Acetate Kinase

An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Burne, Robert A: 2 articles (01/2017 - 08/2015)
2.	Kim, Jeong Nam: 2 articles (01/2017 - 08/2015)
3.	Aepfelbacher, Martin: 1 article (01/2021)
4.	Alawi, Malik: 1 article (01/2021)
5.	Baig, Sharmin: 1 article (01/2021)
6.	Both, Anna: 1 article (01/2021)
7.	Büttner, Henning: 1 article (01/2021)
8.	Christner, Martin: 1 article (01/2021)
9.	Citak, Mustafa: 1 article (01/2021)
10.	Failla, Antonio Virgilio: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2021 - "Importantly, subpopulations carrying IS insertions in agrC, mutations in the acetate kinase (AckA) and deletions in the SCCmec element emerged in several infections. " 03/19/2015 - "The basidiomycete Cryptococcus neoformans, an invasive opportunistic pathogen of the central nervous system, is the most frequent cause of fungal meningitis worldwide resulting in more than 625,000 deaths per year worldwide. Although electroporation has been developed for the transformation of plasmids in Cryptococcus, only biolistic delivery provides an effective means to transform linear DNA that can be integrated into the genome by homologous recombination.  Acetate has been shown to be a major fermentation product during cryptococcal infection, but the significance of this is not yet known. A bacterial pathway composed of the enzymes xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (Xfp) and acetate kinase (Ack) is one of three potential pathways for acetate production in C. "
2.	Dental Caries (Decay, Dental) 01/01/2017 - "In the dental caries pathogen Streptococcus mutans, phosphotransacetylase (Pta) and acetate kinase (Ack) convert pyruvate into acetate with the concomitant generation of ATP. " 08/01/2015 - "In the dental caries pathogen Streptococcus mutans, phosphotransacetylase (Pta) catalyzes the conversion of acetyl coenzyme A (acetyl-CoA) to acetyl phosphate (AcP), which can be converted to acetate by acetate kinase (Ack), with the concomitant generation of ATP. "
3.	Fungal Meningitis 03/19/2015 - "The basidiomycete Cryptococcus neoformans, an invasive opportunistic pathogen of the central nervous system, is the most frequent cause of fungal meningitis worldwide resulting in more than 625,000 deaths per year worldwide. Although electroporation has been developed for the transformation of plasmids in Cryptococcus, only biolistic delivery provides an effective means to transform linear DNA that can be integrated into the genome by homologous recombination.  Acetate has been shown to be a major fermentation product during cryptococcal infection, but the significance of this is not yet known. A bacterial pathway composed of the enzymes xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (Xfp) and acetate kinase (Ack) is one of three potential pathways for acetate production in C. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/2014 - "The described results of acetate kinase, an important enzyme in the process of organic compounds oxidation and dissimilatory sulfate reduction would be perspective and useful for clarification of the etiological role of these bacteria in the development of inflammatory bowel diseases in humans and animals. "
5.	Tuberculosis (Tuberculoses) 10/26/2022 - "tuberculosis cells grown on acetate, there is considerable cell-to-cell variation in the level of mRNA coding for AckA, the acetate kinase. "

Related Drugs and Biologics

1.	Acetates (Acetic Acid Esters)
2.	Adenosine Triphosphate (ATP)
3.	Phosphate Acetyltransferase
4.	Enzymes
5.	acetyl phosphate
6.	Pyruvic Acid (Pyruvate)
7.	Xylulose
8.	Sulfates (Sulfates, Inorganic)
9.	Messenger RNA (mRNA)
10.	Phosphates (Orthophosphate)