Acute-Phase Proteins (Acute-Phase Protein)

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

Also Known As:

Networked: 3177 relevant articles (47 outcomes, 308 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eckersall, P D: 16 articles (11/2014 - 01/2001)
2.	Herndon, David N: 13 articles (03/2015 - 04/2003)
3.	Heegaard, Peter M H: 10 articles (08/2015 - 03/2009)
4.	Rudd, Pauline M: 8 articles (03/2015 - 12/2007)
5.	Cerón, J J: 8 articles (04/2013 - 02/2002)
6.	Jeschke, Marc G: 7 articles (03/2015 - 06/2004)
7.	Ceciliani, Fabrizio: 7 articles (04/2013 - 06/2002)
8.	Koenig, Wolfgang: 7 articles (08/2009 - 11/2002)
9.	Sobieska, Magdalena: 7 articles (01/2008 - 01/2006)
10.	Jacobsen, Stine: 6 articles (01/2016 - 03/2009)

Related Diseases

1.	Inflammation 01/01/1996 - "The LAA test is superior to other acute phase reactants used in daily practice to detect the presence of inflammation as well as for the assessment of its severity in adolescent patients with IBD. " 01/01/2002 - "In addition, markers of inflammation and acute-phase reactants were measured in order to compare activity during active disease and during remission. " 05/01/2015 - "The objective of this study was to compare serum acute phase proteins of racehorses with and without lower airway inflammation. " 11/01/2014 - "The absence of LPS in peripheral blood and the lack of increase in acute phase proteins indicated that the grain feeding protocol used in the current study and the accompanying changes in LPS concentrations of the digesta did not result in systemic inflammation. " 11/01/2013 - "A number of studies have shown that MetS is associated with a state of low-grade inflammation, characterized by abnormal pro-inflammatory cytokine production, increased acute-phase reactants, and activation of a network of inflammatory signalling pathways. "
2.	Arthritis (Polyarthritis) 11/01/1980 - "Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. " 03/01/2007 - "Traditionally, clinical trials for inflammatory arthritis have used composite response indices such as American College of Rheumatology response or improvement in Disease Activity Score as outcomes based on multiple joint clinical measures, acute phase reactants, and functional status. " 03/01/2005 - "MRA abruptly reduced disease activity in 10 of the 11 children, as assessed by the occurrence of febrile episodes, active arthritis, scores on the Childhood Health Assessment Questionnaire, and levels of acute-phase reactants. " 03/01/2015 - "The FMF50 score required improvement by ≥ 50 in five of six criteria (attack frequency, attack duration, global patient assessment, global physician assessment, frequency of attacks with arthritis, and levels of acute-phase reactants) without worsening of the sixth criterion. " 11/01/2014 - "Patients with K kingae arthritis usually presented with mildly abnormal clinical picture and normal serum levels of or near-normal acute-phase reactants. "
3.	Infection 06/01/2014 - "The objective of this study was to measure plasma protein fractions by electrophoresis to determine if an acute-phase protein response occurs in RES during infection with a frog virus 3-like ranavirus (FV3-like virus) isolated from a chelonian. " 09/28/2011 - "In the present study, acute phase proteins (APP) responses in pigs after infection with toxigenic strain of Pasteurella multocida (Pm) were evaluated. " 01/01/2001 - "Several recent studies have elevated the role of acute phase proteins (APPs) as predictive markers in infection. " 06/01/1999 - "Although several studies have shown that asymptomatic human immunodeficiency virus infection elicits an increase in whole body protein turnover, it is not known whether this increased protein turnover includes changes in the kinetics of acute-phase proteins (APPs). " 09/01/1994 - "A weekly study of various inflammatory markers (acute phase proteins, leucocytes and platelets) demonstrated that no inflammatory reaction had occurred after the first two weeks of infection, but that there was a significant increase in acute phase proteins after three and four weeks. "
4.	Neoplasms (Cancer) 01/01/2004 - "It is a stimulus for search of other biochemical indicators, among others determinations of acute phase proteins, helpful in head and neck cancers diagnostics and prognosis. " 04/01/2010 - "However, further studies are required to define the potential clinical application of these acute-phase protein cancer-specific modifications as possible cancer diagnostic or monitoring tools." 01/01/2009 - "In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. " 12/01/1993 - "This study has evaluated the relationship between tumor growth and induction of acute-phase proteins. " 01/01/1989 - "The study of the response of MLTs to specific acute-phase stimuli may make possible a better understanding of the basis for coordinated expression of acute-phase reactants and of the variable phenotypes associated with cancers."
5.	Pain (Aches) 01/01/2000 - "These include acute phase reactants, disability, pain, patient global assessment, physician global assessment, swollen joint count, tender joint count and radiographic changes of joints in any trial of one year or longer [Tugwell 1993], and the change in pooled disease index (DI). " 01/01/2000 - "These include Acute Phase Reactants, Disability, Pain, Patient Global Assessment, Physician Global Assessment, Swollen joint count, Tender joint count and radiographic changes of joints in any trial of 1 year or longer [Tugwell 1993], and the change in pooled disease index. " 01/01/1997 - "This set of measures comprises: pain;patient global assessmentphysical disability;swollen joints;tender joints;acute phase reactants;physician (assessor) global assessment; and, in studies of 1 or more years duration,radiographs of joints. " 05/01/1995 - "Recent international efforts have resulted in consensus over a minimum (WHO/ILAR) core set of endpoints in RA trials: pain, patient and physician (assessor) global assessment, physical disability, swollen joint count, tender joint count, acute phase reactants; and for studies of one or more years' duration: radiographs of joints. " 09/01/1994 - "This core set includes the following measures: pain, patient global assessment, physical disability, swollen joints, tender joints, acute phase reactants, and physician global assessment; in studies of one or more years' duration, radiographs of joints should be performed."

Related Drugs and Biologics

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2.	C-Reactive Protein
3.	Cytokines
4.	Fibrinogen (Factor I)
5.	Interleukin-1 (Interleukin 1)
6.	Serum Amyloid A Protein (Serum Amyloid A)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Interleukin-10 (Interleukin 10)
9.	Blood Proteins (Serum Proteins)
10.	Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Renal Dialysis (Hemodialysis)
3.	Radiotherapy
4.	Transplantation (Transplant Recipients)
5.	Hepatectomy