Renal Tubular Acidosis (Distal Renal Tubular Acidosis)

A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Also Known As:
Distal Renal Tubular Acidosis; Renal Tubular Acidosis, Distal, Autosomal Dominant; Acidosis, Renal Tubular; Acidosis, Renal Tubular, Type I; Acidosis, Renal Tubular, Type II; Classic Distal Renal Tubular Acidosis; Proximal Renal Tubular Acidosis; Renal Tubular Acidosis, Proximal, with Ocular Abnormalities; Renal Tubular Acidosis, Type I; Renal Tubular Acidosis, Type II; Type I Renal Tubular Acidosis; Type II Renal Tubular Acidosis
Networked: 826 relevant articles (17 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Fanconi Syndrome (Syndrome, Fanconi)
2. Glycosuria
3. Osteomalacia
4. Hypophosphatemia
5. Bone Diseases (Bone Disease)


1. Wagner, Carsten A: 14 articles (04/2015 - 03/2002)
2. Cordat, Emmanuelle: 11 articles (08/2014 - 09/2004)
3. Yenchitsomanus, Pa-thai: 10 articles (07/2014 - 07/2002)
4. Reithmeier, Reinhart A F: 10 articles (11/2013 - 09/2004)
5. Sawasdee, Nunghathai: 9 articles (08/2015 - 07/2002)
6. Yenchitsomanus, Pa-Thai: 9 articles (08/2015 - 04/2004)
7. Schwartz, George J: 8 articles (07/2013 - 06/2003)
8. Alper, Seth L: 7 articles (04/2011 - 01/2002)
9. Toye, Ashley M: 7 articles (07/2008 - 01/2002)
10. Akkarapatumwong, Varaporn: 6 articles (08/2015 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Renal Tubular Acidosis:
1. AlkaliesIBA
2. Furosemide (Lasix)FDA LinkGeneric
3. Uric Acid (Urate)IBA
4. PotassiumIBA
5. FludrocortisoneIBA
6. dirhodium tetraacetate (DRTA)IBA
7. CalciumIBA
8. MagnesiumIBA
9. Quaternary Ammonium Compounds (Ammonium)IBA
10. maleic acid (maleate)IBA
03/01/1986 - "Microperfusion study of proximal tubule bicarbonate transport in maleic acid-induced renal tubular acidosis."
12/01/1982 - "Dysfunction of the proximal tubule underlies maleic acid-induced type II renal tubular acidosis."
03/01/1986 - "The observations indicate that proximal renal tubular acidosis (RTA) induced by maleic acid is characterized by impaired lumen-to-blood transport of sodium bicarbonate and chloride but not by increased backflux. "
04/01/1985 - "The metabolic pathogenesis of the complex renal tubular dysfunction of type II renal tubular acidosis and Fanconi's syndrome (RTA II/FS) acutely induced by maleic acid could depend on the occurrence of a positive feedback loop in cells of the proximal renal tubule: impaired mitochondrial oxidation----increased glucose uptake----increased formation and concentration of phosphorylated glycolytic intermediates----limitation on availability of cellular inorganic phosphate----more severely impaired mitochondrial oxidative metabolism. "
12/01/1982 - "To investigate whether dysfunction of the proximal tubule underlies maleic acid-(MA) induced type II ("proximal") renal tubular acidosis (RTA II), we intravenously administered either MA or acetazolamide to eight conscious trained dogs undergoing water diuresis and examined the relationship between fractional solute-free water clearance (Ch2o/GFR), a measure of NaCl reabsorption in the post-proximal nephron, and either fractional urine flow (V/GFR), a measure of total solute rejected by the proximal tubule, or the sum of fractional excretion of Cl- and Ch2o/GFR [(Ccl + Ch2o)/GFR], a measure of proximally rejected solute that is potentially reabsorbable by the thick ascending limb. "

Therapies and Procedures

1. Kidney Transplantation
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Nephrectomy
4. Cerebrospinal Fluid Shunts
5. Jejunoileal Bypass