Acetylglucosaminidase (NAGase)

A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.

Also Known As:

NAGase; Chitobiase; N,N-Diacetylchitobiase; N-Ac-beta-Glucosaminidase; beta-D-Acetamido-2-Deoxyglucosidase; beta-D-N-acetylglucosaminidase; beta-N-Acetylglucosaminidase; N Ac beta Glucosaminidase; N Acetyl beta D glucosaminidase; N,N Diacetylchitobiase; beta D Acetamido 2 Deoxyglucosidase; beta D N acetylglucosaminidase; beta N Acetylglucosaminidase; N-Acetyl-beta-D-glucosaminidase

Networked: 899 relevant articles (24 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Hexosaminidases: 1037
        beta-N-Acetylhexosaminidases: 440
        Acetylglucosaminidase: 899
        alpha-N-acetyl-D-glucosaminidase: 141
        BMN 250: 3
        keratanase II: 2
        4-nitrophenyl-alpha-N-acetylglucosaminidase
        C elegans eng-1 protein
        Drosophila fdl protein
        mouse Ctbs protein
        p67 deglycosylase

Experts

1.	Pyörälä, S: 6 articles (06/2013 - 03/2001)
2.	Dickson, Patricia I: 5 articles (01/2021 - 03/2014)
3.	Simojoki, H: 5 articles (06/2013 - 02/2009)
4.	Medina-Campos, Omar N: 5 articles (02/2008 - 08/2003)
5.	Hernández-Pando, Rogelio: 5 articles (09/2004 - 08/2003)
6.	Pedraza-Chaverrí, José: 5 articles (09/2004 - 08/2003)
7.	Crawford, Brett E: 4 articles (01/2021 - 10/2014)
8.	Kan, Shih-Hsin: 4 articles (01/2021 - 10/2014)
9.	Lawrence, Roger: 4 articles (01/2021 - 10/2014)
10.	Le, Steven Q: 4 articles (01/2021 - 03/2014)

Related Diseases

1.	Mastitis 03/01/1986 - "Inter-quarter evaluation clearly improved each indirect mastitis parameter; NAGase and antitrypsin were better indicators of differences between infected and non-infected quarters than BSA or the somatic cell count." 05/01/1991 - "This study examined effects of repeated episodes of clinical mastitis in chronically infected quarters on milk N-acetyl-beta-D-glucosaminidase activity and duration of clinical signs. " 07/01/1987 - "Studies on induced Klebsiella mastitis with relationships among N-acetyl-beta-D-glucosaminidase, bacterial and somatic cell counts." 05/01/2016 - "Our results indicate that NAGase activity can be used to detect both subclinical and clinical mastitis with a high level of accuracy (0·85 and 0·99). " 05/01/2016 - "Associations between milk NAGase activity and milk somatic cell count (SCC), mastitis causing pathogen, quarter, parity, days in milk (DIM) and season were studied. "
2.	Infections 08/01/1993 - "Does with CAEV but no bacterial udder infection had significantly greater mean SCC and NAGase activity than CAEV-free does without udder infection (P < 0.01). " 11/01/1991 - "The major difference in false positive results associated with experimental infection between the three tests was the more rapid return to negative values of the ELISA following resolution of infection, compared with MCC and NAGase." 07/01/1992 - "The log NAGase was relatively more effective in identifying major from minor pathogen infections, whereas log SCC was better able to differentiate between infected and uninfected classes. " 02/01/2001 - "Bacterial pathogens causing udder infections in Israeli Assaf dairy sheep were identified and changes occurring throughout lactation were monitored to study the correlation between the contaminant and the severity of the infection, as measured by somatic cell count (SCC) and NAGase tests. " 09/01/2019 - "ORF104, which is an N-acetylglucosaminidase found in the ɸMR003 tail, may facilitate phage's infection onto the WTA-null S. "
3.	Nephrotic Syndrome (Syndrome, Nephrotic) 04/01/2012 - "Urinary N-acetyl-beta-D glucosaminidase (NAG) level in idiopathic nephrotic syndrome." 01/01/1999 - "N-acetyl-beta-D-glucosaminidase and beta2-microglobulin: prognostic markers in idiopathic nephrotic syndrome." 01/01/1990 - "Exactly why N-acetyl-beta-D-glucosaminidase (NAG) excretion is increased in patients with nephrotic syndrome with glomerular lesions is poorly understood. " 05/01/1994 - "We incubated an immortalized cell line derived from rat hepatocytes (H4 cells) with serum from Nagase analbuminemic rats (NAR) and rats with passive Heymann nephritis (HN), a model of the nephrotic syndrome. " 07/01/2003 - "Nagase rats with hereditary analbuminemia (NAR) have been used as a model to dissect the effect of primary hypoalbuminemia from that caused by proteinuria in nephrotic syndrome. "
4.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/01/2000 - "The aim of this study was to examine the compromise of proximal tubule cells in steroid-resistant nephrotic syndrome patients with a histologic diagnosis of focal segmental glomerulosclerosis (FSGS) through assessment of the urinary levels of beta 2-microglobulin (beta 2M) and N-acetyl-beta-D-glucosaminidase (NAG) during active disease and remission over a follow-up period of 3 years. " 10/01/1998 - "Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and retinol-binding protein (RBP), sensitive markers of renal tubular damage and dysfunction respectively, were evaluated in paired remission and relapse urine samples from 16 patients (median age 12 years), with minimal change nephrotic syndrome (MCNS), in single samples from 5 nephrotic patients (median age 12 years) with focal segmental glomerulosclerosis (FSGS) and in 183 normal controls aged 2-16 years. "
5.	Body Weight (Weight, Body) 08/01/2023 - "Changes in urine volume (UV), body weight, estimated glomerular filtration rate (eGFR), and urine N-acetyl-beta-d-glucosaminidase (uNAG) levels before and after ARNI initiation were investigated. " 07/01/2013 - "Our results showed that the oral preventive or therapeutic treatment with α,β-amyrin significantly reduced disease activity, body weight loss, colonic damage, as well as colonic myeloperoxidase and N-acetylglucosaminidase activities. " 08/01/1988 - "Under the conditions of intravenous pyelography, we observed directly after the administration of all substances (3.5 mg/kg body weight) an enhanced enzymuria of gamma-glutamyl transpeptidase and N-acetyl-beta-D-glucosaminidase. " 07/01/1988 - "At weekly intervals, renal excretion of creatinine/24 hrs and N-acetyl-beta-D-glucosaminidase activity in urine (NAG) were determined as well as body weights. " 07/01/1992 - "After 6 days of daily intraperitoneal injections of AmB-DC, decreased body weight and glomerular filtration rate as well as increased degree of diuresis, uremia, microalbuminuria, and N-acetyl-beta-D-glucosaminidase excretion in urine were noted. "

Related Drugs and Biologics

1.	Creatinine
2.	Urea (Carbamide)
3.	Proteins (Proteins, Gene)
4.	Albumins
5.	Nitrogen
6.	Glucuronidase
7.	Retinol-Binding Proteins (Retinoid Binding Proteins)
8.	Acetylglucosaminidase (NAGase)
9.	Serum Albumin
10.	Lipids

Related Therapies and Procedures

1.	Therapeutics
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Transplantation
5.	Peritoneal Dialysis