HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Acetylglucosaminidase (NAGase)

Subscribe to New Research on Acetylglucosaminidase

A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.

Also Known As:

NAGase; Chitobiase; N,N-Diacetylchitobiase; N-Ac-beta-Glucosaminidase; beta-D-Acetamido-2-Deoxyglucosidase; beta-D-N-acetylglucosaminidase; beta-N-Acetylglucosaminidase; N Ac beta Glucosaminidase; N Acetyl beta D glucosaminidase; N,N Diacetylchitobiase; beta D Acetamido 2 Deoxyglucosidase; beta D N acetylglucosaminidase; beta N Acetylglucosaminidase; N-Acetyl-beta-D-glucosaminidase

Networked: 767 relevant articles (20 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Glycoside Hydrolases: 275
      - Hexosaminidases: 701
        beta-N-Acetylhexosaminidases: 414
        Acetylglucosaminidase: 767
        alpha-N-acetyl-D-glucosaminidase: 68
        keratanase II: 2
        4-nitrophenyl-alpha-N-acetylglucosaminidase
        C elegans eng-1 protein
        Drosophila fdl protein
        mouse Ctbs protein
        p67 deglycosylase

Experts

1.	Pyörälä, S: 6 articles (06/2013 - 03/2001)
2.	Simojoki, H: 5 articles (06/2013 - 02/2009)
3.	Medina-Campos, Omar N: 5 articles (02/2008 - 08/2003)
4.	Pedraza-Chaverrí, José: 5 articles (09/2004 - 08/2003)
5.	Hernández-Pando, Rogelio: 5 articles (09/2004 - 08/2003)
6.	Taponen, S: 4 articles (06/2013 - 02/2009)
7.	Chirino, Yolanda I: 4 articles (03/2008 - 04/2004)
8.	Barrera, Diana: 4 articles (04/2004 - 08/2003)
9.	Maldonado, Perla D: 4 articles (04/2004 - 08/2003)
10.	Ito, Seiki: 3 articles (02/2014 - 05/2003)

Related Diseases

1.	Mastitis 03/01/1986 - "Inter-quarter evaluation clearly improved each indirect mastitis parameter; NAGase and antitrypsin were better indicators of differences between infected and non-infected quarters than BSA or the somatic cell count." 11/01/1997 - "This study examined the capability of milk somatic cell count (SCC) and NAGase activity to discriminate between quarters that had been cured versus those that had not been cured at 4 wk after antimicrobial therapy for clinical mastitis. " 05/01/1991 - "This study examined effects of repeated episodes of clinical mastitis in chronically infected quarters on milk N-acetyl-beta-D-glucosaminidase activity and duration of clinical signs. " 07/01/1987 - "Studies on induced Klebsiella mastitis with relationships among N-acetyl-beta-D-glucosaminidase, bacterial and somatic cell counts." 06/01/2013 - "Milk APP concentrations and NAGase activity in clinical mastitis caused by different udder pathogens were studied. "
2.	Infection 08/01/1993 - "Does with CAEV but no bacterial udder infection had significantly greater mean SCC and NAGase activity than CAEV-free does without udder infection (P < 0.01). " 11/01/1991 - "The major difference in false positive results associated with experimental infection between the three tests was the more rapid return to negative values of the ELISA following resolution of infection, compared with MCC and NAGase." 07/01/1992 - "The log NAGase was relatively more effective in identifying major from minor pathogen infections, whereas log SCC was better able to differentiate between infected and uninfected classes. " 08/01/2004 - "Effect of subclinical intramammary infection on somatic cell counts, NAGase activity and gross composition of goats' milk." 07/01/1992 - "Substitution of herd averages for log SCC and log NAGase for the herd variables resulted in significant differences between predicted and observed herd infection probabilities."
3.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/01/2000 - "The aim of this study was to examine the compromise of proximal tubule cells in steroid-resistant nephrotic syndrome patients with a histologic diagnosis of focal segmental glomerulosclerosis (FSGS) through assessment of the urinary levels of beta 2-microglobulin (beta 2M) and N-acetyl-beta-D-glucosaminidase (NAG) during active disease and remission over a follow-up period of 3 years. " 10/01/1998 - "Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and retinol-binding protein (RBP), sensitive markers of renal tubular damage and dysfunction respectively, were evaluated in paired remission and relapse urine samples from 16 patients (median age 12 years), with minimal change nephrotic syndrome (MCNS), in single samples from 5 nephrotic patients (median age 12 years) with focal segmental glomerulosclerosis (FSGS) and in 183 normal controls aged 2-16 years. "
4.	Body Weight (Weight, Body) 02/01/2002 - "When alloxan diabetic rats on high-calorie chow were treated with SZ, the hyperglycemic symptoms were improved, the blood lipid levels were improved, the ratio of kidney over body weight and the blood N-acetyl-beta-D-glucosaminidase (NAG) activity were lowered. " 08/01/1988 - "Under the conditions of intravenous pyelography, we observed directly after the administration of all substances (3.5 mg/kg body weight) an enhanced enzymuria of gamma-glutamyl transpeptidase and N-acetyl-beta-D-glucosaminidase. " 07/01/1988 - "At weekly intervals, renal excretion of creatinine/24 hrs and N-acetyl-beta-D-glucosaminidase activity in urine (NAG) were determined as well as body weights. " 07/01/1992 - "After 6 days of daily intraperitoneal injections of AmB-DC, decreased body weight and glomerular filtration rate as well as increased degree of diuresis, uremia, microalbuminuria, and N-acetyl-beta-D-glucosaminidase excretion in urine were noted. " 12/01/2002 - "Animals that received a daily intraperitoneal injection of gentamicin (100 mg/kg body weight) showed lower GFR and renal blood flow (RBF) and higher urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) than control rats. "
5.	Proteinuria 09/01/2004 - "The aim of the study was to examine the effect of omega-3 therapy on renal vascular function in relation to proteinuria and urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG). " 04/01/2012 - "Correlation between glomerular filtration rate and urinary N acetyl-beta-D glucosaminidase in children with persistent proteinuria in chronic glomerular disease." 06/01/2010 - "Clinical parameters such as estimated GFR (eGFR), proteinuria and urinary N-acetyl-beta-D-glucosaminidase (NAG) were measured. " 01/01/1998 - "The 24-hour urinary N-acetyl-beta-D-glucosaminidase (NAG) concentration was measured in 167 patients with dissimilar renal disease, function, and proteinuria. " 11/29/1996 - "Origin and significance of urinary N-acetyl-beta, D-glucosaminidase (NAG) in renal patients with proteinuria."

Related Drugs and Biologics

1.	Creatinine
2.	Urea (Carbamide)
3.	Nitrogen
4.	Acetylglucosaminidase (NAGase)
5.	Serum Albumin
6.	Glucuronidase
7.	beta 2-Microglobulin (beta 2 Microglobulin)
8.	Carrier Proteins (Binding Protein)
9.	Vitamin A (Retinol)
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Peritoneal Dialysis
5.	Aftercare (After-Treatment)