2010 - 01/2010)
9.	Pecorelli, S: 2 articles (09/2010 - 01/2010)
10.	Cocco, E: 2 articles (09/2010 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Papillary Adenocarcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 04/01/2004 - "We studied the roles of FKHRL1 in both cisplatin-resistant Caov-3 (a papillary adenocarcinoma cell line) and cisplatin-sensitive A2780 human ovarian cancer cell lines. " 11/01/2005 - "Villoglandular papillary adenocarcinoma of the uterine cervix responding to neoadjuvant chemotherapy with docetaxel and cisplatin: a case report." 06/01/2001 - "[A case of papillary adenocarcinoma of the ovary that responded favorably to irinotecan hydrochloride and cisplatin after the administration of paclitaxel and carboplatin]." 02/01/1993 - "A new epithelial ovarian carcinoma cell line (UCI 101) has been established from the ascitic fluids and solid tumor of a patient with progressive papillary adenocarcinoma of the ovary shown previously to be refractory to combination chemotherapy consisting of cyclophosphamide, Adriamycin, and cisplatin as well as single-agent chemotherapy of taxol and high-dose cisplatin. "
2.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2005 - "A 63-year-old woman received chemotherapy combining carboplatin and paclitaxel for recurrent ovarian serous papillary adenocarcinoma. " 06/01/2001 - "[A case of papillary adenocarcinoma of the ovary that responded favorably to irinotecan hydrochloride and cisplatin after the administration of paclitaxel and carboplatin]." 02/01/1993 - "A new epithelial ovarian carcinoma cell line (UCI 101) has been established from the ascitic fluids and solid tumor of a patient with progressive papillary adenocarcinoma of the ovary shown previously to be refractory to combination chemotherapy consisting of cyclophosphamide, Adriamycin, and cisplatin as well as single-agent chemotherapy of taxol and high-dose cisplatin. "
3.	Carboplatin (JM8)FDA LinkGeneric 01/01/2005 - "A 63-year-old woman received chemotherapy combining carboplatin and paclitaxel for recurrent ovarian serous papillary adenocarcinoma. " 06/01/2001 - "[A case of papillary adenocarcinoma of the ovary that responded favorably to irinotecan hydrochloride and cisplatin after the administration of paclitaxel and carboplatin]."
4.	irinotecan (Camptosar)FDA LinkGeneric 06/01/2001 - "[A case of papillary adenocarcinoma of the ovary that responded favorably to irinotecan hydrochloride and cisplatin after the administration of paclitaxel and carboplatin]."
5.	Estrogens (Estrogen)FDA Link 06/01/2014 - "Based at shis study it may be concluded thate the use of immunohistochemical studies particularly a detection of negative estrogen and progesterone resceptor phenotype and high expression of the proliferation marker Ki-67 is an additional defferential diagnostic eriterion for the diagnosis of serous papillary adenocarcinoma of the uterine body thet will ensure adepuate therapeutis approach to patients suffering from this disorder. " 01/01/1993 - "Epidemiological evidence suggests that gonadotropins and estrogens may be important in the development of OV Ca. We have established permanent cultures of OV Ca cells from a mesenteric metastasis of an ovarian papillary adenocarcinoma. " 11/01/1992 - "Estrogen or progesterone receptors or both were identified in 6 of 9 tubular adenocarcinomas, 4 of 5 papillary adenocarcinomas, and 1 of 1 squamous cell carcinoma. " 04/01/1990 - "Primary and metastatic tumor tissues of serous papillary adenocarcinoma of the endometrium were examined for the following: (1) amplification of int-2, c-erbB-2 and c-myc proto-oncogenes by Southern blot hybridization; (2) DNA ploidy by flow cytometric study; (3) and expression of specific proteins, such as estrogen and progesterone receptors, keratin, vimentin, and carcinoembryonic antigen (CEA) using immunohistochemical and biochemical techniques. "
6.	MucinsIBA 11/01/2012 - "The histopathological diagnosis was mucin-producing papillary adenocarcinoma(T1N0M0, Stage I) of the gallbladder." 11/01/2012 - "[A case in which a mucin-producing papillary adenocarcinoma of the gallbladder was resected]." 06/01/2005 - "We present a unique case of a mucin-secreting papillary adenocarcinoma of intestinal type which has invaded and completely destroyed the hyoid bone and metastasized to the cervical lymph nodes bilaterally. " 06/01/2005 - "Mucin-secreting papillary adenocarcinoma of the hyoid bone: a unique case." 05/01/2005 - "We reported this case because it was a rare slow-growing papillary adenocarcinoma that did not produce mucin and had a 19-year clinical history before operation."
