2- (1,3- dimethyl- 2,6- dioxo- 1,2,3,6- tetrahydro- 7H- purin- 7- yl)- N- (4- isopropylphenyl)acetamide

a TRPA1 channel blocker

Also Known As:

HC 030031; HC-030031; HC030031

Networked: 80 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - Acetanilides: 7
        2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: 80
- Amides: 2428
  - Anilides: 22
    - Acetanilides: 7
      - 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: 80
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: 80

Experts

1.	Trevisan, Gabriela: 9 articles (07/2021 - 05/2013)
2.	Oliveira, Sara Marchesan: 8 articles (07/2021 - 06/2011)
3.	Geppetti, Pierangelo: 7 articles (01/2019 - 07/2011)
4.	Nassini, Romina: 7 articles (01/2019 - 07/2011)
5.	Ferreira, Juliano: 6 articles (05/2020 - 06/2011)
6.	Materazzi, Serena: 5 articles (01/2016 - 07/2011)
7.	Silva, Cássia Regina: 4 articles (07/2021 - 06/2011)
8.	de Almeida, Amanda Spring: 4 articles (07/2021 - 12/2018)
9.	Taylor, Bradley K: 4 articles (04/2020 - 04/2012)
10.	Fialho, Maria Fernanda Pessano: 3 articles (05/2020 - 01/2020)

Related Diseases

1.	Hyperalgesia 04/18/2019 - "When pretreated with the TRPA1 antagonist HC-030031, we found a significant reduction of thermal and mechanical hyperalgesia." 02/01/2020 - "HC030031 0.05 % reversed UVB-induced mechanical and cold allodynia, with maximum inhibition (Imax) of 69 ± 13 % and 100 % (on day 4), respectively. " 02/01/2017 - "The pharmacological antagonism (HC030031) or the down-regulation of TRPA1 greatly inhibited the mechanical hyperalgesia induced by DABK. " 01/01/2017 - "Injection of HC-030031 transiently reversed the cold allodynia. " 01/01/2017 - "HC-030031, a selective TRPA1 antagonist, was used to treat cold allodynia. "
2.	Airway Remodeling 01/01/2021 - "HC-030031 treatment also dramatically reduced leucocyte numbers and IL-8 level in the BAL fluid, inhibited lower airway remodeling and fibrosis, and nearly abolished BHR. "
3.	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 10/05/2023 - "In vivo and in vitro, HC-030031 reduced cisplatin-induced Scr and BUN level elevations; improved cisplatin-induced renal tissue injury, apoptosis, and mitochondrial dysfunction; elevated the reduced ERS-associated proteins glucose-regulated protein 78 (GRP78), glucose-regulated protein 75 (GRP75), and C/EBP homologous protein (CHOP) levels induced by cisplatin; reduced the elevated optic atrophy 1 (OPA1), mito-fusion 1 (MFN1), and mito-fusion 2 (MFN2) protein levels, and elevated phospho-dynamin-related protein 1 (p-DRP1) and mitochondrial fission factor (MFF) protein levels. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 10/05/2023 - "In vivo and in vitro, HC-030031 reduced cisplatin-induced Scr and BUN level elevations; improved cisplatin-induced renal tissue injury, apoptosis, and mitochondrial dysfunction; elevated the reduced ERS-associated proteins glucose-regulated protein 78 (GRP78), glucose-regulated protein 75 (GRP75), and C/EBP homologous protein (CHOP) levels induced by cisplatin; reduced the elevated optic atrophy 1 (OPA1), mito-fusion 1 (MFN1), and mito-fusion 2 (MFN2) protein levels, and elevated phospho-dynamin-related protein 1 (p-DRP1) and mitochondrial fission factor (MFF) protein levels. "
5.	Fibrosis (Cirrhosis) 01/01/2021 - "HC-030031 treatment also dramatically reduced leucocyte numbers and IL-8 level in the BAL fluid, inhibited lower airway remodeling and fibrosis, and nearly abolished BHR. "

Related Drugs and Biologics

1.	Amiloride (Midamor)
2.	Proteins (Proteins, Gene)
3.	Transcription Factor CHOP
4.	Dynamins (Dynamin)
5.	Interleukin-8 (Interleukin 8)
6.	Glucose (Dextrose)
7.	Cisplatin (Platino)
8.	Endoplasmic Reticulum Chaperone BiP
9.	glucose-regulated proteins
10.	capsazepine

Related Therapies and Procedures

1.	Spinal Injections
2.	Vagotomy
3.	Ligation
4.	Oral Administration