HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Acetylgalactosamine

Subscribe to New Research on Acetylgalactosamine

The N-acetyl derivative of galactosamine.

Also Known As:

2-Acetamido-2-D-galactopyranose; 2-Acetamido-2-Deoxy-D-Galactose; 2-Acetamido-2-Deoxygalactose; N-Acetyl-D-Galactosamine; 2 Acetamido 2 D galactopyranose; 2 Acetamido 2 Deoxy D Galactose; 2 Acetamido 2 Deoxygalactose; N Acetyl D Galactosamine; Galactose, 2-(acetylamino)-2-deoxy-

Networked: 225 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 4088
- Amino Sugars: 30
  - Hexosamines: 62
    - Galactosamine: 1116
      - Acetylgalactosamine: 225
        benzyl-alpha-N-acetylgalactosamine: 14
        N-acetylgalactosamine 6-sulfate: 2
        N-acetylgalactosamine 4-sulfate: 1
        N-acetylgalactosaminitol: 1
        N-bromoacetyl-beta-D-galactosamine tetra-O-acetate: 1
        1-methylseleno-N-acetylgalactosamine
        2-acetamido-2-deoxy-D-galactolactone
        2-dansylaminoethyl-N-acetylgalactosamine
        3-O-alpha-N-acetylgalactosaminosyl-N-acetylgalactosamine
        4-nitrophenyl-2-acetamido-2-deoxygalactopyranoside
        Ac(4)GalNAz
        acetylgalactosaminylserine
        asialo-galactosyl-acetylgalactosamine
        asparaginyl-N-acetylgalactosamine
        beta-D-galactosyl(1-3)-4-nitrophenyl-N-acetyl-alpha-D-galactosamine
        dTDP-3-acetamido-3,6-dideoxygalactose
        N-acetylgalactosamine 4,6-bisulfate
        N-acetylgalactosamine 6-O-2-aminoethylphosphonate
        N-acetylgalactosamine-1-phosphate
        N-acetylgalactosamine-bovine serum albumin conjugate
        N-acetylgalactosamine-dextran conjugate
        N-bromoacetyl-beta-D-galactosylamine
        N-fluoroacetylgalactosamine
        O-(2-acetamido-2-deoxy-alpha-galactopyranosyl)-(1-3)-N-acetylserine methyl ester
        phenyl 2-acetamido-2-deoxy-4-O-sulfonatogalactopyranoside
        phenyl alpha-N-acetylgalactosaminide
        uridine 5'-diphosphate 2-acetamido-2,4-dideoxy-4-fluorogalactopyranose

Experts

1.	Julian, Bruce A: 3 articles (01/2014 - 05/2007)
2.	Moldoveanu, Zina: 3 articles (01/2014 - 05/2007)
3.	Novak, Jan: 3 articles (01/2014 - 05/2007)
4.	Berois, Nora: 3 articles (01/2009 - 03/2006)
5.	Osinaga, Eduardo: 3 articles (01/2009 - 03/2006)
6.	Jarroll, Edward L: 3 articles (03/2007 - 04/2003)
7.	van Keulen, Harry: 3 articles (03/2007 - 03/2002)
8.	Lopez, Alex B: 3 articles (03/2007 - 03/2002)
9.	Brooks, S A: 3 articles (09/2001 - 01/2000)
10.	Raska, Milan: 2 articles (01/2014 - 05/2007)

