ACM-14 peptide

has antineoplastic activity; a synthetic peptide derived from a mutated version of the cytoplasmic domain of MT1-MMP and the cell-penetrating domain of a helix from Drosophila antennapedia

Also Known As:

antennapedia-coupled cytoplasmic MMP-14

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Biotin: 4061
        ACM-14 peptide: 1
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Biotin: 4061
    - ACM-14 peptide: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - ACM-14 peptide: 1

Experts

1.	Béliveau, Richard: 1 article (06/2010)
2.	Gingras, Denis: 1 article (06/2010)
3.	Nyalendo, Carine: 1 article (06/2010)
4.	Sartelet, Hervé: 1 article (06/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2010 - "In this work, we show that the non phosphorylizable cell-permeable peptide antennapedia-coupled cytoplasmic MMP-14 (ACM-14), consisting of the mutated (Y573F) cytoplasmic domain of MT1-MMP coupled to antennapedia, inhibits tyrosine phosphorylation of the enzyme and markedly reduces tumor cell proliferation within 3D type I collagen matrices. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase 14 (MT1-MMP)
2.	Collagen Type I (Type I Collagen)
3.	Tyrosine (L-Tyrosine)
4.	Peptides (Polypeptides)
5.	Enzymes