HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

marein

hypoglycemic from Coreopsis tinctoria; structure in first source

Networked: 8 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mao, Xinmin: 2 articles (11/2020 - 01/2019)
2.	Yao, Lan: 2 articles (11/2020 - 01/2019)
3.	He, Chunnian: 2 articles (08/2016 - 01/2016)
4.	Hu, Keping: 2 articles (08/2016 - 01/2016)
5.	Jiang, Baoping: 2 articles (08/2016 - 01/2016)
6.	Le, Liang: 2 articles (08/2016 - 01/2016)
7.	Xiao, Peigen: 2 articles (08/2016 - 01/2016)
8.	Xu, Lijia: 2 articles (08/2016 - 01/2016)
9.	Huang, Jie: 1 article (01/2021)
10.	Niu, Guanghao: 1 article (01/2021)

Related Diseases

1.	Glucose Metabolism Disorders 08/15/2016 - "Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells."
2.	Insulin Resistance 08/15/2016 - "Here we investigate the effect and mechanism of action of marein on improving insulin resistance in HepG2 cells. " 08/15/2016 - "Consequently, marein improved insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. "
3.	Diabetic Nephropathies (Diabetic Nephropathy) 11/01/2020 - "Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells."
4.	Carcinoma (Carcinomatosis) 08/15/2016 - "We investigated the protective effects of marein in high glucose-induced human liver carcinoma cell HepG2. "
5.	Hypoxia (Hypoxemia) 01/01/2021 - "Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells." 01/01/2021 - "Treating angiotensin II/hypoxia-stimulated H9c2 cells with marein led to decreasing cell surface area, intracellular total protein, atrial natriuretic peptide, and free fatty acids levels, but increasing glucose level. " 01/01/2021 - "Marein treatment decreased hypoxia inducible factor-1α (HIF-1α), peroxisome proliferator activated receptor γ (PPARγ), medium chain acyl-coenzyme A dehydrogenase, glucose transporter-4, and glycerol-3-phosphate acyltransferase protein expressions, and increased PPARα, fatty acid transport protein-1, carnitine palmitoyltransferase-1, and pyruvate dehydrogenase kinase-4 protein expressions. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Calcium-Calmodulin-Dependent Protein Kinase Kinase
3.	Sodium-Glucose Transporter 2
4.	Glycogen
5.	tert-Butylhydroperoxide
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Cytokines
8.	Proteins (Proteins, Gene)
9.	Peroxisome Proliferator-Activated Receptors (PPAR)
10.	Therapeutic Uses