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8- (bis(2- chlorophenyl)methyl)- 3- (2- pyrimidinyl)- 8- azabicyclo(3.2.1)octan- 3- ol

a cough suppressant and nociceptin/orphanin FQ peptide (NOP) receptor agonist; structure in first source

Also Known As:

SCH 486757; SCH-486757; SCH486757

Networked: 3 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 8-(bis(2-chlorophenyl)methyl)-3-(2-pyrimidinyl)-8-azabicyclo(3.2.1)octan-3-ol: 3
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - 8-(bis(2-chlorophenyl)methyl)-3-(2-pyrimidinyl)-8-azabicyclo(3.2.1)octan-3-ol: 3
Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - 8-(bis(2-chlorophenyl)methyl)-3-(2-pyrimidinyl)-8-azabicyclo(3.2.1)octan-3-ol: 3

Experts

1.	McLeod, Robbie L: 3 articles (01/2011 - 01/2010)
2.	Sadeh, Jonathan: 2 articles (01/2011 - 01/2010)
3.	Tulshian, Deen B: 2 articles (01/2011 - 03/2010)
4.	Austin, Theodore M: 1 article (03/2010)
5.	Baptista, Marco: 1 article (03/2010)
6.	Bolser, Donald C: 1 article (03/2010)
7.	Erickson, Christine H: 1 article (03/2010)
8.	Fawzi, Ahmad B: 1 article (03/2010)
9.	Fernandez, Xiomara: 1 article (03/2010)
10.	Hey, John A: 1 article (03/2010)

Related Diseases

1.

01/01/2010 - "The efficacy of a NOP1 agonist (SCH486757) in subacute cough."
01/01/2011 - "Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757."
03/25/2010 - "In a feline mechanically-evoked cough model, SCH 486757 produces a maximum inhibition of cough and expiratory abdominal electromyogram amplitude of 59 and 61%, respectively. "
03/25/2010 - "Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models."
01/01/2010 - "Therefore, we compared the effect of NOP1 receptor agonist SCH486757 with matched placebo and codeine in a multicentre, double-blind, parallel-group study in patients with subacute cough. "

Related Drugs and Biologics

1.	Codeine (Codeine Phosphate)
2.	Peptides (Polypeptides)
3.	Nociceptin
4.	Hydrocodone (Dihydrocodeinone)
5.	Dextromethorphan (Racemethorphan)
6.	Capsaicin (Zostrix)
7.	Baclofen

Related Therapies and Procedures

1.	Oral Administration