Related Diseases

1.	Neoplasms (Cancer) 10/10/1968 - "[Studies on the detectability of N-acetyl-D-galactosamine in human tumors and ultimate medical consequences of the findings]." 01/01/1968 - "[Supplementary studies on the problem of tumor specificity of N-acetyl-D-galactosamine in the rat]." 01/01/2015 - "The lectin found in the tubers of the Winter Aconite (Eranthis hyemalis) plant is an N-acetyl-D-galactosamine specific Type II Ribosome Inactivating Protein (RIP); Type II RIPs have shown anti-cancer properties, and hence have potential as therapeutic agents. " 02/01/2005 - "N-acetyl-D-galactosamine residues, especially those carried by atypical MUC1 protein, in aggressive cancer cells may serve as an important drug target." 06/20/2003 - "Instead, we showed that the cognate 22.1.1 epitope is identical with the tumor-associated O-linked glycan Tn (N-acetyl-d-galactosamine, GalNAc). "
2.	Carcinoma (Carcinomatosis) 07/01/1990 - "Comparative analysis on the normal breast indicated that PNA affinity histochemistry would be useful to the understanding of the metabolism of N-acetyl-D-galactosamine during the development of normal breast and histological origin of breast carcinoma." 07/01/1989 - "The changes of DBA and SBA showed increased N-acetyl-D-galactosamine in mucus carcinoma. " 01/01/1988 - "The data suggest that the determinant recognized is a core structure which is normally not exposed due to chain elongation at C-3 of the N-acetylgalactosamine, which appears to be less frequent in carcinoma cells than in normal cells." 09/30/1994 - "The results demonstrate that oral squamous cell carcinomas mainly express accessible binding sites for lactosylated neoglycoprotein (90%) while few carcinomas expressed mild amount of N-acetyl-D-galactosamine specific binding sites (40%). " 04/15/2000 - "Order and maximum incorporation of N-acetyl-D-galactosamine into threonine residues of MUC2 core peptide with microsome fraction of human-colon-carcinoma LS174T cells."
3.	Neoplasm Metastasis (Metastasis) 01/01/2013 - "In this study, to clarify the role of E-units in the metastasis and to search for potential molecular targets for anticancer drugs, the isolation and characterization of Lewis lung carcinoma (LLC) cells stably downregulated by the knockdown for the gene encoding N-acetylgalactosamine 4-O-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), which is responsible for the formation of E-units in CS chains, were performed. " 10/01/1996 - "Prognosis is associated with the cell type, presence of lymph node metastases and heparin-binding lectin (HBL), certain cytometric and structural features, and binding of macrophage migration inhibitory factor (MIF) and beta-N-acetyl-D-galactosamine (beta-GalNAc). " 01/01/1993 - "We conclude that binding sites with specificity for maltose and N-acetylgalactosamine are present on human RCC and their corresponding metastases." 10/01/1992 - "Tumor progression in vivo: increased soybean agglutinin lectin binding, N-acetylgalactosamine-specific lectin expression, and liver metastasis potential." 10/01/2007 - "The lectin recognizes alpha-d-N-acetylgalactosamine (alphaGalNAc) containing epitopes which are only present in cancer cell lines having a high likelihood to undergo metastasis, such as the HT29 cancer colon cell line. "
4.	Adenocarcinoma 05/01/2004 - "In this study we investigated the levels of expression of sialic acid and N-acetylgalactosamine residues on the cell surface of a normal intestinal epithelium cell line, IEC-6, and in two colon adenocarcinoma cell lines with different metastatic potential, Caco-2 and HCT-116. " 01/01/2013 - "Helix pomatia lectin binding indicated that transcytotic vesicles expose aberrant N-acetylgalactosamine glycoconjugates, which is associated with a poor prognosis for a range of metastasizing human adenocarcinomas. " 01/01/2002 - "The expression of the aberrant N-acetylgalactosamine (GalNAc) glycoconjugates, detected by binding of the lectin from Helix pomatia (HPA) is reported to be associated with metastatic competence and poor prognosis in a range of human adenocarcinomas, but the functional significance of the glycoconjugates in metastatic mechanisms is unknown. " 09/28/2001 - "Over-expression of N-acetylgalactosamine glycoproteins as detected by binding of the lectin from Helix pomatia (HPA), is associated with metastatic competence and poor patient prognosis in a range of human adenocarcinomas. " 01/01/1994 - "While none of the 35 benign prostates and 11 foci of adenosis expressed D-galactose-beta-[1-->3]-N-acetyl-D-galactosamine (100% specificity), 62 (95.4% sensitivity) of 65 adenocarcinomas variably expressed the marker. "
5.	Breast Neoplasms (Breast Cancer) 11/01/2008 - "In this study, the expression profile of two glycosyltranferases, UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) and alpha6-sialyl-transferase-I (ST6GalNAc-I) was assessed, in a cohort of women with breast cancer. " 02/01/2014 - "Here, we report the critical role of β1,3-N-acetylgalactosaminyltransferase II (B3GALNT2), which transfers N-acetylgalactosamine (GalNAc) in a β1,3 linkage to N-acetylglucosamine, in the growth of breast cancer cells. " 03/01/2006 - "UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker." 07/01/2003 - "Whether the expression level of the disaccharide group is affected upon malignant transformation was examined in human breast cancer specimens using Wistaria floribunda agglutinin (WFA) which interacts with oligosaccharides with N-acetylgalactosamine at their termini. " 09/15/2006 - "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (ppGalNAc-T6) mRNA as a potential new marker for detection of bone marrow-disseminated breast cancer cells."

Related Drugs and Biologics

1.	Galactose (Galactopyranose)
2.	Glycoconjugates
3.	Acetylglucosamine
4.	Glycoproteins (Glycoprotein)
5.	N-Acetylneuraminic Acid (Sialic Acid)
6.	Mannose (D-Mannose)
7.	Lectins
8.	Uridine Diphosphate (UDP)
9.	Fucose
10.	Carbohydrates

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Radioimmunotherapy
3.	Immunotherapy
4.	Homologous Transplantation (Allograft)
5.	Heterologous Transplantation (Xenotransplantation)