Aconitine

A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.

Also Known As:

Acetylbenzoyl-aconine; Acetylbenzoyl aconine; Acetylbenzoylaconine; Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-

Networked: 466 relevant articles (30 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Peng, Cheng: 6 articles (08/2022 - 11/2009)
2.	Farraj, Aimen K: 6 articles (12/2020 - 12/2009)
3.	Haykal-Coates, Najwa: 6 articles (12/2020 - 12/2009)
4.	Hazari, Mehdi S: 6 articles (12/2020 - 12/2009)
5.	Gao, Yue: 5 articles (06/2022 - 01/2018)
6.	Joukar, Siyavash: 5 articles (01/2016 - 12/2013)
7.	Turilova, A I: 5 articles (01/2016 - 05/2003)
8.	Peng, Fu: 4 articles (01/2022 - 01/2020)
9.	Winsett, Darrell W: 4 articles (01/2015 - 12/2009)
10.	Chan, Thomas Y K: 4 articles (04/2009 - 01/2002)

Related Diseases

1.	Ventricular Fibrillation 09/01/1967 - "[Studies on aconitine-ventricular fibrillation. " 02/01/1964 - "STUDIES ON ACONITINE-INDUCED VENTRICULAR FIBRILLATION BY SIMULTANEOUS RECORDING OF ELECTROCARDIOGRAMS AND TRANSMEMBRANE POTENTIALS IN SITU." 01/01/2007 - "Aconitine-induced ventricular fibrillation was induced in hearts isolated from adult rats. " 01/01/2001 - "For assessment of the antiarrhythmic activity in anesthetized rats, we infused aconitine until the occurrence of ventricular fibrillation (VF). " 10/29/1993 - "Several compounds in this series increased the threshold for ventricular fibrillation and refractoriness in myocardially-infarcted anesthetized cata and delayed the onset of aconitine-induced arrhythmias in anesthetized guinea pigs following intravenous dosing. "
2.	Cardiac Arrhythmias (Arrythmia) 01/01/2021 - "Accordingly, in this study, we used a rat model of aconitine-induced ventricular arrhythmia to assess the effects of ALO. " 11/01/2011 - "The aconitine-induced experimental rat model of cardiac arrhythmia has been used in our study. " 06/01/2008 - "The present study established a model of RyR(2) knockdown cardiomyocytes and elucidated the role of RyR(2) in aconitine-induced arrhythmia. " 01/01/1996 - "[The detection and studies on the change of H+ concentration in the regular points of the rabbit suffering from arrhythmia induced by aconitine]." 01/01/2023 - "Ventricular arrhythmia (VA) was induced by aconitine injection into PMs of healthy sheep. "
3.	Atrial Fibrillation 04/01/2007 - "In this study, we examined the effects of NIP-141 on aconitine-induced atrial fibrillation (AF) and rapid atrial pacing-induced atrial effective refractory period (ERP) shortening in dogs. " 03/01/1970 - "[An experimental study on atrial fibrillation--influence of extracardial nerves upon aconitine-atrial fibrillation]." 12/01/1961 - "[Studies on aconitine-induced atrial fibrillation of the young rabbit by the microelectode technic]." 01/01/2004 - "To further exclude the possibility that aconitine application may cause changes in ventricular threshold, atrial fibrillation was induced by pacing techniques in five dogs. " 01/01/2004 - "The enhanced vulnerability was noted following atrial fibrillation, not after aconitine application to the great veins, which did not cause atrial fibrillation. "
4.	Ventricular Tachycardia 10/01/2021 - "Integrating proteomic, lipidomic and metabolomic data to construct a global metabolic network of lethal ventricular tachyarrhythmias (LVTA) induced by aconitine." 09/01/2017 - "Vulnerability to ventricular arrhythmias was measured as the threshold dose of aconitine required to produce sustained ventricular tachycardia. " 01/01/2017 - "Aconitine (ACO) is well-known for causing lethal ventricular tachyarrhythmias. " 05/01/2004 - "Hemodynamics in aconitine-evoked ventricular tachycardia was characterized as lower BP, higher BPV, and higher HPV. " 02/01/2004 - "In response to an intravenously infused chemical challenge, aconitine, anhedonic rats exhibited an increased vulnerability to ventricular arrhythmias, as indicated by a reduced threshold for premature ventricular complexes, salvos, and ventricular tachycardia. "
5.	Poisoning 01/01/2002 - "The annual incidence of aconitine poisoning showed a marked decrease from 0.49 to 0.69 [overall 0.60, 95% confidence intervals (CI) 0.34 to 0.99] to 0.10 to 0.22 (overall 0.16, 95% CI 0.03 to 0.46) per 100,000 population (p = 0.024). " 01/01/2020 - "These data about the distribution of aconitine in the antemortem blood and various postmortem body fluids is helpful for future aconitine poisoning death cases." 08/01/2023 - "The poisoning symptoms of the central nervous system and cardiovascular system caused by it are relatively common in China, and there are many studies on cardiovascular system diseases caused by aconitine. " 08/15/2014 - "In this study, we explored the importance of pathological Ca(2+) signaling in aconitine poisoning in vitro and in vivo. " 01/01/2002 - "The objective of this study was to assess the impact of these publicity measures on the incidence of herb-induced aconitine poisoning in the New Territories East, based on the number of admissions to the Prince of Wales Hospital. "

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6.	Calcium Chloride (Calcium Chloride, Anhydrous)
7.	Chloroform (Trichloromethane)
8.	Methylprednisolone
9.	lorcainide
10.	Epinephrine (Adrenaline)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics
3.	Microelectrodes
4.	Oral Administration
5.	Ligation