Acetolactate Synthase

A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.

Also Known As:

Acetohydroxyacid Synthetase I; Acetoxyhydroxyacid Synthase III; Acid Synthase, Acetohydroxy; Acid Synthetase, Acetohydroxy; Synthase III, Acetoxyhydroxyacid; Synthase, Acetohydroxy Acid; Synthase, Acetolactate; Synthetase I, Acetohydroxyacid; Synthetase, Acetohydroxy Acid; Synthetase, Acetolactate; Acetohydroxy Acid Synthase; Acetohydroxy Acid Synthetase; Acetolactate Synthetase; Acetolactate pyruvate-lyase (carboxylating)

Networked: 18 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Iwakami, Satoshi: 2 articles (05/2020 - 07/2012)
2.	Uchino, Akira: 2 articles (05/2020 - 07/2012)
3.	Causse, Romain: 2 articles (01/2016 - 05/2015)
4.	Délye, Christophe: 2 articles (01/2016 - 05/2015)
5.	Michel, Séverine: 2 articles (01/2016 - 05/2015)
6.	Cheng, Yufeng: 2 articles (03/2015 - 01/2013)
7.	Cui, Jianmin: 2 articles (03/2015 - 01/2013)
8.	Hu, Shengwu: 2 articles (03/2015 - 01/2013)
9.	Li, Zhanjie: 2 articles (03/2015 - 01/2013)
10.	Zhao, Huixian: 2 articles (03/2015 - 01/2013)

Related Diseases

1.	Dehydration (Water Stress) 01/01/2023 - "The water stress conditions in experiment 1 compromised the efficacy of acetolactate synthase enzyme (ALS) inhibitor herbicides in the control of sourgrass. "
2.	Male Infertility (Male Sterility) 12/07/2015 - "Tribenuron-Methyl Induces Male Sterility through Anther-Specific Inhibition of Acetolactate Synthase Leading to Autophagic Cell Death." 01/01/2017 - "Background: Acetolactate synthase (ALS)-inhibiting herbicides amidosulfuron (Hoestar) is an efficient gametocide that can induce male sterility in rapeseed (Brassica napus L.). " 01/01/2013 - "Monosulphuron ester sodium (MES), a new acetolactate synthase-inhibitor herbicide belonging to the sulphonylurea family, has been developed as an effective CHA to induce male sterility in rapeseed (Brassica napus L.). " 03/17/2015 - "We previously discovered that monosulfuron ester sodium (MES), an acetolactate synthase (ALS) inhibitor of the herbicide sulfonylurea family, can induce rapeseed (Brassica napus L.) male sterility at approximately 1% concentration required for its herbicidal activity. "
3.	Juvenile Amyotrophic Lateral Sclerosis 2 11/22/2023 - "Pro-197-Thr and Trp-574-Leu mutations in acetolactate synthase (ALS) 1 and ALS2 of the resistant population drove reduced sensitivity of penoxsulam to the target-site ALS, the primary resistance mechanisms. " 12/01/2014 - "Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean." 09/01/2013 - "Schoenoplectus juncoides, a noxious weed for paddy rice, is known to become resistant to sulfonylurea (SU) herbicides by a target-site mutation in either of the two acetolactate synthase (ALS) genes (ALS1 and ALS2). " 10/01/2015 - "DNA vectors expressing maize codon-optimized Streptococcus pyogenes Cas9 endonuclease and single guide RNAs were cointroduced with or without DNA repair templates into maize immature embryos by biolistic transformation targeting five different genomic regions: upstream of the liguleless1 (LIG1) gene, male fertility genes (Ms26 and Ms45), and acetolactate synthase (ALS) genes (ALS1 and ALS2). "
4.	Starvation 03/01/2010 - "Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin." 06/01/1985 - "Starvation for leucine or valine, but not for any of the other nine amino acids, resulted in high levels of acetohydroxy acid synthase I. These results are discussed in terms of a report (C.A. " 06/01/1985 - "Starvation for ilvB operon leader amino acids other than leucine or valine does not increase acetohydroxy acid synthase activity in Escherichia coli." 03/01/1998 - "The Trp pathway enzymes and cytosolic glutamine synthetase were induced under all of the amino acid starvation test conditions, whereas methionine synthase and acetolactate synthase were not. "
5.	Tetraploidy 05/01/2020 - "Characterization of the acetolactate synthase gene family in sensitive and resistant biotypes of two tetraploid Monochoria weeds, M. " 01/01/2016 - "Following control failure by herbicides inhibiting acetolactate synthase (ALS) in French wheat fields and vineyards, we aimed to confirm resistance evolution and investigate the evolutionary origin and spread of resistance in the tetraploid species Senecio vulgaris (common groundsel), a widespread, highly mobile weed. "

Related Drugs and Biologics

1.	Herbicides
2.	Enzymes
3.	Amino Acids
4.	Sodium
5.	Esters
6.	DNA (Deoxyribonucleic Acid)
7.	Codon (Codons)
8.	Sirolimus (Rapamycin)
9.	Valine (L-Valine)
10.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)