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21- (2- (N,N- dimethylamino)ethyl)oxy- 7a- methyl- 19- norpregna- 1,3,5(10),17(20)- tetraen- 3- ol

an estrogen-related receptor alpha antagonist; structure in first source

Also Known As:

SR 16388; SR-16388; SR16388

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        Estradiol: 14115
        21-(2-(N,N-dimethylamino)ethyl)oxy-7a-methyl-19-norpregna-1,3,5(10),17(20)-tetraen-3-ol: 2
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Estradiol: 14115
        21-(2-(N,N-dimethylamino)ethyl)oxy-7a-methyl-19-norpregna-1,3,5(10),17(20)-tetraen-3-ol: 2

Experts

1.	Chao, Wan-Ru: 2 articles (03/2011 - 09/2010)
2.	Collins, Nathan: 2 articles (03/2011 - 09/2010)
3.	Hobbs, Peter: 2 articles (03/2011 - 09/2010)
4.	Sambucetti, Lidia: 2 articles (03/2011 - 09/2010)
5.	Alt, Carsten: 1 article (03/2011)
6.	Amin, Khalid: 1 article (03/2011)
7.	Dinh, Dominic: 1 article (03/2011)
8.	Hou, Carol: 1 article (03/2011)
9.	Jong, Ling: 1 article (03/2011)
10.	Laderoute, Keith: 1 article (03/2011)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2011 - "Together, these effects of SR16388 can lead to the reduction of vascularization and tumor growth in vivo." 09/15/2010 - "Representative in vivo results show that SR16388 inhibited the growth of human prostate tumor xenografts in nude mice as a single agent at 30mg/kg given once daily and 100mg/kg given once weekly. " 09/15/2010 - "In a combination study, SR16388 (10mg/kg, once daily) and paclitaxel (7.5mg/kg, twice weekly) inhibited the growth of prostate tumor xenografts in nude mice by 61% compared to untreated xenograft tumors. " 03/01/2011 - "SR16388: a steroidal antiangiogenic agent with potent inhibitory effect on tumor growth in vivo."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/01/2011 - "More importantly, SR16388 down-regulated the pro-angiogenic transcription factors, hypoxia inducible factor 1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) in non-small cell lung cancer (NSCLC) cells. "
3.	Hypoxia (Hypoxemia) 03/01/2011 - "More importantly, SR16388 down-regulated the pro-angiogenic transcription factors, hypoxia inducible factor 1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) in non-small cell lung cancer (NSCLC) cells. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
3.	Angiogenesis Inhibitors
4.	Transcription Factors (Transcription Factor)