Missed Abortion

The retention in the UTERUS of a dead FETUS two months or more after its DEATH.

Also Known As:

Abortion, Missed; Abortions, Missed; Missed Abortions

Networked: 424 relevant articles (28 outcomes, 53 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Pregnancy Complications: 2961
    - Spontaneous Abortion: 8599
      - Missed Abortion: 424

Related Diseases

1.	Fetal Death
2.	Spontaneous Abortion (Miscarriage)
3.	Ectopic Pregnancy
4.	Missed Abortion
5.	Hydatidiform Mole (Molar Pregnancy)

Experts

1.	Daponte, Alexandros: 5 articles (01/2013 - 09/2011)
2.	Messinis, Ioannis E: 5 articles (01/2013 - 09/2011)
3.	Pournaras, Spyros: 5 articles (01/2013 - 09/2011)
4.	Haller, Herman: 4 articles (09/2018 - 01/2011)
5.	Laskarin, Gordana: 4 articles (09/2018 - 01/2011)
6.	Rukavina, Daniel: 4 articles (09/2018 - 01/2011)
7.	Fang, Yan: 3 articles (05/2021 - 05/2011)
8.	Gulic, Tamara: 3 articles (09/2018 - 07/2013)
9.	Ozbilgin, Kemal: 3 articles (03/2017 - 02/2015)
10.	Vatansever, Seda: 3 articles (03/2017 - 02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Missed Abortion:

1.	Misoprostol (Cytotec)FDA LinkGeneric 11/01/2002 - "Vaginal misoprostol 0.4-0.6 mg is effective in most patients with missed abortion. " 10/01/2000 - "The described regimen of vaginal misoprostol is safe and reasonably effective in inducing complete evacuation in missed abortions. " 10/01/2000 - "To evaluate the efficacy of a regimen of vaginal misoprostol in causing the complete expulsion of first-trimester missed abortions, or alternatively dilating the cervix for surgical evacuation. " 04/01/2019 - "Sublingual misoprostol is more effective than vaginal misoprostol in completing first trimester missed abortion, with a shorter induction-expulsion time. " 05/01/2016 - "Vaginal misoprostol is more effective than oral misoprostol for first trimester missed abortion."
2.	Dinoprostone (PGE2)FDA Link 12/28/2008 - "Comparison between Intravenous and Intramuscular Administration of Prostaglandin E2 on Management of Missed Abortion." 05/01/1994 - "32 consecutive patients with ultrasonographic diagnosis of missed abortion from 6th-13th week of gestation were randomly allocated to either single (group A) or repeated, 2 h apart (group B), intracervical application of PGE2 gel. " 05/01/1994 - "Pre-operative cervical preparation before first trimester missed abortion: a randomized controlled comparison between single or double intracervical administration of PGE2 gel." 01/01/1980 - "To terminate pregnancy 15 women with an established diagnosis of missed abortion or intrauterine dead fetuses were treated with 1.0 mg Prostaglandin E2 in viscous gel applied as a single intracervical dose. " 01/01/1980 - "Termination of pregnancy in patients with missed abortion and intrauterine dead fetuses by a single intracervical application of prostaglandin E2 in viscous gel."
3.	Mifepristone (RU 486)FDA Link 08/28/1993 - "Of the 1151 women with known outcome, 95.5% had a complete abortion (364 (93.8%) of those given 200 mg mifepristone, 368 (94.1%) of those given 400 mg, and 367 (94.3%) of those given 600 mg), 3.7% had an incomplete abortion (14 (3.6%), 15 (3.8%), and 14 (3.6%)), 0.3% had a missed abortion (three (0.8%), one (0.3%), and none), and 0.4% had a continuing live pregnancy (two (0.5%), two (0.5%), and one (0.3%)). " 01/01/2021 - "The aim of this study was to investigate the effect of mifepristone with misoprostol treatment on the efficacy of patients with missed abortion (MA) and the safety of this drug regimen. " 11/01/2002 - "To compare the efficacy of two different medical treatment regimens: mifepristone 600 mg orally + misoprostol 0.4 mg vaginally (Mf + Ms) or misoprostol 0.4 mg vaginally (Ms) with conventional surgical evacuation (SE) in women with missed abortion. " 01/01/2023 - "Retracted: Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion." 01/01/2021 - "Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion."
4.	DinoprostIBA 01/01/1988 - " PGF2 alpha administered by the extra-amniotic route is effective for mid-trimester missed abortion, by using a sustained, pre-set release to achieve therapeutic levels. " 01/01/1988 - "Prostaglandin (F2 alpha) and missed abortion." 01/01/1986 - "Prostaglandin (F2 alpha) in missed abortion. " 04/01/1985 - "[Transcervical intra-amniotic induction with PgF2 alpha in missed abortion and labor in the 3d trimester of pregnancy with dead fetus. " 12/01/1982 - " 15(S) 15 methyl PGF2alpha has a high degree of efficacy in the management of missed abortion."
5.	ProstaglandinsIBA 01/01/1986 - "Prostaglandin F2-alpha was administered by the intravenous, extra-amniotic and intramuscular routes in three comparable groups of patients with missed abortion, during a randomized study. " 10/15/1982 - "144 patients aged 18-41 were observed to study a new method of cervical perfusion of prostaglandins (PGs) to induce labor and missed abortion. " 12/28/2008 - "In a randomized clinical trail, 50 women with confirmed missed abortion received 250-500 Î¼g prostaglandins E2 either intravenously or intramuscularly. " 10/01/1993 - "A 31-year-old Hispanic woman underwent three prostaglandin inductions for a second-trimester missed abortion. " 01/01/1988 - "Prostaglandins offer an easy safe method for management of missed abortions. "
6.	Fibrinogen (Factor I)FDA Link 01/01/2011 - "In addition, fibrinogen was decreased in the missed abortion group. " 10/01/1965 - "[Drop of the fibrinogen level in missed abortion]." 10/01/1992 - "We present a study of fibrinogen levels in 133 patients who were prone to develop disseminated intravascular coagulation as a result of an underlying complication of pregnancy such as abruptio placentae, pregnancy-induced hypertension, missed abortion, septic abortion, intrauterine fetal death, vesicular mole and amniotic fluid embolism. " 01/01/2011 - "Troponin I, C-reactive protein and fibrinogen levels in missed abortions." 12/01/2018 - "We evaluated the clinical values of 4 serum indices and their relationship to missed abortion: gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH), adenosine deaminase (ADA), and fibrinogen (FIB).The serum levels of GGT, ADA, and FIB showed statistically significant differences comparing women who experienced missed abortion with women who had normal pregnancies (controls). "
7.	gemeprostIBA 01/01/1987 - " Gemeprost was most effective in the missed abortion group (8/10 cases of complete abortion compared to 4/10 cases of complete abortion in the normal pregnancies). " 01/01/1987 - " It is concluded that gemeprost used after laminaria is convenient, safe, and effective for the termination of 2nd-trimester pregnancy especially in cases of missed abortion." 01/01/1995 - "Gemeprost for first trimester missed abortion." 01/01/1987 - " This study examined the efficacy of gemeprost in 2nd-trimester missed abortion (10 women) and in normal pregnancies selected for legal abortion (10 women). " 01/01/1987 - " The total dose of gemeprost per mcg/kg of body weight was also less in the missed abortion group (mean of 26.1) than in the legal abortion group (36.4). "
8.	TabletsIBA 07/01/2007 - "The use of tablet misoprostol is effective for uterine evacuation in cases of missed abortion." 07/01/2007 - "A total of 30 patients were included in this study to evaluate the efficacy of tablet misoprostol for uterine evacuation in cases of missed abortion. " 08/01/2005 - "Labour was induced in 42 women with missed abortion at the Women's Health and Action Research Centre, Benin City, Nigeria with intermittent vaginal administration of 100 microg tablets of misoprostol every 6 h. " 01/01/2003 - "We used PGE(1) gel prepared from tablets and administered in the ambulatory form (group 1), the same PGE(1) gel administered in the labor room (group 2) and intravenously administered oxytocin in the labor room (group 3) for the induction of abortus in women complicated with intrauterine fetus death and missed abortion. "
9.	Adenosine DeaminaseIBA 07/01/2005 - "The aim of this study is to assess adenosine deaminase (ADA) activity in the serum and placenta of patients with missed abortions, anembryonic pregnancies, and voluntary abortions. " 07/01/2005 - "Adenosine deaminase activity in serum and placenta of patients with anembryonic pregnancies and missed abortions." 12/01/2018 - "We evaluated the clinical values of 4 serum indices and their relationship to missed abortion: gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH), adenosine deaminase (ADA), and fibrinogen (FIB).The serum levels of GGT, ADA, and FIB showed statistically significant differences comparing women who experienced missed abortion with women who had normal pregnancies (controls). "
10.	Oxytocin (Pitocin)FDA LinkGeneric 02/01/1981 - " Only 1.57% of women with regular pregnancy did not need oxytocin, versus 31.8% of women with missed abortion. " 08/15/1966 - "Management of missed abortion by highly concentrated intravenous oxytocin." 01/01/1963 - "[TREATMENT OF MISSED ABORTION BY CONTINUOUS PERFUSION OF WEAK DOSES SYNTOCINON]." 11/28/1962 - "THE USE OF HIGH CONCENTRATION PITOCIN INTRAVENOUS DRIPS IN THE MANAGEMENT OF MISSED ABORTION." 04/01/1959 - " It was concluded that the use of oxytocin drips is a reliable, rapid and safe method of managing missed abortion."

