Acrylonitrile

01/01/2021 - "In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. "
05/20/2016 - "[Clinical analysis on 473 cases of occupational acute acrylonitrile poisoning]."
06/01/2010 - "[Clinical analysis of occupational acute acrylonitrile poisoning]."
05/01/2006 - "[Parkinson's syndrome after acute severe acrylonitrile poisoning in one patient]."
02/01/2005 - "[56 cases of acute acrylonitrile poisoning]."

10/01/2001 - "14-WEEK STUDY: Groups of 10 male and 10 female mice were administered 0, 5, 10, 20, 40, or 60 mg acrylonitrile/kg body weight in deionized water by gavage, 5 days per week, for 14 weeks. "
06/24/2002 - "At 500 ppm, acrylonitrile reduced body weight gain and food intake of the first generation parental rats (F0). "
02/14/1975 - "Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. "
05/01/1977 - "Adult female mice, male rats, female hamsters and male guinea pigs received various doses of styrene (150-1000 mg/kg of body weight) and acrylonitrile (20-80 mg/kg of body weight) intraperitoneally. "
01/01/1994 - "A study by the author on rats showed that for concentrations up to 15 mg/kg body weight 73% of acrylonitrile administered intraperitoneally is eliminated as cyanoethylmercapturic acid, derived from the direct conjugation of acrylonitrile with glutathione. "

12/01/2008 - "The epidemiology studies included in this review have been published since 1970 and were identified through Ovid and MEDLINE retrieval services using search words "acrylonitrile and cancer". "
10/01/2001 - "Under the conditions of this 2-year gavage study, there was clear evidence of carcinogenic activity of acrylonitrile in male and female B6C3F1 mice based on increased incidences of forestomach and harderian gland neoplasms. "
10/01/1999 - "To examine the association between exposure to acrylonitrile (AN) and cancer mortality by performing an independent and extended historical cohort study of workers from a chemical plant in Lima, Ohio included in a recent NCI-NIOSH study. "
01/01/1999 - "There have been 12 epidemiology studies of 37,352 workers exposed to acrylonitrile which evaluate CNS cancers. "
01/01/1999 - "CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology studies."

06/01/2021 - "Epidemiology of lung cancer among acrylonitrile-exposed study populations: A meta-analysis."
01/01/2006 - "The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. "
06/01/2004 - "Exposure to acrylonitrile was associated in our study with risk of lung cancer. "
02/01/2001 - "The present study provides additional analyses of data obtained earlier on lung cancer risk among workers with acrylonitrile exposure. "
12/15/1990 - "Several epidemiology studies provide suggestive evidence for an association of lung cancer in workers exposed to acrylonitrile; however, smoking may be a contributing factor and therefore the role of acrylonitrile as a causative factor is unclear. "

09/01/2009 - "Studies have demonstrated that the induction of oxidative stress may be involved in brain tumor induction in rats by acrylonitrile. "
01/01/2003 - "Studies in our laboratory and others have indicated that acrylonitrile (VCN) induces acute and chronic neurotoxicity and brain tumors in animal models. "
01/01/1998 - "Therefore, it is recommended to conduct an additional long-term inhalation carcinogenicity study with acrylonitrile in mice, as well as studies into the mechanism by which acrylonitrile induces (brain) tumors in rats (genetic versus epigenetic)."
01/01/2013 - "Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat."
10/01/2005 - "Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity."