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lysomustine

a nitrosourea derivative of lysine; Antineoplastic Agents, Alkylating; structure in first source

Also Known As:

CRC 680578; lysomustin

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - lysomustine: 4
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - lysomustine: 4

Experts

1.	Belyavsky, Alexander V: 1 article (09/2016)
2.	Cheglakov, Ivan B: 1 article (09/2016)
3.	Karshieva, Saida S: 1 article (09/2016)
4.	Krassikova, Lyudmila S: 1 article (09/2016)
5.	Borisova, L M: 1 article (02/2014)
6.	Ermakova, K V: 1 article (02/2014)
7.	Kiselyova, M P: 1 article (02/2014)
8.	Kubasova, I Yu: 1 article (02/2014)
9.	Luk'yanets, E A: 1 article (02/2014)
10.	Meerovich, G A: 1 article (02/2014)

Related Diseases

1.	Lewis Lung Carcinoma 09/01/2016 - "In the present study, we estimated the efficacy of adipose tissue-derived mesenchymal stem cells (AT-MSCs) expressing cytosine deaminase (CDA) combined with lysomustine chemotherapy in mice bearing late stage Lewis lung carcinoma (LLC). " 09/01/2016 - "Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis lung carcinoma growth inhibition."
2.	Oligodendroglioma 02/01/2014 - "In glioblastoma 101/8, combined therapy with lysomustine or temodal led to prolongation of the lifespan by 127 %; 62.5 and 50 % rats were cured, respectively; in oligodendroglioma 14-4-9, animal lifespan was prolonged by 80 and 60 %, with 43 and 45 % rats cured, respectively. "
3.	Glioblastoma (Glioblastoma Multiforme) 02/01/2014 - "In glioblastoma 101/8, combined therapy with lysomustine or temodal led to prolongation of the lifespan by 127 %; 62.5 and 50 % rats were cured, respectively; in oligodendroglioma 14-4-9, animal lifespan was prolonged by 80 and 60 %, with 43 and 45 % rats cured, respectively. "
4.	Neoplasms (Cancer) 09/01/2016 - "Co-administration of lysomustine and AT-MSCs-CDA/UPRT + 5FC led to tumor growth inhibition (by 86%) and life span extension (by 60%) compared to the control group. "
5.	Leukemia L1210 08/01/1991 - "Alterations in DNA, RNA and protein syntheses, SH-group content, drug efflux, activities of replicative and repair enzymes, such as ribonucleotide reductase, thymidine kinase, O6-alkylguanine-DNA-alkyltransferase and DNA polymerases alpha and beta and damages of the DNA secondary structure were investigated in sensitive and resistant to CRC 680578 leukemia L1210 cells. "

Related Drugs and Biologics

1.	Cytosine Deaminase
2.	Temozolomide (Temodar)
3.	Thymidine Kinase
4.	RNA (Ribonucleic Acid)
5.	Ribonucleotide Reductases (Ribonucleotide Reductase)
6.	Proteins (Proteins, Gene)
7.	Enzymes
8.	DNA-Directed DNA Polymerase (Polymerases, DNA)
9.	DNA (Deoxyribonucleic Acid)
10.	hydroxyaluminum tetra-3-phenylthiophthalocyanine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Photochemotherapy (Photodynamic Therapy)