bisleuconothine A

an antineoplastic agent isolated from the bark of Leuconotis griffithii; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2016 - "Our study found that Bisleuconothine A down-regulated the endogenous Wnt target gene expression through promoting phosphorylation of β-catenin and the subsequent inhibition of its nuclear translocation in HCT116 and SW480 colorectal cancer cells. " 03/01/2016 - "In vitro, Bisleuconothine A inhibited cell proliferation through induction of apoptosis by increasing the cleavage of caspases in HCT116 and SW480 colorectal cancer cells. " 03/01/2016 - "Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling."
2.	Neoplasms (Cancer) 03/01/2016 - "Moreover, in vivo, Bisleuconothine A dramatically suppressed tumor growth in HCT116 Xenograft. " 03/15/2010 - "Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines."