Actins (F Actin)

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Also Known As:

Networked: 1881 relevant articles (23 outcomes, 114 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Laing, Nigel G: 9 articles (09/2010 - 09/2003)
2.	Danenberg, Peter V: 9 articles (10/2008 - 05/2002)
3.	Danenberg, Kathleen D: 7 articles (10/2008 - 05/2002)
4.	Brabender, Jan: 7 articles (05/2006 - 05/2002)
5.	Bucki, Robert: 5 articles (01/2015 - 10/2005)
6.	Kelm, Robert J: 5 articles (09/2014 - 06/2002)
7.	Elmendorf, Jeffrey S: 5 articles (05/2014 - 11/2006)
8.	Su, Yunchao: 5 articles (08/2013 - 01/2006)
9.	Kondrikov, Dmitry: 5 articles (08/2013 - 01/2006)
10.	Mohan, Rajiv R: 5 articles (01/2013 - 07/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "To our knowledge, this is the first study managing to distinguish cancer cells with different aggressiveness based on quantitative analysis of F-actin distribution patterns. " 01/01/2009 - "In this study, we report evidence of the damage effects of sonodynamic therapy (SDT) on a novel intracellular target, cytoskeletal F-actin, that has great importance for cancer treatment. " 02/01/1996 - "Immunohistochemical study using alpha-actin smooth muscle antibody disclosed bizarre tumor cells with "dendritic" appearance, to our knowledge, never described thus far. " 01/01/1988 - "This study confirms our previous observations in human tumors and shows, for the first time, that alpha-sr and alpha-sm actins can be present in the same neoplastic cell in vivo." 12/17/2015 - "Gamma-actin is involved in regulating centrosome function and mitotic progression in cancer cells."
2.	Fibrosis (Cirrhosis) 12/01/2014 - "The PI3KDM hearts displayed increased expression of disease markers, increased myocardial fibrosis and matrix metalloproteinase (MMP) activity, depolymerization of intracellular F-actin, loss of phospho(threonine-308)-Akt, and normalization of phospho-Erk1/2 signaling. " 05/01/2009 - "One possible mechanism by which ATLa restrained fibrosis was suggested by the finding that BLM-induced myofibroblast accumulation/differentiation in the lung parenchyma was also reduced by both simultaneous and posttreatment with the analog (alpha-actin immunohistochemistry). " 03/01/2009 - "After chronic CCl(4) administration, fibrosis was less apparent, with reduced expression of smooth-muscle alpha-actin-positive cells in the livers of S1P(2)-deficient mice, suggesting that S1P(2) inactivation ameliorated CCl(4)-induced fibrosis due to the decreased accumulation of hepatic stellate cells. " 11/01/2007 - "Their differentiation into myofibroblasts, marked by increased expression of smooth muscle-specific alpha-actin (alpha-SMA), is believed to be important in wound healing and fibrosis. " 12/29/2006 - "Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis."
3.	Necrosis 07/01/2010 - "A biphasic change in F-actin may exist during apoptosis, an initial polymerization and a subsequent depolymerization, but F-actin may be not a necessary component of the process of necrosis in the noise-damaged OHCs." 07/01/2010 - "There was no detectable F-actin change in both the corresponding cuticular plates and the stereocilia in the OHCs undergoing necrosis. " 07/01/2010 - "To observe the changes of filamentous-actin (F-actin) during process of apoptosis and necrosis in hair cells, and investigate the early mark for hair cells pathology following noise exposure. " 11/01/2006 - "Quinazoline, at micromolar concentrations, induced morphological changes and necrosis of B16 cells, and at nanomolar concentrations it produced changes of F-actin cytoskeleton. " 06/01/2004 - "cereus leads to disruption of the F-actin network and necrosis. "
4.	Inflammation 01/01/2012 - "We performed immunohistochemistry to assay F-actin accumulation, neovascularization, proliferation, and inflammation. " 01/01/2008 - "These results identify a novel role for the biophysical association of F-actin in the crosstalk between neuro-inflammatory mediators and mast cells and may be an important target for therapeutic modalities in allergic inflammation." 01/01/2006 - "Inflammation impaired contractility further than Ca2+ signal attenuation, which could be related to the decrease in F-actin that was detected in cholecystitic smooth muscle cells. " 03/01/2010 - "We analyzed 16 liver biopsy samples from eight patients, paired before treatment and after clinical remission, performed an immunohistochemical study with anti-alpha actin smooth muscle antibody and graded fibrosis and inflammation on a scale of 0-4 (Batts and Ludwig scoring system). " 05/27/2009 - "Our results show that the overexpression of huHSP27 in Kupffer cells of the liver may be responsible for the protection against hepatic IRI in vivo by reducing necrosis and apoptosis and by stabilizing F-actin with subsequent reductions in inflammation and proinflammatory neutrophil infiltration. "
5.	Shock 01/01/2012 - "Immediately after the heat shock, cells began a process of fast degradation, and, in the first 24 h, cultures showed decreased viability, alterations in cell morphology and F-actin cytoskeleton organization, significant reduction in the number of adherent cells, most of them in a process of late apoptosis, and an altered gene expression profile. " 12/01/1998 - "We suggest that prior heat shock ameliorates the F-actin response to ischemic stress by suppressing the HSP27 dephosphorylation/granulation; this prolongs a sojourn in the cytosol of phosphorylated HSP27, which protects microfilaments from the disruption and aggregation." 08/01/2009 - "Heat-shock-driven pulse-chase expression experiments showed that WTS-1 regulates the localization of newly synthesized apical actins. " 03/01/2009 - "The ratio of Triton-soluble to -insoluble actin also increased after hypotonic shock, suggesting that the measured increase in F-actin is primarily due to de novo polymerization and formation of short actin filaments, i.e., actin oligomers. " 02/01/2009 - "However, in the intestine, significant loss of F-actin and increase of globular actin was seen from 15 min after shock. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Antibodies
3.	DNA (Deoxyribonucleic Acid)
4.	Adenosine Triphosphate (ATP)
5.	Immunoglobulin G (IgG)
6.	Immunoglobulin A (IgA)
7.	Myosin Heavy Chains (Myosin Heavy Chain)
8.	Transforming Growth Factor beta (TGF-beta)
9.	Procollagen
10.	Matrix Metalloproteinase 2 (Gelatinase A)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Chemoprevention
4.	Transplants (Transplant)
5.	Aftercare (After-Treatment)