Abrin

A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.

Also Known As:

Networked: 96 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saxena, Nandita: 5 articles (07/2022 - 09/2013)
2.	Gal, Yoav: 3 articles (04/2020 - 09/2015)
3.	Mazor, Ohad: 3 articles (04/2020 - 09/2015)
4.	Kang, Lin: 3 articles (01/2015 - 04/2004)
5.	Ramnath, V: 3 articles (06/2009 - 01/2002)
6.	Nagar, D P: 2 articles (07/2022 - 06/2017)
7.	Xu, Hua: 2 articles (01/2022 - 01/2022)
8.	Alcalay, Ron: 2 articles (04/2020 - 01/2018)
9.	Falach, Reut: 2 articles (04/2020 - 09/2015)
10.	Kronman, Chanoch: 2 articles (04/2020 - 09/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1975 - "[Study on anti-cancer activity of abrin: effects of abrin on leukocyte and lymphocyte in peripheral blood of rats (author's transl)]." 05/01/2016 - "It was found that abrin P2 exhibited cytotoxicity toward 12 different human cancer cell lines. " 06/01/2009 - "Results suggested that abrin effectively induced apoptotic changes in the tumor cells that led to cellular death." 01/01/2006 - "Antibody dependent cellular cytotoxicity was enhanced in the abrin treated tumor-bearing group on the ninth day (44% cell lysis). " 01/01/2006 - "Natural killer cell activity was enhanced significantly by abrin in both the normal (49.8% cell lysis on day 9) and the tumor-bearing group (51.7% cell lysis on day 9), and it was found to be earlier than the control. "
2.	Lymphoma (Lymphomas) 04/01/2009 - "The present study was designed to evaluate the in vivo therapeutic effectiveness of abrin-derived peptide (ABP) fraction in Dalton's lymphoma (DL) mice model. " 01/01/2002 - "Both intralesional and intraperiloneal (i.p.) administration of abrin was effective in reducing solid tumour mass development induced by Dalton's Lymphoma Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cells. " 07/01/2009 - "In our previous study, Abrus abrin derived peptide fraction (ABP) with molecular weight in range of 600-1500Da was shown to have potent antitumor activity in Dalton's lymphoma (DL) tumor bearing mice. " 06/01/2009 - "The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated. " 06/01/2009 - "Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin."
3.	Inflammation (Inflammations) 07/01/2022 - "Abrin intoxication resulted in hepatotoxicity, oxidative stress, inflammation, altered histopathology and increased Fas pathway signaling. " 07/01/2022 - "Parameters related to liver functions, oxidative stress, inflammation, Fas pathway and histopathology were evaluated in the liver of BALB/c mice after abrin exposure. " 09/01/2019 - "Further, at higher doses of abrin, intensity of oxidative stress, inflammation and liver toxicity are more pronounced which may have been maintained by the self-sustaining loop of toxicity leading to death of the animals." 07/01/2022 - "Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway." 06/01/2017 - "In this study we examined the in vivo nephrotoxicity potential of abrin toxin in terms of oxidative stress, inflammation, histopathological changes and biomarkers of kidney injury. "
4.	Ascites 01/01/2002 - "Both intralesional and intraperiloneal (i.p.) administration of abrin was effective in reducing solid tumour mass development induced by Dalton's Lymphoma Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cells. " 06/01/2009 - "The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated. " 06/01/2009 - "Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin." 04/01/2009 - "Inhibitory effect of Abrus abrin-derived peptide fraction against Dalton's lymphoma ascites model." 11/15/1975 - "The mechanism of protein synthesis inhibition by the toxic lectins, abrin and ricin, has been studied in crude and in purified cell-free systems from rabbit reticulocytes and Krebs II ascites cells. "
5.	Carcinoma (Carcinomatosis) 01/01/2002 - "Both intralesional and intraperiloneal (i.p.) administration of abrin was effective in reducing solid tumour mass development induced by Dalton's Lymphoma Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cells. " 01/01/1984 - "Delivery of ricin and abrin A-chains to human carcinoma cells in culture following covalent linkage to monoclonal antibody LICR-LOND-Fib 75." 01/01/1984 - "Similar combinations of abrin or ricin with cisplatin also produced significant additive or synergistic increases in survival times of mice bearing cell line B of L1210 leukemia or Ehrlich ascites carcinoma. " 01/01/1984 - "Abrin, ricin, and cisplatin produced significant increases in survival times of mice inoculated with 10(6) Ehrlich ascites carcinoma or L1210 leukemia cells 24 hours prior to treatment. "

Related Drugs and Biologics

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2.	Ricin
3.	Messenger RNA (mRNA)
4.	Silybin (Lagosa)
5.	Peptides (Polypeptides)
6.	Vinblastine (Vinblastine Sulfate)
7.	Lomustine (CCNU)
8.	Dacarbazine (DIC)
9.	Procarbazine (Matulane)
10.	Cytotoxins (Cytolysins)

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Adjuvant Chemotherapy
5.	Immunotherapy