7.	Keratins (Keratin)IBA 01/01/2005 - "Immunostaining of the tumor cells was positive for cytokeratin (CK) of wide-spectrum screening and for CK 7. The diagnosis of papillary adenocarcinoma of the extrahepatic bile duct was based on the morphologic features of the neoplasm and evidence of local invasion. " 01/01/1995 - "Basal cells were positive for high molecular weight cytokeratin in 2 cases of papillary hyperplasia but were missing in papillary adenocarcinoma. " 10/01/1992 - "Immunohistochemical staining revealed that elements of the papillary adenocarcinoma were positive for carcinoembryonic antigen, epithelial membrane antigen, keratin, endocrine granule constituent, and CA19-9, while components of the small cell carcinoma were weakly positive only for neuron-specific enolase. " 01/01/2001 - "To elucidate the characteristics of NOCS arising from ovarian carcinoma, we investigated the immunohistochemical reactivities of keratin, epithelial membrane antigen(EMA), vimentin, and proliferative cell nuclear antigen(PCNA) in 4 cases of ovarian carcinoma with NOCS(NOCS group), including 3 cases of serous surface papillary adenocarcinoma(SSPC) and 1 case of small ovarian primary serous papillary adenocarcinoma(SPC). " 04/01/1990 - "Primary and metastatic tumor tissues of serous papillary adenocarcinoma of the endometrium were examined for the following: (1) amplification of int-2, c-erbB-2 and c-myc proto-oncogenes by Southern blot hybridization; (2) DNA ploidy by flow cytometric study; (3) and expression of specific proteins, such as estrogen and progesterone receptors, keratin, vimentin, and carcinoembryonic antigen (CEA) using immunohistochemical and biochemical techniques. "
8.	Carcinoembryonic AntigenIBA 02/01/2005 - "Papillary adenocarcinoma of the renal pelvis and ureter producing carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125." 12/01/2002 - "Papillary adenocarcinoma of the ureter producing carcinoembryonic antigen and carbohydrate antigen 19-9." 01/01/2000 - "Immunohistochemically, tumor cells of the papillary adenocarcinoma component were positive for carcinoembryonic antigen, secretory component, and lactoferrin. " 10/01/1992 - "Immunohistochemical staining revealed that elements of the papillary adenocarcinoma were positive for carcinoembryonic antigen, epithelial membrane antigen, keratin, endocrine granule constituent, and CA19-9, while components of the small cell carcinoma were weakly positive only for neuron-specific enolase. " 03/01/2002 - "To evaluate the role of mesothelial markers (calretinin, thrombomodulin, cytokeratin 5/6, and CD44H) and carcinoma markers (polyclonal and monoclonal carcinoembryonic antigen, Leu-M1, CA-125 and Ber-EP4) in distinguishing diffuse peritoneal malignant mesothelioma from primary serous papillary adenocarcinoma of the ovary and peritoneum. "
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/1995 - "[Examination by image analysis for determining quantitative DNA parameters of serous papillary adenocarcinoma of the endometrium--a single case analysis]." 01/01/1992 - "There was no difference in clinical findings or nuclear DNA content (NDC) between the BAC and papillary adenocarcinoma with thin fibrovascular stroma. " 01/01/1995 - "These results and the slight variability of DNA-pattern at the reported serous-papillary adenocarcinoma support the hypothesis of an own entity of this tumor. " 10/01/1994 - "Loss of heterozygosity (LOH) on chromosome 16q was examined in DNA isolated from 11 intraductal papillomas and 12 intracystic papillary adenocarcinomas of the breast. " 11/01/1982 - "We studied the relationship between Ga-67 uptake and nuclear DNA content in four papillary adenocarcinomas, three follicular adenocarcinomas, three anaplastic carcinomas, and five malignant lymphomas of the thyroid gland. "
10.	VimentinIBA 11/01/2009 - "Papillary adenocarcinomas were consistently vimentin negative. " 01/01/2001 - "To elucidate the characteristics of NOCS arising from ovarian carcinoma, we investigated the immunohistochemical reactivities of keratin, epithelial membrane antigen(EMA), vimentin, and proliferative cell nuclear antigen(PCNA) in 4 cases of ovarian carcinoma with NOCS(NOCS group), including 3 cases of serous surface papillary adenocarcinoma(SSPC) and 1 case of small ovarian primary serous papillary adenocarcinoma(SPC). " 04/01/1990 - "Primary and metastatic tumor tissues of serous papillary adenocarcinoma of the endometrium were examined for the following: (1) amplification of int-2, c-erbB-2 and c-myc proto-oncogenes by Southern blot hybridization; (2) DNA ploidy by flow cytometric study; (3) and expression of specific proteins, such as estrogen and progesterone receptors, keratin, vimentin, and carcinoembryonic antigen (CEA) using immunohistochemical and biochemical techniques. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2013 - "Again after latent period of 10 months patient had papillary adenocarcinoma of ovary for which she was administered chemotherapy. " 03/01/2011 - "Thus, high rates of KEAP1 mutations and NRF2 overexpression in true papillary adenocarcinoma could be related to poor prognosis and chemotherapy resistance. " 08/01/2010 - "We sought to identify effective chemotherapy regimens against uterine serous papillary adenocarcinoma (USPC). " 10/01/2007 - "After four cycles of chemotherapy a localized, grade 3 serous papillary adenocarcinoma was resected followed by further chemotherapy and radiation. " 09/01/2001 - "Serous papillary adenocarcinomas of the ovary display heterogeneity in their response to chemotherapy."
