HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Acrodynia (Swift's Disease)

A condition seen primarily in childhood, most often resulting from chronic exposure to MERCURY COMPOUNDS which may result in encephalopathy and POLYNEUROPATHY. Clinical features include pain, swelling and pinkish discoloration of the fingers and toes, weakness in the extremities, extreme irritability, HYPERESTHESIA, and alterations in level of consciousness. (From Menkes, Textbook of Child Neurology, 5th ed, p603)

Also Known As:

Swift's Disease; Acrodynic Erythema; Chronic Childhood Mercurialism; Feer's Disease; Childhood Mercurialism, Chronic; Childhood Mercurialisms, Chronic; Chronic Childhood Mercurialisms; Erythema, Acrodynic; Feers Disease; Mercurialism, Chronic Childhood; Swifts Disease; Feer Disease; Pink Disease; Swift Disease

Networked: 96 relevant articles (5 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acrodynia (Swift's Disease)
2.	Mercury Poisoning (Poisoning, Mercury)
3.	Hypertension (High Blood Pressure)
4.	Poisoning
5.	Hypersensitivity (Allergy)

Experts

1.	Deth, Richard: 2 articles (09/2013 - 10/2012)
2.	Yeter, Deniz: 2 articles (09/2013 - 10/2012)
3.	Kern, Janet: 1 article (01/2014)
4.	Geier, David: 1 article (01/2014)
5.	Geier, Mark: 1 article (01/2014)
6.	King, Paul: 1 article (01/2014)
7.	Haley, Boyd: 1 article (01/2014)
8.	Sykes, Lisa: 1 article (01/2014)
9.	Hooker, Brian: 1 article (01/2014)
10.	Kuo, Ho-Chang: 1 article (09/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acrodynia:

1.	MercuryIBA 06/29/1950 - "[Acrodynia; a review, and report of a case, with mercury in the urine, cured following treatment with dimercaptopropanol]." 09/01/2013 - "During the infantile acrodynia epidemic, only 1 in 500 children developed acrodynia whereas mercury exposure was very common due to the use of teething powders. " 08/01/2012 - "Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis. " 03/01/2012 - "We present a case of a 3-year-old girl with acrodynia secondary to toxic exposure to elemental mercury in the home environment." 03/01/2012 - "Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the modern world because of regulations to eliminate mercury from personal care products, household items, medications, and vaccinations. "
2.	calomelIBA 08/17/1957 - "A biochemical approach to calomel-induced mercurialism and to the aetiology of pink disease." 05/25/1957 - "Calomel and pink disease: preliminary report." 01/01/1953 - "[A case of acrodynia after ingestion of calomel]." 10/01/2012 - "As was experienced with the infantile acrodynia epidemic, only 1 in 500 children developed the disease although pediatric mercury exposure was nearly ubiquitous due to the use calomel teething powders. " 12/01/1959 - "The effect of calomel on plasma epinephrine in the rat and the relationship to mechanisms in pink disease."
3.	Dimercaprol (B.A.L.)FDA Link 07/01/1951 - "Dimercaprol in the treatment of acrodynia." 05/01/1948 - "Ingestion of mercury as a probable cause of acrodynia and its treatment with dimercaprol; report of two cases." 12/01/1949 - "Mercury poisoning from calomel producing subacute acrodynia and its treatment with dimercaprol; report of a case." 03/01/1952 - "Report of two cases of acrodynia appearing after calomel therapy but without excretion of mercury in the urine and cured with B.A.L."
4.	Penicillins (Penicillin)FDA Link 05/01/1953 - "[A case of acrodynia cured with penicillin]." 10/17/1953 - "Effect of penicillin on pink disease." 12/01/1950 - "[Acrodynia; a case treated by penicillin]."
5.	Adrenocorticotropic Hormone (ACTH)FDA Link 02/04/1958 - "[Efficacy of ACTH treatment in a case of acrodynia]." 02/04/1956 - "[Acrodynia and ACTH]."
6.	Vitamin B 6IBA 01/01/2012 - "In 1934, Paul György showed that the factor which cured 'rat acrodynia' was vitamin B(6). "
7.	Epinephrine (Adrenaline)FDA LinkGeneric 03/10/1951 - "Pink disease: the manifestation in older children and the estimation of the blood adrenaline content." 12/01/1959 - "The effect of calomel on plasma epinephrine in the rat and the relationship to mechanisms in pink disease." 02/01/1959 - "The effect of mercurous chloride (calomel) and epinephrine (sympathetic stimulation) on rats; the importance of the findings to mechanisms in infantile acrodynia (pink disease)."
8.	Thimerosal (Thiomersal)IBA 01/15/2004 - "In rare cases, thimerosal has caused systemic immune reactions including acrodynia. " 01/01/2014 - "Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. "
9.	Pyridoxine (Pyridoxin)FDA LinkGeneric 11/01/1952 - "Factors affecting the development of acrodynia in pyridoxine-deficient rats." 08/01/1951 - "Production of acrodynia in mice fed diets low in pyridoxine."
10.	Penicillamine (Cuprimine)FDA Link 01/01/1968 - "Acrodynia treated with D-penicillamine." 04/01/1967 - "[Acrodynia (comparative study of various chelating agents; curable agranulocytosis during treatment by penicillamine)]."

Therapies and Procedures

1.	Nephrectomy 08/01/1953 - "Renal thrombosis complicating pink disease: cure by nephrectomy."