Acedapsone (DADDS)

Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

Also Known As:

DADDS; 4',4'''-Sulfonylbis(acetanilide); 4,4'-Diacetyldiaminodiphenylsulfone; Hansolar; Rodilone; Sulfadiamine; 4,4' Diacetyldiaminodiphenylsulfone; Acetyldiphenazonum; Diacetyldapsone; Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis-

Networked: 43 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - Dapsone: 2368
      - Acedapsone: 43

Experts

1.	Rodin, Gary: 4 articles (01/2021 - 10/2011)
2.	Hales, Sarah: 3 articles (01/2021 - 10/2011)
3.	Zimmermann, Camilla: 2 articles (01/2021 - 10/2011)
4.	Engelmann, Dorit: 2 articles (11/2019 - 10/2016)
5.	Scheffold, Katharina: 2 articles (11/2019 - 10/2016)
6.	Schulz-Kindermann, Frank: 2 articles (11/2019 - 10/2016)
7.	Lo, Chris: 2 articles (10/2016 - 01/2015)
8.	Rydall, Anne: 2 articles (01/2015 - 10/2011)
9.	Bravo, Paulina: 1 article (01/2021)
10.	Echeverria, Claudia Acevedo: 1 article (01/2021)

Related Diseases

1.	Leprosy (Hansen's Disease) 10/01/1993 - "At the time of study, 29 of the Aborigines were receiving acedapsone intramuscularly for control of leprosy. " 05/01/1979 - "Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia." 01/01/1972 - "Acedapsone in leprosy treatment: trial in 68 active cases in Micronesia." 04/01/1986 - "Limited duration acedapsone prophylaxis in leprosy." 01/01/1977 - "Acedapsone treatment of leprosy patients: response versus drug disposition."
2.	Neoplasms (Cancer) 12/07/2022 - "The aim of this study was to examine the psychometric properties of the Italian version of the Death and Dying Distress Scale (DADDS-IT) in a sample of patients with advanced cancer. " 10/01/2011 - "In this study, we introduce the Death and Dying Distress Scale (DADDS), a new, brief measure we have developed to assess death-related anxiety in advanced cancer and other palliative populations. " 01/01/2021 - "The objective of this project is to validate the Death and Dying Distress Scale in Spanish (DADDS-Sp) for screening anxiety about death and evaluating psychometric properties for people with advanced cancer. " 01/01/2021 - "Validation of the Death and Dying Distress Scale (DADDS-Sp) in a population with advanced cancer in Chile." 01/01/2021 - "Conclusion: DADDS-C is a valid tool for measuring death anxiety in Chinese patients with advanced cancer. "
3.	Lepromatous Leprosy 06/01/1975 - "A preliminary report on a therapeutic trial with acedapsone in lepromatous leprosy." 07/01/1979 - "Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy." 07/01/1976 - "This presentation reports the results of a short clinical trial with DADDS in 23 patients of lepromatous leprosy. " 07/01/1976 - "Clinical trial of DADDS in lepromatous leprosy." 03/01/1986 - "The number of Mycobacterium leprae in the pretreatment biopsy-specimen does not determine the rate of response of patients with lepromatous leprosy to chemotherapy with acedapsone."
4.	Multibacillary Leprosy 05/01/1989 - "[Bacteriologic study in patients with multibacillary leprosy treated with rifampicin and acedapsone]."
5.	Conduct Disorder (Conduct Disorders) 01/01/2016 - "Children with conduct problems and callous unemotional traits (CPCU) seem to show a decreased response to behavioral treatment (Hawes, Price, & Dadds, 2014). " 07/01/2014 - "Commentary: Improving treatment for youth with callous-unemotional traits through the intersection of basic and applied science--reflections on Dadds et al. (2014)." 03/01/2011 - "Examining eye contact in youth with conduct problems and callous unemotional traits-reflections on Dadds et al. (2011)."

Related Drugs and Biologics

1.	Dapsone
2.	Rifampin (Rifampicin)
3.	monoacetyldapsone
4.	Acedapsone (DADDS)
5.	diformyl dapsone (DFD)
6.	Therapeutic Uses
7.	Clavulanic Acid (Potassium Clavulanate)
8.	Itraconazole (Sporanox)
9.	Clarithromycin (Biaxin)
10.	Mefloquine (Lariam)

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics
3.	Injections
4.	Drug Therapy (Chemotherapy)