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PF-4708671

Also Known As:

(2-(4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo(d)imidazole

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - PF-4708671: 9
  - Piperazines: 26
    - PF-4708671: 9

Experts

1.	Chi, Oak Z: 2 articles (10/2020 - 07/2019)
2.	Jacinto, Estela: 2 articles (10/2020 - 07/2019)
3.	Kiss, Geza K: 2 articles (10/2020 - 07/2019)
4.	Liu, Xia: 2 articles (10/2020 - 07/2019)
5.	Mellender, Scott J: 2 articles (10/2020 - 07/2019)
6.	Weiss, Harvey R: 2 articles (10/2020 - 07/2019)
7.	Bellmann, Kerstin: 2 articles (01/2019 - 03/2016)
8.	Marette, André: 2 articles (01/2019 - 03/2016)
9.	Shum, Michael: 2 articles (01/2019 - 03/2016)
10.	St-Pierre, Philippe: 2 articles (01/2019 - 03/2016)

Related Diseases

1.	Glucose Intolerance 03/01/2016 - "Indeed, while rapamycin treatment induced glucose intolerance and failed to improve Akt phosphorylation in liver and muscle of HF-fed mice, PF-4708671 treatment improved glucose tolerance and increased Akt phosphorylation in metabolic tissues of these obese mice. "
2.	Neoplasms (Cancer) 03/28/2017 - "Comparison of the growth-inhibitory profile of EHT1864 to 137 other anti-cancer drugs across 656 cancer cell lines revealed significant correlation with the p70S6K inhibitor PF-4708671. " 03/01/2015 - "Furthermore, the combination of OSI-906 and PF-4708671, a p70S6K1 inhibitor, efficiently suppresses the growth of OSI-906-resistant colon tumor cells in vitro and in vivo. " 03/01/2015 - "Taken together, activation of p70S6K1 that is inhibited by Pdcd4 is essential for resistance to the IGF-1R inhibitor in colon tumor cells, and the combinational treatment of OSI-906 and PF-4708671 results in enhanced antiproliferation effects in colorectal cancer cells in vitro and in vivo, providing a novel venue to overcome the resistance to the IGF-1R inhibitor in treating colorectal cancer."
3.	Insulin Resistance 01/01/2019 - "Recently, we showed that the S6K1 inhibitor PF-4708671 (PF) increases insulin sensitivity. " 03/01/2016 - "We also treated high-fat (HF)-fed obese mice for 7 days with PF-4708671 in comparison with rapamycin to assess glucose tolerance, insulin resistance and insulin signalling in vivo. "
4.	Infarction (Infarctions) 10/01/2020 - "LPA increased the percentage of cortical infarct out of total cortical area (+36%) and PF-4708671 pretreatment prevented the increase of the infarct size. " 07/15/2019 - "With PF-4708671, a significant decrease in pT1135 Rictor was observed and the percentage of cortical infarct out of total cortical area was decreased (11.6 ± 2.0% vs 7.2 ± 1.1%, P < 0.0001). " 07/15/2019 - "Our data demonstrate that PF-4708671 decreased the size of the cortical infarct in the ischemic-reperfused cortex with a decrease in BBB disruption suggesting that inhibition of S6K1 may induce neuronal survival in early cerebral ischemia-reperfusion and that a decrease of BBB disruption could be one of the contributing factors." 07/15/2019 - "Inhibition of p70 ribosomal S6 kinase 1 (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability."
5.	Carcinogenesis 01/01/2016 - "Importantly, PF-4708671 could inhibit tumorigenesis in nude mice in vivo. " 01/01/2016 - "These findings demonstrated that the p70S6K specific inhibitor PF-4708671 has inhibitory effects on NSCLC tumorigenesis in vitro and in vivo. "

Related Drugs and Biologics

1.	Sirolimus (Rapamycin)
2.	Glucose (Dextrose)
3.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
4.	Ribosomal Protein S6 Kinases (S6 Kinase)
5.	Insulin (Novolin)
6.	3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanol
7.	EHT 1864
8.	polypeptide 1 70kD ribosomal protein S6 kinase