Adenine Phosphoribosyltransferase

06/01/2004 - "Lesch-Nyhan syndrome is a disorder caused by congenital absence of the enzyme hypoxanthineguanine phosphoribosyltransferase and an increase of the enzyme activity of adenine phosphoribosyltransferase. "
11/01/1973 - "Erythrocyte adenine phosphoribosyltransferase in the Lesch-Nyhan syndrome."
01/01/1978 - "Effect of blood transfusion on activities of hypoxanthineguanine phosphoribosyltransferase (E.C.2.4.2.8.) and adenine phosphoribosyltransferase (E.C.2.4.2.7.) in cirulating red blood cells of a patient with Lesch-Nyhan syndrome."
11/01/1998 - "Carrier testing was performed in 35 women belonging to 16 unrelated Spanish families with at least one subject affected by the Lesch-Nyhan syndrome (11 families, 14 patients) or the Kelley-Seegmiller syndrome (five families, six patients) by means of HPRT and adenine phosphoribosyltransferase activities in hair follicles and/or molecular studies. "
06/01/1980 - "Prenatal diagnosis of Lesch-Nyhan syndrome and some characteristics of hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase in human tissues and cultivated cells."

01/01/1994 - "This is an infrequent but potentially serious form of lithiasis, of purinic origin, caused by a genetic abnormality (deficit of adenine phosphoribosyltransferase, APRT) affecting both sexes. "
09/01/1974 - "[A new metabolic disease: the complete deficit of adenine phosphoribosyltransferase and lithiasis of 2,8-dihydroxyadenine]."
01/01/2000 - "In this study, we found 2,8-dihydroxyadenine (DHA) lithiasis in Japanese patients who were heterozygous for Japanese-type (type II) adenine phosphoribosyltransferase (APRT) deficiency (APRT*J). "
10/19/2002 - "[Uncommon purine lithiasis: adenine phosphoribosyltransferase (APRT) deficiency and hereditary xanthinuria]."
05/01/1991 - "All reported cases of 2,8-dihydroxyadenine (DHA) lithiasis have been due to functional homozygous deficiency of adenine phosphoribosyltransferase (APRT). "

03/01/1972 - "Adenine phosphoribosyltransferase activities of mouse ascites tumors and derived tumorigenic and nontumorigenic tissue culyures."
04/01/1967 - "Studies on the nature of the regulation by purine nucleotides of adenine phosphoribosyltransferase and of hypoxanthine phosphoribosyltransferase from Ehrlich ascites-tumour cells."
09/01/1966 - "2. The reaction of 5'-phosphoribosyl pyrophosphate with adenine phosphoribosyltransferase from ascites-tumour cells (K(m) 6.5-11.9mum) was competitively inhibited by AMP, ADP, ATP and GMP (K(i) 7.5, 21.9, 395 and 118mum respectively). "

06/22/2004 - "Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis."
10/01/1998 - "[2,8-dihydroxyadenine urolithiasis due to partial deficiency of adenine phosphoribosyltransferase: a case report]."
01/01/1981 - "Dihydroxyadenine urolithiasis in children with partial deficiency of adenine phosphoribosyltransferase."
06/07/1980 - "Complete lack of adenine phosphoribosyltransferase (APRT) is a not uncommon cause of urinary lithiasis in young children. "
06/07/1980 - "[Hereditary deficiency in adenine phosphoribosyltransferase: a metabolic cause of urinary lithiasis in children (author's transl)]."

11/19/1986 - "Adenine phosphoribosyltransferase has been purified to apparent homogeneity from mouse mammary tumor FM3A cells. "
06/01/1991 - "We analyzed the nature of spontaneous mutations at the autosomal locus coding for adenine phosphoribosyltransferase in the human colorectal carcinoma cell line SW620 to establish whether distinctive mutational pathways exist that might underlie the more complex genome rearrangements arising in tumor cells. "
03/01/1972 - "Adenine phosphoribosyltransferase activities of mouse ascites tumors and derived tumorigenic and nontumorigenic tissue culyures."
06/01/2011 - "Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. "
12/01/2006 - "The involvement of the purine salvage pathway in tumor proliferation and angiogenesis makes adenine phosphoribosyltransferase a potential target for oncology drug discovery. "