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bis(propyl)cognitin

a GABA-A receptor antagonist

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        Tacrine: 772
        bis(propyl)cognitin: 6

Experts

1.	Han, Yifan: 4 articles (01/2020 - 06/2010)
2.	Hu, Shengquan: 2 articles (01/2020 - 01/2019)
3.	Cui, Wei: 2 articles (01/2019 - 08/2016)
4.	Pang, Yuanping: 2 articles (01/2019 - 06/2010)
5.	Tang, Jing: 2 articles (01/2019 - 06/2010)
6.	Wang, Qinwen: 2 articles (01/2016 - 06/2010)
7.	Sun, Weiwen: 1 article (01/2020)
8.	Tang, Yanyan: 1 article (01/2020)
9.	Xu, En: 1 article (01/2020)
10.	Zhan, Lixuan: 1 article (01/2020)

Related Diseases

1.	Infarction (Infarctions) 01/01/2019 - "Although all infarct groups improved over time, the combination of bis(propyl)-cognitin and treadmill exercise effectively enhanced motor recovery during 14-day intervention. " 01/01/2019 - "Rats were distributed into 3 treatment groups: infarct/bis(propyl)-cognitin(drug only group, DO); infarct/treadmill exercise(exercise only group, EO); infarct/bis(propyl)-cognitin + treadmill exercise (drug + exercise group, DE). "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2020 - "In the current study, the neuroprotective effects of bis(propyl)-cognitin (B3C), a multifunctional dimer, against secondary damage in the VPN of ipsilateral thalamus were investigated in a distal middle cerebral artery occlusion (dMCAO) stroke model in adult rats. " 06/25/2010 - "Under glutamate-mediated pathological conditions, bis(propyl)-cognitin, in contrast to bis(heptyl)-cognitin, prevented excitotoxicity with increasing effectiveness against escalating levels of glutamate and much more effectively protected against middle cerebral artery occlusion-induced brain damage than did memantine. "
3.	Stroke (Strokes) 01/01/2020 - "In the current study, the neuroprotective effects of bis(propyl)-cognitin (B3C), a multifunctional dimer, against secondary damage in the VPN of ipsilateral thalamus were investigated in a distal middle cerebral artery occlusion (dMCAO) stroke model in adult rats. "
4.	Ischemic Stroke 01/01/2019 - "We investigated the molecular mechanisms by which the combination of bis(propyl)-cognitin, an uncompetitive antagonist of NMDA receptor, and treadmill exercise promote rehabilitation after ischemic stroke. " 01/01/2019 - "Our study reveals that bis(propyl)-cognitin potentiated rehabilitation of treadmill exercise after ischemic stroke, possibly via regulating brain VEGF expression, indicating that the combination of NMDA receptor antagonists and exercise might be useful for stroke rehabilitation."
5.	Brain Infarction 01/01/2019 - "Both bis(propyl)-cognitin and treadmill exercise significantly elevated brain VEGF expression and decreased brain infarct volume at 14 day post-ischemia. "

Related Drugs and Biologics

1.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Neuroprotective Agents
4.	bis(heptyl)cognitin
5.	Glutamic Acid (Glutamate)
6.	Tacrine (Cognex)
7.	Memantine (Namenda)
8.	Amyloid (Amyloid Fibrils)
9.	rasagiline (Azilect)

Related Therapies and Procedures

1.	Stroke Rehabilitation
2.	Therapeutics