URB937

01/01/2019 - "Posttreatment with the FAAH inhibitor URB937 attenuated OLV-induced lung injury in rabbits and was associated with increased AEA levels and decreased levels of AA and its downstream metabolites."
01/01/2019 - "However, it remains unclear whether pharmacological inhibition of FAAH inhibitor using compounds such as URB937 can attenuate OLV-induced lung injury. "
08/01/2017 - "The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model."
01/01/2019 - "The FAAH inhibitor URB937 administered not before but 2.5 h after OLV attenuated OLV-induced lung injury by increasing AEA levels and reducing the levels of downstream metabolites including AA, PGI2, TXA2, and LTB4. "
08/01/2017 - "The data showed URB937 attenuated radiation-induced lung injury and increased endocannabinoid concentration in lung tissue. "

05/01/2012 - "The results indicate that the peripheral FAAH inhibitor URB937 is more effective than globally active FAAH inhibitors at inhibiting inflammatory pain. "
05/01/2012 - "In the present study, we conducted a comparative characterization of the effects of the newly identified brain-impermeant FAAH inhibitor, URB937 ([3-(3-carbamoylphenyl)-4-hydroxy-phenyl] N-cyclohexylcarbamate), in various rodent models of acute and persistent pain. "
12/01/2012 - "Nevertheless, URB937 produced a high degree of antinociception in female mice and rats in models of visceral and inflammatory pain. "
10/01/2015 - "The data suggest that URB937 is capable of changing, probably via indirect mechanisms, the functional status of central structures that are important for pain transmission in an animal model of migraine."
01/01/2020 - "At the dose that normalised bladder reflex activity and decreased pain responses, URB937 normalised the levels of anandamide and palmitoylethanolamine in the bladder. "

11/18/2023 - "Male Sprague-Dawley rats were subjected to chronic constriction injury of the infraorbital nerve (IoN-CCI); operated animals were treated sub-chronically with URB937 (1 mg/kg, i.p.) or vehicle before or after trigeminal mechanical allodynia establishment. "
10/01/2015 - "During the tail flick test, URB937 showed an antinociceptive effect in baseline conditions and it blocked NTG-induced hyperalgesia. "
11/18/2023 - "These findings suggest that URB937 may counteract, but not reverse, the development of allodynia in trigeminal neuralgia. "
11/18/2023 - "Here, we investigated the effect of URB937, a blood-brain barrier impermeant FAAH inhibitor, on experimentally induced mechanical allodynia in an animal model of trigeminal neuralgia. "
11/18/2023 - "URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia."

01/01/2019 - "We compared efficacy of chronic treatments with a centrally penetrant FAAH inhibitor (URB597), a peripherally restricted FAAH inhibitor (URB937) and an orthosteric pan-cannabinoid agonist (WIN55,212-2) in suppressing neuropathic pain induced by the chemotherapeutic agent paclitaxel. "

01/01/2021 - "The current study is aimed at profiling the behavioral and biochemical effects of URB937 in animal models of acute and chronic migraine. "
01/01/2021 - "Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine."
10/01/2015 - "The data suggest that URB937 is capable of changing, probably via indirect mechanisms, the functional status of central structures that are important for pain transmission in an animal model of migraine."
10/01/2015 - "Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine."
01/01/2021 - "We evaluated the effects of URB937 in two rat models that capture aspects of acute and chronic migraine, and are based on single or repeated administration of the vasodilating drug, nitroglycerin (NTG). "