HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Acetylcarnitine (Alcar)

Subscribe to New Research on Acetylcarnitine

An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Also Known As:

Alcar; Acetyl-L-Carnitine; Carnitine, Acetyl; Acetylcarnitine, (R)-Isomer; Branigen; Glaxo Brand of Acetyl L-Carnitine; Levocarnitine Acetyl; Sigma-Tau brand of Acetyl L-Carnitine; Acetyl L Carnitine; Glaxo Brand of Acetyl L Carnitine; Sigma Tau brand of Acetyl L Carnitine; Acetyl Carnitine; Medosan; 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, inner salt

Networked: 345 relevant articles (59 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Quaternary Ammonium Compounds: 1159
    - Trimethyl Ammonium Compounds
      - Carnitine: 2673
        Acetylcarnitine: 345
        acetylcarnitine arginyl amide: 2
        3-acetylaminocarnitine
        bromoacetylcarnitine
        hemiacetylcarnitinium
        S-acetylthiocarnitine
        undecanoylcarnitine

Experts

1.	Calvani, Menotti: 11 articles (01/2009 - 12/2002)
2.	Nicolai, Raffaella: 8 articles (10/2013 - 12/2002)
3.	Malaguarnera, Mariano: 7 articles (05/2014 - 12/2006)
4.	Vacante, Marco: 7 articles (05/2014 - 03/2008)
5.	Malaguarnera, Michele: 6 articles (05/2014 - 03/2008)
6.	Wiberg, Mikael: 6 articles (01/2012 - 07/2002)
7.	Rampello, Liborio: 6 articles (12/2011 - 12/2006)
8.	Calvani, M: 6 articles (08/2007 - 01/2000)
9.	Ghelardini, Carla: 5 articles (06/2014 - 12/2002)
10.	Koverech, Aleardo: 5 articles (10/2013 - 09/2005)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 09/01/2002 - "Clinical trials of acetyl-l-carnitine indicate that it is well-tolerated and may be effective in younger Alzheimer's disease patients and may be an effective adjuvant treatment. " 06/01/2004 - "Acetyl-L-carnitine (ALC), a naturally occurring endogenous compound, has been shown to improve the cognitive performance of patients with senile dementia Alzheimer's type, and to be involved in cholinergic neurotransmission. " 09/01/2002 - "Augmentation of brain levels of acetyl-l-carnitine, an endogenous molecule, may help to reverse membrane phospholipid changes in Alzheimer's disease. " 01/01/1994 - "This suggests an explanation of the positive results obtained with ALCAR in the treatment of Alzheimer's disease." 11/01/1991 - "In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. "
2.	Pain (Aches) 05/01/2007 - "There was no statistically significant difference in changes in VAS over 14 days between groups for the intent-to-treat (ITT) population, but for the efficacy-evaluable (EE) population ALCAR treatment produced a significantly greater reduction in pain compared with placebo (P=0.022). " 01/01/2009 - "This study was designed to determine the short-term effect of acetyl-l-carnitine (ALC) on symptoms of withdrawal in opiate-dependent subjects and animals and, in particular, on pain, given the efficacy of ALC in other typologies of pain. " 02/17/2010 - "Aimed to explore the link between pain and neuroregeneration, the effect of ALCAR treatment (100 mg kg(-1) i.p. " 05/01/2007 - "ALCAR, administered twice a day intramuscularly to HIV-1-infected patients with symptomatic ATN, significantly reduced weekly mean pain ratings on the VAS compared with placebo. " 06/13/2014 - "Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis."
3.	Fatigue 05/01/2014 - "In subjects treated with Acetyl-L-Carnitine supplementation we observed increased daily activity and reduced presenteeism and fatigue. " 06/01/2013 - "Acetyl-L-carnitine treatment decreases the severity of mental and physical fatigue, depression cognitive impairment and improves health-related quality of life. " 03/01/2008 - "To determine the efficacy, tolerability and impact on the fatigue, as well as on cognitive and functional status of elderly subjects with acetyl L-carnitine (ALC), 96 aged subjects (>70 years, range 71-88) were investigated (50 females and 46 males; mean age 76.2+/-7.6 and 78.4+/-6.4 years, respectively). " 03/01/2008 - "Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue." 06/01/2003 - "The fatigue sensation is somehow related to hypofunction of the glutamatergic system through reduced uptake of acetyl-carnitine in the discrete brain regions. "
4.	Dementia (Dementias) 01/01/2003 - "The objective of this review is to establish whether Acetyl-l-carnitine is clinically effective in the treatment of people with dementia. " 01/01/1988 - "It is possible to affirm that the acetyl-L-carnitine treated patients showed statistically significant improvement in the behavioural performances (Blessed Dementia Scale p less than 0.02; Stuard Hospital Geriatric Rating Scale p less than 0.01), in the memory tests (Rey short-term p less than 0.02; Rey long-term p less than 0.05; Corsi p less than 0.05), in the attention test (Barrage test p less than 0.01) and in the Verbal Fluency test p less than 0.01)." 01/01/1990 - "Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia." 01/01/1989 - "Single-photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of L-acetylcarnitine." 01/01/2003 - "Acetyl-L-carnitine for dementia."
5.	Anoxia (Hypoxia) 04/01/2012 - "Becasue mitochondrial biogenesis could be a possible mechanism for ALCAR-induced improvement in bioenergetics in neurons, the present study aimed at exploring signaling pathways of ALCAR-induced neuroprotection in hypoxia and possible occurrence of mitochondrial biogenesis. " 06/30/2009 - "The results displayed reference memory impairment in Sprague-Dawley rats exposed to hypobaric hypoxia (7620 m) for 14 consecutive days which however improved on administration of ALCAR during hypoxic exposure. " 06/30/2009 - "The present study therefore reveals the therapeutic potential of ALCAR under conditions of hypobaric hypoxia and elucidates a novel mechanism of action of the drug." 04/01/2012 - "Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis." 09/10/2007 - "These results suggested that supplementation with acetyl-L-carnitine improves spatial working memory deficits reduces oxidative stress and inhibits apoptotic cascade induced by hypoxia."

Related Drugs and Biologics

1.	Acetylcarnitine (Alcar)
2.	Carnitine (L-Carnitine)
3.	Folic Acid (Vitamin M)
4.	Cysteine (L-Cysteine)
5.	Amantadine (Aman)
6.	Vitamins
7.	Methionine (L-Methionine)
8.	Ammonia
9.	Acetylcysteine (Siran)
10.	alpha-Tocopherol

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Drug Therapy (Chemotherapy)
4.	Ligation
5.	Axotomy