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PEGylated tumor necrosis factor-related apoptosis-inducing ligand

anineoplastic agent derived from a trimeric version of TRAIL

Also Known As:

PEG-HZ-TRAIL

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Tae Hyung: 2 articles (02/2014 - 06/2010)
2.	Lee, Kang Choon: 2 articles (02/2014 - 06/2010)
3.	Youn, Yu Seok: 2 articles (02/2014 - 06/2010)
4.	Byeon, Hyeong Jun: 1 article (02/2014)
5.	Choi, Ji Su: 1 article (02/2014)
6.	Choi, Seong Ho: 1 article (02/2014)
7.	Lee, Eun Seong: 1 article (02/2014)
8.	Chae, Su Young: 1 article (06/2010)
9.	Chen, Xiaoyuan: 1 article (06/2010)
10.	Jin, Cheng-Hao: 1 article (06/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2010 - "Improved antitumor activity and tumor targeting of NH(2)-terminal-specific PEGylated tumor necrosis factor-related apoptosis-inducing ligand." 06/01/2010 - "Furthermore, in vivo antitumor tests revealed that PEG-HZ-TRAIL treatment enhanced therapeutic potentials compared with HZ-TRAIL in tumor xenograft animal models, and these enhancements were attributed to its better pharmacokinetic properties and tumor-targeting performance. " 06/01/2010 - "Although slight activity loss occurred after PEGylation, PEG-HZ-TRAIL showed excellent tumor cell-specific cytotoxic effects via apoptotic pathways with negligible normal cell toxicity. " 06/01/2010 - "These findings show that PEG-HZ-TRAIL administration provides an effective antitumor treatment, which exhibits superior tumor targeting and better inhibits tumor growth, and suggest that PEG-HZ-TRAIL should be considered a potential candidate for antitumor biotherapy."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2014 - "The purpose of this study was to demonstrate the apoptotic activity and antitumor effect of PEGylated tumor necrosis factor-related apoptosis-inducing ligand (PEG-TRAIL) in pancreatic carcinoma Mia Paca-2 cells and in Mia Paca-2 cell-xenografted mice. "

Related Therapies and Procedures

1.	Biological Therapy