2.	Thyroidectomy 11/01/2014 - "Cytological examination of fine needle aspirates revealed 1 case to be Class II and 3 cases to be Class III. The diagnosis, which was made during the operation procedure on the basis of the frozen section and final operative methods, was papillary adenocarcinoma in 2 cases (total thyroidectomy + D1 and subtotal thyroidectomy+D1) and suspected papillary adenocarcinoma in 2 cases (hemithyroidectomy+ D1 and lobectomy of the thyroid+D1). " 12/01/2001 - "The patient was subsequently diagnosed as having thyroid papillary adenocarcinoma and received a subtotal thyroidectomy. " 07/01/1988 - "Three years later, a struma was found and subtotal thyroidectomy revealed a papillary adenocarcinoma." 07/01/2013 - "The incisional biopsy on mediastinoscopy revealed a papillary adenocarcinoma of thyroid and a total thyroidectomy with resection of mediastinal lymph node through cervical and reverse-T upper mini-sternotomy approach was performed. " 03/01/2000 - "Total thyroidectomy was performed, and histologic examination of the removed thyroid tissue confirmed the diagnosis of Graves' disease and also the presence of sarcoid granuloma and metastatic papillary adenocarcinoma with spread to neck lymph nodes. "
3.	Pancreaticoduodenectomy 01/01/2014 - "A 79-year-old woman underwent pancreatoduodenectomy for a 22 mm microinvasive papillary adenocarcinoma of the ampulla. " 03/01/2001 - "We performed pancreatoduodenectomy, and examination of the resected specimen showed well-differentiated papillary adenocarcinoma. " 04/01/1985 - "We describe a new case of ductal papillary adenocarcinoma of the pancreas, resected in 1976 (cephalic pancreatoduodenectomy). " 11/01/2001 - "Papillary adenocarcinoma is associated with good prognosis since it is totally removed by radical resection, and pancreaticoduodenectomy can be performed successfully during pregnancy, but the patient must receive special prenatal care." 09/01/2007 - "Pancreaticoduodenectomy was performed in 1980 and histological examination of original tumor revealed a stage IIA papillary adenocarcinoma (pT3, pN0, pM0). "
4.	Radiotherapy 03/01/1992 - "[Papillary adenocarcinoma of the prostate with good response to antiandrogen therapy and delayed radiotherapy: a case report]." 08/01/2013 - "Diffusely metastatic digital papillary adenocarcinoma 11 years after initial presentation treated with palliative chemotherapy and radiotherapy." 01/01/1980 - "Second fatal mesenchymal and epithelial primaries have been described in 8.5% of patients with bilateral retinoblastomas previously treated with radiotherapy; however, papillary adenocarcinoma arising within the paranasal sinuses has not been reported. " 01/01/1980 - "An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. " 01/01/1985 - "Papillary neoplasms were morphologically subclassified as either papillary serous adenocarcinoma or well-differentiated papillary adenocarcinoma, following review of the histological sections obtained prior to radiotherapy or chemotherapy. "
5.	Ovariectomy (Oophorectomy) 01/01/2002 - "[Serous-papillary adenocarcinoma with Müllerian neoplasia after prophylactic ovariectomy]." 06/01/1989 - "Pathological examination of the upper vaginectomy and bilateral salpingo-oophorectomy specimen revealed a primary papillary adenocarcinoma of the left fallopian tube that had invaded directly into the mucosa of the vaginal apex. " 11/01/2011 - "A patient with stage IIIC serous papillary adenocarcinoma underwent hysterectomy with bilateral salpingo-oophorectomy. " 05/01/1982 - "A 64-year-old patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy in October, 1978 for a Stage IA, grade 2 papillary adenocarcinoma of the endometrium. "