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(3,3')spiro((hexahydropyrrolo(1,2- a)pyrazine- 1,4- dione)- 6,3'- (2',3'- dihydrothieno(2,3- b)naphtho- 4',9'- dione))

an antineoplastic agent; structure in first source

Also Known As:

DTNQ-Pro

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - (3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione)): 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - (3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione)): 2
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - (3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione)): 2

Experts

1.	Campiglia, Pietro: 2 articles (01/2013 - 06/2010)
2.	Dicitore, Alessandra: 2 articles (01/2013 - 06/2010)
3.	Gomez-Monterrey, Isabel: 2 articles (01/2013 - 06/2010)
4.	Novellino, Ettore: 2 articles (01/2013 - 06/2010)
5.	Stiuso, Paola: 2 articles (01/2013 - 06/2010)
6.	Vanacore, Daniela: 2 articles (01/2013 - 06/2010)
7.	Caraglia, Michele: 1 article (01/2013)
8.	Lombardi, Angela: 1 article (01/2013)
9.	Scognamiglio, Ilaria: 1 article (01/2013)
10.	Aquino, Claudio: 1 article (06/2010)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 06/01/2010 - "These findings suggest the potential use of DTNQ-Pro in combination chemotherapy for colon cancer." 01/01/2013 - "DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment."
2.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2010 - "Using human colorectal carcinoma-derived Caco-2 cells as a model, we studied the effects of DTNQ-Pro on cellular viability and oxidative stress; HSP70 and HSP27 accumulation; and cell cycle, differentiation and apoptosis. "
3.	Neoplasms (Cancer) 01/01/2013 - "These effects could be due to enhanced DTNQ-Pro-induced membrane lipid peroxidation that, in turn, causes the sensitization of cancer cells to the cytotoxicity mediated by 5-FU."
4.	Carcinoma (Carcinomatosis) 06/01/2010 - "Recently, a quinone-based pentacyclic derivative, DTNQ-Pro, showed high cytotoxic activity in human colon carcinoma cell lines. "

Related Drugs and Biologics

1.	Membrane Lipids
2.	Fluorouracil (Carac)
3.	Dipeptides
4.	quinone (benzoquinone)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)