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N- (2- diethylaminoethyl)- 4- (4- fluorobenzamido)- 5- iodo- 2- methoxybenzamide

melanin-binding compound that may be useful as radiopharmaceutical against melanoma; structure in first source

Also Known As:

MIP 1145; MIP-1145; MIP1145

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Aglan, H: 1 article (01/2016)
2.	El-Kafrawy, A F: 1 article (01/2016)
3.	Kandil, S A: 1 article (01/2016)
4.	Seddik, U: 1 article (01/2016)
5.	Babich, John W: 1 article (05/2010)
6.	Barrett, John A: 1 article (05/2010)
7.	Boyd, Marie: 1 article (05/2010)
8.	Chen, Jianqing: 1 article (05/2010)
9.	Dinkelborg, Ludger: 1 article (05/2010)
10.	Friebe, Matthias: 1 article (05/2010)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2016 - "Radioiodinated MIP-1145, which specifically targets melanin, is an ideal candidate for targeted therapy of melanoma. " 05/15/2010 - "The melanin-specific binding of [(131)I]MIP-1145 combined with prolonged tumor retention, the ability to significantly inhibit tumor growth, and acceptable projected human dosimetry suggest that it may be effective as a radiotherapeutic pharmaceutical for treating patients with metastatic malignant melanoma." 05/15/2010 - "In human melanoma xenografts, [(131)I]MIP-1145 exhibited diffuse tissue distribution and washout from all tissues except melanin-expressing tumors. " 05/15/2010 - "The binding of [(131)I]MIP-1145 to melanoma cells in vitro was melanin dependent, increased over time, and insensitive to mild acid treatment, indicating that it was retained within cells. "
2.	Neoplasms (Cancer) 05/15/2010 - "The administration of [(131)I]MIP-1145 at 25 MBq or 2.5 GBq/m(2) in single or multiple doses significantly reduced SK-MEL-3 tumor growth, with multiple doses resulting in tumor regression and a durable response for over 125 days. " 05/15/2010 - "The melanin-specific binding of [(131)I]MIP-1145 combined with prolonged tumor retention, the ability to significantly inhibit tumor growth, and acceptable projected human dosimetry suggest that it may be effective as a radiotherapeutic pharmaceutical for treating patients with metastatic malignant melanoma." 05/15/2010 - "In human melanoma xenografts, [(131)I]MIP-1145 exhibited diffuse tissue distribution and washout from all tissues except melanin-expressing tumors. "

Related Drugs and Biologics

1.	Melanins (Melanin)
2.	Acids

Related Therapies and Procedures

1.	Therapeutics