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6- (3- (piperazin- 1- yl)propanoyl)benzo(d)oxazol- 2(3H)- one

an autotaxin inhibitor

Also Known As:

PF 8380; PF-8380; PF8380

Networked: 12 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 6-(3-(piperazin-1-yl)propanoyl)benzo(d)oxazol-2(3H)-one: 12
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazoles: 68
      - 6-(3-(piperazin-1-yl)propanoyl)benzo(d)oxazol-2(3H)-one: 12

Experts

1.	Lai, Zhen-Zhen: 1 article (10/2022)
2.	Li, Da-Jin: 1 article (10/2022)
3.	Li, Ming-Qing: 1 article (10/2022)
4.	Mei, Jie: 1 article (10/2022)
5.	Shi, Jia-Wei: 1 article (10/2022)
6.	Wang, Jian: 1 article (10/2022)
7.	Yang, Hui-Li: 1 article (10/2022)
8.	Ye, Jiang-Feng: 1 article (10/2022)
9.	Zhang, Tao: 1 article (10/2022)
10.	Zhao, Jian-Yuan: 1 article (10/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "Heterotopic mouse GL261 tumors were used to evaluate the efficacy of PF-8380 as a radiosensitizer. " 02/01/2021 - "An in vitro study using two PDAC cell lines, AsPC-1 and PANC-1, showed that ATX-LPA signaling promoted cancer cell migration via the activation of the downstream signaling, and this increased cell migration was suppressed by an ATX inhibitor, PF-8380. " 01/01/2013 - "In a heterotopic mouse GL261 tumors untreated mice took 11.2 days to reach a tumor volume of 7000 mm(3), however combination of PF-8380 (10 mg/kg) with irradiation (five fractions of 2 Gy) took more than 32 days to reach a tumor volume of 7000 mm(3). " 01/01/2013 - "Clonogenic survival assays and tumor transwell invasion assays were performed using PF-8380 to evaluate role of ATX in survival and invasion. "
2.	Inflammation (Inflammations) 11/01/2018 - "Moreover, expression of Na+/H+ exchanger 3 was also improved by PF-8380, suggesting that suppression of inflammation by PF-8380 enhanced IEC differentiation. " 07/01/2010 - "PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation." 07/01/2010 - "The specific inhibitor PF-8380, dosed orally at 30 mg/kg, provided >95% reduction in both plasma and air pouch LPA within 3 h, indicating autotaxin is a major source of LPA during inflammation. " 08/07/2021 - "In terms of the communication between systemic inflammation and neuroinflammation, both inhibitors significantly attenuated LPS-mediated systemic TNFα and IL-6 synthesis, while IL-1β was only reduced by PF8380. "
3.	Ascites 02/01/2021 - "An in vivo study showed that PF-8380 suppressed peritoneal dissemination and decreased malignant ascites, and these results were validated by the biological analysis as well as the in vitro study. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2013 - "Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines." 02/01/2013 - "However, analogs 8 and 9, bearing only the benzo[d]oxazol-2(3H)-one moiety, are more cytotoxic on the LN229 glioblastoma cell line than PF-8380 and temozolomide (TMZ)."
5.	Neuroinflammatory Diseases 10/05/2022 - "We demonstrate that the autotaxin (ATX) inhibitor PF-8380 attenuates neuroinflammation and improves neurological dysfunction in the mouse model of HE. " 08/07/2021 - "In terms of the communication between systemic inflammation and neuroinflammation, both inhibitors significantly attenuated LPS-mediated systemic TNFα and IL-6 synthesis, while IL-1β was only reduced by PF8380. "

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