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AZ 12216052

an mGluR8 modulator; structure in first source

Also Known As:

AZ-12216052; AZ12216052

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Grygier, Beata: 1 article (10/2018)
2.	Jantas, Danuta: 1 article (10/2018)
3.	Lasoń, Władysław: 1 article (10/2018)
4.	Zatorska, Justyna: 1 article (10/2018)
5.	Greda, A: 1 article (09/2015)
6.	Grygier, B: 1 article (09/2015)
7.	Jantas, D: 1 article (09/2015)
8.	Lason, W: 1 article (09/2015)
9.	Leskiewicz, M: 1 article (09/2015)
10.	Pilc, A: 1 article (09/2015)

Related Diseases

1.

10/01/2018 - "Based on our recent data on high expression of mGluR8 in human neuroblastoma SH-SY5Y cells, in this study, we evaluated the effect of an mGluR8-specific positive allosteric modulator (PAM: AZ12216052) and orthosteric agonist [(S)-3,4-DCPG ((S)-3,4-dicarboxyphenylglycine)] on chemotherapeutic (doxorubicin, irinotecan or cisplatin)-evoked cell damage in undifferentiated (UN-) and retinoic acid-differentiated (RA-) SH-SY5Y cells. "
09/01/2015 - "Thus, the comparison of the neuroprotective potency of the mGluR II agonist LY354740, mGluR III agonist ACPT-I, mGluR4 PAM VU0361737, mGluR8 PAM AZ12216052 and allosteric mGluR7 agonist AMN082 against staurosporine (St-) and doxorubicin (Dox)-induced cell death has been performed in undifferentiated (UN-) and retinoic acid differentiated (RA-) human neuroblastoma SH-SY5Y cells. "

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Doxorubicin (Adriamycin)
3.	metabotropic glutamate receptor 8
4.	Cisplatin (Platino)
5.	Irinotecan (Camptosar)
6.	Staurosporine
7.	N- (4- chloro- 3- methoxyphenyl)- 2- picolinamide
8.	N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
9.	metabotropic glutamate receptor 4
10.	1-aminocyclopentane-1,3,4-tricarboxylic acid