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5- (6- (1- azabicyclo(2,2,2)oct- 3- yloxy)pyridazin- 3- yl)- 1H- indole

a nicotinic agonist; structure in first source

Also Known As:

ABT 107; ABT-107; ABT107

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Quinuclidines: 20
    - 5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole: 5

Experts

1.	Decker, Michael W: 3 articles (12/2015 - 09/2010)
2.	McGregor, Matthew: 2 articles (12/2015 - 10/2014)
3.	Quik, Maryka: 2 articles (12/2015 - 10/2014)
4.	Zhang, Danhui: 2 articles (12/2015 - 10/2014)
5.	Anderson, David J: 2 articles (09/2010 - 09/2010)
6.	Bunnelle, William H: 2 articles (09/2010 - 09/2010)
7.	Gopalakrishnan, Murali: 2 articles (09/2010 - 09/2010)
8.	Bordia, Tanuja: 1 article (12/2015)
9.	McIntosh, J Michael: 1 article (12/2015)
10.	Perez, Xiomara A: 1 article (12/2015)

Related Diseases

1.	Dyskinesias (Dyskinesia) 10/01/2014 - "The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys." 12/01/2015 - "They were treated with levodopa/carbidopa, administered the α7 agonist ABT-107 (n = 6), ABT-894 (n = 6), nicotine (n = 5), or vehicle (n = 6) and dyskinesias evaluated. "
2.	Alzheimer Disease (Alzheimer's Disease) 09/01/2010 - "In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease." 04/01/2011 - "ABT-107 is a potent, selective α7 nicotinic receptor agonist under development for treatment of Alzheimer's disease and cognitive deficits associated with schizophrenia. "
3.	Parkinsonian Disorders (Parkinsonism) 10/01/2014 - "ABT-107 had no effect on Parkinsonism or cognitive performance. "
4.	Schizophrenia (Dementia Praecox) 04/01/2011 - "ABT-107 is a potent, selective α7 nicotinic receptor agonist under development for treatment of Alzheimer's disease and cognitive deficits associated with schizophrenia. "
5.	Neuroblastoma 09/01/2010 - "Functionally, ABT-107 did not evoke detectible currents in Xenopus oocytes expressing human or nonhuman alpha3beta4, chimeric (alpha6/alpha3)beta4, or 5-HT(3A) receptors, and weak or negligible Ca(2+) responses in human neuroblastoma IMR-32 cells (alpha3* function) and human alpha4beta2 and alpha4beta4 nAChRs expressed in human embryonic kidney 293 cells. "

Related Drugs and Biologics

1.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
2.	Levodopa (L Dopa)
3.	Nicotine
4.	Carbidopa (Lodosyn)
5.	3- (5,6- dichloropyridin- 3- yl)- 3,6- diazabicyclo(3.2.0)heptane