Calcimycin (A23187)

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

Also Known As:

A23187; A-23187; Antibiotic A23187; A 23187; A23187, Antibiotic; 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-

Networked: 792 relevant articles (7 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Qi: 4 articles (10/2011 - 07/2007)
2.	Kuriyama, Isoko: 3 articles (06/2015 - 11/2012)
3.	Mizushina, Yoshiyuki: 3 articles (06/2015 - 11/2012)
4.	Jippo, Tomoko: 3 articles (06/2014 - 01/2012)
5.	Kobayashi, Yuko: 3 articles (06/2014 - 01/2012)
6.	An, Hyo-Jin: 2 articles (01/2021 - 03/2018)
7.	Kang, Yun-Mi: 2 articles (01/2021 - 03/2018)
8.	Lee, Minho: 2 articles (01/2021 - 03/2018)
9.	Nilsson, Gunnar: 2 articles (01/2021 - 08/2010)
10.	Huang, Wei: 2 articles (12/2017 - 10/2005)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2023 - "Upon intratumoral accumulation, the CaCO3 shell was decomposed at an acidic microenvironment to attenuate tumor acidity, accompanied by the release of Sal and Ca2+/A23187. " 01/01/2023 - "A23187 abolished the role of TGM2 in STAT1 and reversed the pro-tumor role of TGM2 in vitro and in vivo. " 01/01/2009 - "These data suggest that A23187 could be an alternative potential therapeutic drug used for anti-proliferation in LKB1-deficient cancer cells." 05/01/1990 - "In marked contrast, however, lymphocytes from a majority (8/11) of B-cell malignancies showed a suppression of the TPA-induced beta 2m production rate in response to the combined TPA/A23187 stimulus. " 02/01/1981 - "In contrast to A 23187, TPA did not induce degranulation of mast cells; whereas, in contrast with TPA, A 23187 did not show tumor-promoting activity. "
2.	Hypoxia (Hypoxemia) 11/01/2002 - "Hypoxia stimulated PAF synthesis via remodeling pathway only in PVSMC (408+/-32 vs 225+/-17) which was 5-fold greater than in PASMC (77+/-15 vs 105+/-24), however, with A23187 in remodeling pathway, PAF synthesis increased 5-fold compared to baseline conditions and then synthesis in hypoxia was greater than in normoxia in both cell types. " 01/01/1984 - "[Ca2+]i was raised experimentally in mammalian and amphibian skeletal and cardiac muscles by A23187, DNP, anoxia or the Ca2+ -paradox. " 08/23/2010 - "Hypoxia did not have any effect on A23187 induced degranulation or secretion of cytokines. " 12/15/2004 - "Transfection experiments with wild-type and hypoxia response element (HRE)-mutated PAI promoter constructs revealed that the HRE binding hypoxiainducible factor-1 (HIF-1) mediated the response to A23187 and BAPTA-am. Although A23187 induced a striking and stable induction of HIF-1alpha, BAPTA-am only mediated a fast and transient increase. " 10/01/2001 - "3. Responses to 5-CT were enhanced 3 - 4 fold in small pulmonary arteries from hypoxia-exposed, pulmonary hypertensive rats and neither L-NAME nor increasing tone with NPY, 4-AP, A23187, ET-1 or KCl had any further effect on responses to 5-CT. "
3.	Lung Neoplasms (Lung Cancer) 12/01/2003 - "Moreover, both plasma and bronchoalveolar lavage fluid obtained from treated subjects significantly reduced the production of PGE2 that resulted when a lung cancer cell line, A549, was stimulated with IL-1beta or A23187. " 07/01/2007 - "A23187 treatment is highly effective for the induction of GRP78 and subsequent development of resistance to VP-16 in the human lung cancer NCI-H460 cell line. " 10/01/2011 - "In this study, we investigated the up-regulation of GRP78 induced by A23187 and its association with the chemotherapeutical sensibility to cisplatin in human lung cancer cell line SPCA1. " 10/01/2011 - "To a certain extent, GRP78 up-regulation by A23187 was associated with the enhancement of drug sensitivity to cisplatin in human lung cancer cell line SPCA1." 01/01/2010 - "The aim of this study was to investigate the expression of GRP78 under the induction of A23187 and its significance in the resistance to anti-tumor drugs cisplatin in a human lung cancer SPCA-1 cell line. "
4.	Aneuploidy (Aneuploid) 01/01/2022 - "In this study, we investigated the safety and long-term efficacy of calcium ionophore (A23187) by analyzing its effects on fertilization, embryonic development, aneuploidy, and pregnancy outcomes in patients undergoing preimplantation genetic testing (PGT) cycles. " 01/01/2021 - "The purpose of this study was to analyze the effects of calcium ionophore (A23187) rescue activation on the activation of unfertilized oocytes, embryonic development potential, embryonic development timing and chromosomal aneuploidy, and to compare and analyze the clinical data of patients with calcium ionophore (A23187) activation in clinical application. "
5.	Pleurisy (Pleuritis) 07/01/1988 - "We also studied the involvement of endogenous prostaglandins (PGs) in the cytoprotective action of roxatidine and the effect of roxatidine on SRS content in pleurisy induced by A23187. " 01/01/1992 - "MK-886 was effective in Ascaris-induced asthma in squirrel monkeys, in rat carrageenan pleurisy, in rat Arthus pleurisy, and (topically) in guinea-pig ear oedema induced by A23187.(ABSTRACT TRUNCATED AT 400 WORDS)" 05/01/1989 - "The compound inhibited leukotriene biosynthesis in vivo in a rat pleurisy model (ED50, 0.2 mg/kg p.o.), an inflamed rat paw model (ED50, 0.8 mg/kg), a model of leukotriene excretion in rat bile following antigen provocation, and a model in the guinea-pig ear where leukotriene synthesis was induced by topical challenge with ionophore A23187 (ED50, 2.5 mg/kg p.o. " 10/01/1990 - "Pleural and peritoneal cells were collected at various times after pleurisy induction and tested for production of leukotriene B4 (LTB4), prostaglandin E2 (PGE2) and prostacyclin (PGI2) after in-vitro stimulation with calcium ionophore A23187. " 04/01/1997 - "The carrageenan-induced pleurisy model modifid by A23187 administration was used to study the oral effect of CGS 23885 (N-hydroxy-N-[(6-phenoxy-2H-1-benzopyran-3-yl)-methyl]urea), a potent 5-lipoxygenase (5-LO) inhibitor, on inflammatory parameters. "

Related Drugs and Biologics

1.	Calcium Ionophores
2.	Ionophores
3.	Endoplasmic Reticulum Chaperone BiP
4.	Cisplatin (Platino)
5.	Carrageenan
6.	anti-IgE antibodies
7.	Etoposide (VP 16)
8.	Egtazic Acid (EGTA)
9.	Ions
10.	Calcium Channels (Calcium Channel)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	bitter melon extract
3.	Lenses
4.	Aftercare (After-Treatment)
5.	Ligation