Therapies and Procedures

1.	Curettage 04/01/2012 - "Comparative histological study of uterine curettage specimens in missed abortion in women with spontaneous and induced pregnancy and progressing spontaneous pregnancy revealed similar changes in the endometrium and placental villi. " 07/14/2023 - "This was a retrospective cohort study including 148 women who underwent dilation and curettage for missed abortion. " 11/07/2022 - "Does ultrasound guidance during Dilation and Curettage for first trimester missed abortion reduce complication rates?" 05/30/2022 - "Human decidual stromal cells were isolated from the abortus tissue and collected by curettage from missed abortion patients and normal pregnant women at 6- to 12-week gestation, after informed consent. " 11/01/2021 - "Missed abortion can be treated with medication or aspiration curettage. "
2.	Intravaginal Administration 01/01/2020 - "Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study." 10/01/2016 - "Comparison Between Sublingual and Vaginal Administration of Misoprostol in Management of Missed Abortion." 03/01/1997 - "Vaginal administration of misoprostol to women with a missed abortion produced spontaneous expulsion of the pregnancy and reduced the need for surgical treatment." 10/01/2016 - "Sublingual administration of misoprostol is more effective than its vaginal administration in missed abortion management. " 10/01/2016 - "The aim of the present study is to compare between sublingual administration of misoprostol and vaginal administration in the management of missed abortion. "
3.	Sublingual Administration 04/01/2017 - "The followings were found to be independently associated with cervical dilatation in a linear regression analysis: sublingual administration, gestational age, missed abortion, and previous vaginal delivery. " 06/01/2010 - "To evaluate the efficacy of two routes of misoprostol administration (sublingual and vaginal) for the treatment of missed abortion. " 10/01/2016 - "Sublingual administration of misoprostol is more effective than its vaginal administration in missed abortion management. " 10/01/2016 - "The aim of the present study is to compare between sublingual administration of misoprostol and vaginal administration in the management of missed abortion. "
4.	Induced Labor 11/27/2023 - "Two patients developed missed abortions within 1 month of surgery, one underwent induction of labor due to a dead fetus at 24 weeks and 5 days of gestation, and the other patients did not develop adverse events after surgery. " 09/01/1962 - "Termination of missed abortion and the induction of labor in midtrimester pregnancy." 09/01/1978 - " In cases of induction of labor (e.g., intrauterine fetal death or missed abortion), PGs have a success rate of 85-98%, with minor side effects. " 01/01/1971 - " These include induction of labor at or near term, therapeutic termination of early pregnancy, and the treatment of missed abortion, missed labor, and hydatidiform mole. " 10/01/1982 - " Other areas in which PGs are routinely used or where their use is being developed include menstrual induction, preevacuation dilatation of the cervix in the 1st trimester, termination of pregnancy in missed abortion, intrauterine fetal death and other types of abnormal pregnancies, control of postpartum hemorrhage, treatment of postpartum or postsurgical urine retention, and ripening of the cervix prior to the induction of labor at term. "
5.	Legal Abortion (Legal Abortions) 01/01/1987 - " The mean induction-delivery interval was shorter (223 minutes) in the missed abortion group than in the legal abortion group (396 minutes), even though the mean number of laminaria tents used was smaller in the former group (3 versus 8). " 01/01/1982 - " 92.8% of the 291 patients treated were seeding legal abortion and 7.2% were treated for missed abortion. " 08/01/1977 - "The average period until abortion occurred in the missed abortion group was 8.2 hours (+/- 4.5 SD), and in the legal abortion group 16.4 hours (+/- 7.3 SD). " 08/01/1977 - "All 12 patients with missed abortion and 87% of the legal abortion patients aborted within 24 hours. " 08/01/1998 - "The outcome was ascertained for 780 (94%) of these 831 pregnancies: 547 (66%) births; 10 (1%) ectopic pregnancies; 94 (11%) spontaneous miscarriages; 5 (< 1%) missed abortions; 120 (14%) legal abortions; and 4 (< 1%) intrauterine deaths. "