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prolyl-glycyl-prolyl-leucine

Also Known As:

Pro-Gly-Pro-Leu

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - prolyl-glycyl-prolyl-leucine: 6

Experts

1.	Andreeva, L A: 4 articles (11/2014 - 05/2010)
2.	Lyapina, L A: 3 articles (11/2014 - 12/2011)
3.	Shubina, T A: 3 articles (11/2014 - 05/2010)
4.	Grigor'eva, M E: 2 articles (11/2014 - 01/2013)
5.	Myasoedov, N F: 2 articles (11/2014 - 11/2013)
6.	Obergan, T Yu: 2 articles (11/2014 - 11/2013)
7.	Rochev, D L: 2 articles (11/2013 - 12/2011)
8.	Liapina, L A: 2 articles (01/2013 - 05/2010)
9.	Miasoedov, N F: 2 articles (01/2013 - 05/2010)
10.	Obergan, T Iu: 2 articles (01/2013 - 05/2010)

Related Diseases

1.	Hypercholesterolemia 11/01/2014 - "Hypoglycemic and anticoagulant effects of tetrapeptide Pro-Gly-Pro-Leu in hypercholesterolemia." 03/01/2016 - "Comparative analysis of the hypocholesterolemic and antithrombotic action of small regulatory glyproline peptides (Pro-Gly-Pro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu) was performed on an experimental hypercholesterolemia model of rats. " 11/01/2014 - "In rats with experimental hypercholesterolemia, 7-fold intranasal administration of the peptide Pro-Gly-Pro-Leu in a dose of 200 μg/kg body weight prevented the increase in blood glucose level and produced an anticoagulant effect. "
2.	Body Weight (Weight, Body) 11/01/2014 - "In rats with experimental hypercholesterolemia, 7-fold intranasal administration of the peptide Pro-Gly-Pro-Leu in a dose of 200 μg/kg body weight prevented the increase in blood glucose level and produced an anticoagulant effect. " 01/01/2013 - "In the present paper anticoagulant-fibrinolytic effects of the peptide Pro-Gly-Pro-Leu in rats (370-500 g body weight) who consumed fatty foods with excess of saturated fatty acids (wheat flour and bread--35%, sugar--10%, margarine hydrogenated fats, mayonnaise, cheese--35% and offals--10%, cholesterol--1%, dry food--9%) has been established. "
3.	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 11/01/2013 - "Leucine-containing glyprolines (Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro): Participation in hemostatic reactions in vitro and in vivo in rats with blood coagulation and lipid metabolism disorders."
4.	Thrombosis (Thrombus) 12/01/2011 - "Effects of peptide Pro-Gly-Pro-Leu under conditions of normal hemostasis and thrombus formation in rats."
5.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/01/2010 - "Repeated (over 7 days) intranasal introduction of the Pro-Gly-Pro-Leu peptide into animals at a dose of 1 mg/kg before injection of the diabetogenic metabolite alloxan provided effective protection of an organism against development of insulin-dependent diabetes mellitus and prevented development of hypercoagulating alterations in the system of hemostasis. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Anticoagulants
3.	Margarine
4.	Leucine (L-Leucine)
5.	Hypoglycemic Agents (Hypoglycemics)
6.	Hemostatics (Antihemorrhagics)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Fats
9.	Cholesterol
10.	Blood Glucose (Blood Sugar)

Related Therapies and Procedures

1.	Intranasal Administration