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Ectopic ACTH Syndrome

Symptom complex due to ACTH production by non-pituitary neoplasms.
Also Known As:
ACTH Syndrome, Ectopic; ACTH Syndromes, Ectopic; Ectopic ACTH Syndromes; Syndrome, Ectopic ACTH; Syndromes, Ectopic ACTH
Networked: 357 relevant articles (18 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pituitary ACTH Hypersecretion
2. Cushing Syndrome
3. Neoplasms (Cancer)
4. Carcinoma (Carcinomatosis)
5. Addison Disease (Addison's Disease)

Experts

1. Hirata, Yukio: 7 articles (01/2015 - 12/2005)
2. Kageyama, Kazunori: 5 articles (03/2020 - 01/2009)
3. Izumiyama, Hajime: 5 articles (01/2011 - 12/2005)
4. Oki, Yutaka: 4 articles (03/2020 - 12/2005)
5. Young, William F: 4 articles (02/2015 - 04/2004)
6. Doi, Masaru: 4 articles (01/2015 - 12/2005)
7. Tani, Yuji: 4 articles (01/2015 - 03/2008)
8. Sakihara, Satoru: 4 articles (01/2014 - 01/2009)
9. Suda, Toshihiro: 4 articles (01/2014 - 01/2009)
10. Bertagna, X: 4 articles (07/2008 - 04/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ectopic ACTH Syndrome:
1. Adrenocorticotropic Hormone (ACTH)FDA Link
2. Hydrocortisone (Cortisol)FDA LinkGeneric
3. Octreotide (Sandostatin)FDA LinkGeneric
4. Dexamethasone (Maxidex)FDA LinkGeneric
5. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
6. GlucocorticoidsIBA
7. SteroidsIBA
8. Ketoconazole (Nizoral)FDA LinkGeneric
9. Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
10. Somatostatin Receptors (Somatostatin Receptor)IBA
01/01/2002 - "Ectopic ACTH syndrome: discrepancy between somatostatin receptor status in vivo and ex vivo, and between immunostaining and gene transcription for POMC and CRH."
04/01/1994 - "Somatostatin receptor scintigraphy and the ectopic ACTH syndrome--the solution or just another test?"
02/01/2012 - "This case report demonstrates the management of ectopic ACTH-syndrome by molecularly -targeted therapy with dopamine receptor -agonists as well as improved detection of the ectopic ACTH source by novel imaging modalities, such as [(68)Ga-DOTA]-TATE PET specifically targeting somatostatin receptor subtype-2 with high affinity."
10/01/2006 - "We concluded that: 1) measurement of late-night or bedtime salivary cortisol is a useful approach to screen for Cushing's syndrome; 2) measurement of suppressed plasma ACTH by immunometric assay is useful to differentiate ACTH-dependent and -independent Cushing's syndrome; 3) inferior petrosal sinus sampling for ACTH should be performed in patients with ACTH-dependent hypercortisolism in whom a pituitary magnetic resonance imaging is normal or equivocal (in the absence of a pituitary ACTH gradient, prolactin levels should be measured to confirm the integrity of venous sampling); 4) computed tomography of the chest and abdomen and somatostatin receptor scintigraphy should be performed in patients with the occult ectopic ACTH syndrome; and 5) patients with Cushing's disease should be referred to a neurosurgeon with extensive experience operating on corticotroph microadenomas. "

Therapies and Procedures

1. Adrenalectomy
2. Therapeutics
3. Intravenous Injections
4. Combination Drug Therapy (Combination Chemotherapy)
5. Surgical Instruments (Clip)