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OT-551

a small molecule with antioxidant and anti-inflammatory effects

Also Known As:

1-hydroxy-4-cyclopropanecarbonyloxy-2,2,6,6-tetramethylpiperidine hydrochloride

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - OT-551: 3

Experts

1.	Brunt, Vienna E: 1 article (01/2015)
2.	Li, Weixing: 1 article (01/2015)
3.	Minson, Christopher T: 1 article (01/2015)
4.	Tao, Albert: 1 article (01/2015)
5.	Vallerga, Anne K: 1 article (01/2015)
6.	Zarling, David A: 1 article (01/2015)
7.	Zarling, Jacob A: 1 article (01/2015)
8.	Chew, Emily Y: 1 article (12/2010)
9.	Cukras, Catherine: 1 article (12/2010)
10.	Cunningham, Denise: 1 article (12/2010)

Related Diseases

1.	Geographic Atrophy 12/01/2010 - "To investigate the safety and preliminary efficacy of OT-551, a disubstituted hydroxylamine with antioxidant properties, for the treatment of geographic atrophy (GA), the advanced atrophic form of age-related macular degeneration (AMD). "
2.	Macular Degeneration (Age-Related Maculopathy) 12/01/2010 - "To investigate the safety and preliminary efficacy of OT-551, a disubstituted hydroxylamine with antioxidant properties, for the treatment of geographic atrophy (GA), the advanced atrophic form of age-related macular degeneration (AMD). "
3.	Inflammation (Inflammations) 01/01/2009 - "Some of them are already available in human trials or even approved vascular epithelial growth factor (VEGF) blockers such as Macugen, Lucentis, Avastin, VEGF Trap-Eye and Cand5; VEGF receptor blockers such as TG100801, vatalanib, pazopanib, Sirna-027 and a vaccine approach; inflammation inhibitors and immunosuppressants such as Retaane, Kenalog, ARC1905, POT-4, OT-551. "
4.	Neoplasms (Cancer) 01/01/2015 - "Tempol (TP), Tempol Hydroxylamine (TP-H), and TP-H prodrug (OT-551) are evaluated in (1) non-smokers versus smokers with cutaneous microvascular dysfunction, rapidly reversed by cutaneous TP; (2) elderly cancer patients at risk for radiation-induced skin burns or hair loss, prevented by topical TP; and (3) elderly smoker or non-smoker AMD patients at risk for vision loss, prevented by daily eye drops of OT-551. "
5.	Burns 01/01/2015 - "Tempol (TP), Tempol Hydroxylamine (TP-H), and TP-H prodrug (OT-551) are evaluated in (1) non-smokers versus smokers with cutaneous microvascular dysfunction, rapidly reversed by cutaneous TP; (2) elderly cancer patients at risk for radiation-induced skin burns or hair loss, prevented by topical TP; and (3) elderly smoker or non-smoker AMD patients at risk for vision loss, prevented by daily eye drops of OT-551. "

Related Drugs and Biologics

1.	Hydroxylamine (Hydroxylamine Hydrochloride)
2.	Antioxidants
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Vaccines
7.	Triamcinolone Acetonide (Azmacort)
8.	Immunosuppressive Agents (Immunosuppressants)
9.	Ranibizumab (Lucentis)
10.	Bevacizumab (Avastin)