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Acenocoumarol

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A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

Also Known As:

Alliance Brand of Acenocoumarol; Ciba-Geigy Brand of Acenocoumarol; Mini-Sintrom; Novartis Brand of Acenocoumarol; Sinkumar; Sinthrome; Sintrom; Syncoumar; Syncumar; Synthrom; Acenocoumarol Alliance Brand; Acenocoumarol Ciba-Geigy Brand; Acenocoumarol Novartis Brand; Ciba Geigy Brand of Acenocoumarol; Mini Sintrom; MiniSintrom; Acenocoumarin; Nicoumalone; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-

Networked: 280 relevant articles (13 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Pyrans: 5
  - Benzopyrans: 11
    - Coumarins: 240
      - 4-Hydroxycoumarins: 2
        Acenocoumarol: 280
        N-(4-(1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-3-oxobutyl)phenyl)acetamide
- 2-Ring Heterocyclic Compounds
  - Benzopyrans: 11
    - Coumarins: 240
      - 4-Hydroxycoumarins: 2
        Acenocoumarol: 280
        N-(4-(1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-3-oxobutyl)phenyl)acetamide

Experts

1.	Lip, Gregory Y H: 6 articles (11/2015 - 07/2011)
2.	Lane, Deirdre A: 4 articles (09/2015 - 07/2011)
3.	de Boer, Anthonius: 4 articles (04/2014 - 01/2008)
4.	Kropacheva, E S: 4 articles (01/2011 - 01/2004)
5.	Panchenko, E P: 4 articles (01/2011 - 01/2004)
6.	Büller, Harry R: 3 articles (09/2015 - 10/2005)
7.	Rosendaal, Frits R: 3 articles (12/2013 - 06/2002)
8.	Bykova, E S: 3 articles (01/2007 - 01/2004)
9.	Titaeva, E V: 3 articles (01/2007 - 01/2004)
10.	Dobrovol'skiĭ, A B: 3 articles (01/2007 - 01/2004)

Related Diseases

1.	Venous Thrombosis (Deep-Vein Thrombosis) 05/01/1998 - "A 69-year-old man developed cholestatic liver enzyme disturbances three and a half weeks after starting treatment with acenocoumarol because of a deep venous thrombosis in his leg. " 01/01/1998 - "Pharmacokinetic and pharmacodynamic variations of acenocoumarol orally administrated either once or twice daily in patients with deep venous thrombosis." 01/01/1993 - "We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. " 08/01/2008 - "The patient had been receiving acenocoumarol 4 mg/d for 10 years for episodes of atrial fibrillation and recurrent deep venous thrombosis. " 03/01/2004 - "We present the case of an obese woman that developed an extensive cutaneous necrosis while receiving acenocoumarol for a deep venous thrombosis. "
2.	Stroke (Strokes) 11/01/2001 - "Even though no clinical benefit (pertaining to the frequency of painful crises) was detected in this pilot study, the value of low adjusted-dose acenocoumarol for preventing specific events (such as strokes) and as a long-term treatment of sickle cell patients should be subject of further study." 01/01/2004 - "Ischemic strokes, episodes of systemic thromboembolism and hemorrhagic complications were registered during 3 years of treatment with acenocoumarol (target INR 2.0-3.0). " 02/25/2014 - "Triflusal plus acenocoumarol is likely more effective than acenocoumarol alone in reducing stroke risk. " 01/01/2015 - "The rates of thromboembolic events were similar under dabigatran and acenocoumarol treatment: strokes, 0.094 vs. 0 /patient-year, p=0.36; systemic embolism, no event in either group; and device thrombosis, 0.053 vs. 0.258 events/patient-year, p=0.19, respectively. " 07/01/2008 - "We report a case of 66-years-old man with prosthetic aortic valve after three ischemic strokes treated with acenocoumarol who was admitted to hospital with vertigo and motoric aphasia. "
3.	Atrial Fibrillation 01/01/2007 - "The aim of the study was to assess knowledge of oral anticoagulation in a group of patients with atrial fibrillation (AF) treated with acenocoumarol and to determine the relationship between knowledge and INR value. " 11/27/2015 - "To assess effects of the ABCB1 pilymorphisms on safety profile and dosing regimen of acenocoumarol in the patients with valvular atrial fibrillation. " 11/27/2015 - "ABCB1 polymorphism and acenocoumarol safety in patients with valvular atrial fibrillation." 11/01/2015 - "In a prospective "real-world" inception cohort of patients with atrial fibrillation initiating oral anticoagulation with acenocoumarol, we have validated the clinical value of the SAME-TT2R2 score for the identification of patients who would have poor-quality anticoagulation. " 09/01/2015 - "Low dose dabigatran versus uninterrupted acenocoumarol for peri-procedural anticoagulation in atrial fibrillation catheter ablation."
4.	Pulmonary Embolism 02/01/2015 - "Despite the use of high doses of acenocoumarol (114 mg/week) for the treatment of recurrent pulmonary embolism, the International Normalized Ratio was below the therapeutic target. " 01/01/1992 - "Two years after the episode of pulmonary embolism, the patient, still taking acenocoumarol, remained free from any sequela. " 09/01/2000 - "She was treated by acenocoumarol for atrial fibrillation and pulmonary embolism. " 01/01/1994 - "The neutropenia began just after the treatment of pulmonary embolism by acenocoumarol. " 03/01/2007 - "This study aimed to determine whether a weight-adjusted dose of subcutaneous enoxaparin is as effective and safe as oral acenocoumarol for the secondary prophylaxis of pulmonary embolism. "
5.	Thrombosis (Thrombus) 01/01/2004 - "The use of acenocoumarol for 12 months resulted in significant reduction of frequency of left auricular thrombosis. " 12/01/2011 - "There were 2 maternal deaths due to acute mitral valvular thrombosis while on acenocoumarol in the second trimester. " 12/01/2009 - "He was on acenocoumarol treatment because of portal, splenic and mesenteric vein thrombosis (PSMVT) 3 months before, with admission international normalized ratio (INR):1.6. " 01/01/2004 - "Clinical-instrumental predictors of presence of left auricular thrombosis and its dynamics during therapy with acenocoumarol were also elucidated." 10/02/1993 - "[Initial heparinization necessary in patients with thrombosis of the leg; comparison with acenocoumarol treatment]."

Related Drugs and Biologics

1.	Warfarin (Coumadin)
2.	Phenprocoumon (Liquamar)
3.	Vitamin K
4.	Enoxaparin (Lovenox)
5.	Aspirin (Acetylsalicylic Acid)
6.	coumarin
7.	glucuronyl glucosamine glycan sulfate (Vessel)
8.	Ticlopidine (Ticlid)
9.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)
10.	Losartan (Cozaar)

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