Adenine Nucleotides

07/01/2006 - "The adenosine phosphates levels of ischemia/reperfusion group were significantly lower than those of the control group (P<0.01). "
07/01/2002 - "These effects are proposed to lead to preservation of adenine nucleotides during ischemia and efficient energy transfer upon reperfusion."
12/01/2001 - "Adenine nucleotides of the myocardium were better preserved in Group B than in other two groups 30 min, 60 min after ischemia, and 20 min after reperfusion (P < 0.05 and 0.01, respectively). "
09/01/2000 - "The analysis of adenine nucleotides during AF provided no indication for the development of severe atrial ischemia. "
11/01/1996 - "Suppression of the degradation of adenine nucleotides during ischemia may not be a sufficient mechanism for infarct size limitation by preconditioning."

01/01/2013 - "To determine the influence of ischemia-reperfusion injury on ectonucleotidase activity in coronary vascular bed, we compared the metabolic profile of adenine nucleotides during the coronary circulation in pre- and post-ischemic heart. "
07/01/1994 - "Increased degradation of myocardial adenine nucleotides and concomitant lipid peroxidation may play a specific role in the development of reperfusion injury. "
07/01/2005 - "The renal interstitial concentrations of adenosine and adenine nucleotides in response to ischemia-reperfusion injury, either following 1-3 cycles of IPC or not, were measured simultaneously using microdialysis sampling technology. "
07/01/2005 - "To investigate the effects of renal ischemic preconditioning (IPC) on both renal hemodynamics and the renal interstitial concentrations of adenosine and adenine nucleotides induced by ischemia-reperfusion injury. "
02/01/1993 - "We conclude that superoxide radicals inhibit the catabolism of extracellular adenine nucleotides by the ectonucleotidases of endothelial cells and may thus modify the pathophysiology of ischemia-reperfusion injury."

01/01/2008 - "This study was designed to establish the extent of anoxia-induced depletion of non-adenine nucleotides in the cytosolic compartment of heart muscle cells. "
04/01/2002 - "Catabolism of cytoplasmic and intramitochondrial adenine nucleotides in C2C12 skeletal myotube under chemical hypoxia."
10/15/2001 - "Neither arterial nor venous nor interstitial concentrations of adenine nucleotides changed significantly in hypoxia. "
08/15/1994 - "The influence of hypoxia and anoxia on distribution of adenine nucleotides in isolated hepatocytes."
04/01/1991 - "In ventilated lungs, inspired PO2 of 200 (normoxia), 50 (hypoxia), and 0 Torr (anoxia) did not change adenine nucleotides but resulted in steady-state pulmonary arterial pressure (Ppa) values of 15.5 +/- 1.4, 30.3 +/- 1.8, and 17.2 +/- 1.9 mmHg, respectively, indicating vasoconstriction during hypoxia and reversal of vasoconstriction during anoxia. "

02/01/1990 - "The purpose of the present study was to determine if repetitive myocardial ischemia would result in the cumulative loss of mitochondrial adenine nucleotides. "
12/01/1991 - "Mechanism of loss of adenine nucleotides from mitochondria during myocardial ischemia."
10/01/1987 - "Thus, nicorandil improved both function and metabolism during recurrent myocardial ischemia independent of a hemodynamic effect, whereas ISDN only attenuated the loss of adenine nucleotides and increase in tissue water."
01/14/2011 - "Enzymes that hydrolyze adenine nucleotides in patients with ischemic heart disease."
12/01/1992 - "One of the early metabolic changes associated with myocardial ischemia is the breakdown of adenine nucleotides resulting in the enhanced production of adenosine. "

01/01/1976 - "Both cases were associated with a bleeding diathesis, a defect of platelet aggregation, and a deficiency of platelet adenine nucleotides. "
01/01/1976 - "The demonstration that small doses of serotonin were effective in reversing the bleeding tendency in beige mice suggested a causal role for defective storage and release of endogenous serotonin as the basis for the bleeding tendency, acting either independently or synergistically with impaired release of adenine nucleotides."
08/27/1994 - "The 40%--and, to a lesser extent, 20%--livers had higher and more uniformly distributed portal blood flow, better tissue oxygenation, smaller increases in postperfusion liver enzymes, higher adenine nucleotides and energy charge, and less histopathologic evidence of hemorrhage and congestion. "
12/01/2000 - "AICAR attenuated gut permeability changes, increased mucosal perfusion, and increased tissue adenine nucleotides, which is consistent with preserved intestinal barrier function after hemorrhage and fluid resuscitation. "
01/01/1982 - "The Hermansky-Pudlak syndrome is a mild bleeding disorder in which the platelets are markedly deficient in the storage pool of adenine nucleotides and serotonin. "