3- (((3- carboxycyclohexyl)amino)carbonyl)- 4- (3- (4- (4- (cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid

a cysteinyl leukotriene 2 (CysLT2) receptor antagonist; structure in first source

Also Known As:

HAMI 3379; HAMI-3379; HAMI3379

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexanecarboxylic Acids
        3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid: 6
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - 3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid: 6
    - Cyclohexanecarboxylic Acids
      - 3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid: 6

Experts

1.	Fang, San-Hua: 2 articles (08/2013 - 11/2012)
2.	Lu, Yun-Bi: 2 articles (08/2013 - 11/2012)
3.	Shi, Qiao-Juan: 2 articles (08/2013 - 11/2012)
4.	Wang, Xiao-Rong: 2 articles (08/2013 - 11/2012)
5.	Wei, Er-Qing: 2 articles (08/2013 - 11/2012)
6.	Xu, Dong-Min: 2 articles (08/2013 - 11/2012)
7.	Yu, Shu-Ying: 2 articles (08/2013 - 11/2012)
8.	Zhang, Wei-Ping: 2 articles (08/2013 - 11/2012)
9.	Zhang, Xia-Yan: 2 articles (08/2013 - 11/2012)
10.	Chen, Xiaojin: 1 article (07/2022)

Related Diseases

1.	Stroke (Strokes) 07/24/2022 - "CysLT2R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils."
2.	Meningitis 07/01/2022 - "In the present study, the effects and possible underlying mechanisms of CysLTR antagonists (pranlukast and HAMI 3379) on SP meningitis were further determined. "
3.	Brain Ischemia (Cerebral Ischemia) 11/12/2012 - "Here, we determined whether HAMI 3379, a selective CysLT(2)R antagonist, protects against acute brain injury after focal cerebral ischemia in rats. " 04/16/2015 - "We have reported that CysLT2R is involved in neuronal injury, astrocytosis, and microgliosis, and that intracerebroventricular (i.c.v.) injection of the selective CysLT2R antagonist HAMI 3379 protects against acute brain injury after focal cerebral ischemia in rats. " 04/16/2015 - "HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats." 11/12/2012 - "Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats." 01/01/2018 - ": CysLTR antagonists Pranlukast and HAMI 3379 have long-term neuroprotective effect on chronic brain injury induced by global cerebral ischemia/reperfusion in gerbils."
4.	Ischemia 01/01/2018 - "After ischemia, the CysLTR antagonists Pranlukast (0.1 mg/kg) and HAMI 3379 (0.1 mg/kg) were injected intraperitoneally for 5 consecutive days in the last two groups,while the former two groups were injected with saline only (10 mL/kg). " 08/01/2013 - "HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation."
5.	Gliosis 07/01/2022 - "Furthermore, pranlukast and HAMI 3379 treatment ameliorated neuronal injury and inhibited microgliosis and astrogliosis. " 04/16/2015 - "We have reported that CysLT2R is involved in neuronal injury, astrocytosis, and microgliosis, and that intracerebroventricular (i.c.v.) injection of the selective CysLT2R antagonist HAMI 3379 protects against acute brain injury after focal cerebral ischemia in rats. "

Related Drugs and Biologics

1.	Inflammasomes
2.	pranlukast
3.	cysteinyl leukotriene receptor 2
4.	Neuroprotective Agents
5.	Immunoglobulin G (IgG)
6.	Dihydrotachysterol (AT 10)