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5-aminoisoquinoline

PARP-1 inhibitor for genotoxicity potential; structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 5-aminoisoquinoline: 2

Experts

1.	Caba-Molina, Mercedes: 1 article (01/2018)
2.	González, Juan Francisco: 1 article (01/2018)
3.	Gómez-Morales, Mercedes: 1 article (01/2018)
4.	Montoro-Molina, Sebastián: 1 article (01/2018)
5.	O'Valle, Francisco: 1 article (01/2018)
6.	Osuna, Antonio: 1 article (01/2018)
7.	Quesada, Andrés: 1 article (01/2018)
8.	Vargas, Félix: 1 article (01/2018)
9.	Wangensteen, Rosemary: 1 article (01/2018)
10.	de Gracia, María C: 1 article (01/2018)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 01/01/2018 - "5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats." 01/01/2018 - "The aim of the present study is to analyze the effects of 5-aminoisoquinoline (5-AIQ), a poly(ADP-ribose) polymerase-1 (PARP1) inhibitor, over renal dysfunction and fibrosis during recovery phase of cisplatin (CisPt)-induced acute kidney injury (AKI) in rats. "
2.	Cardiomegaly (Heart Hypertrophy) 12/01/2006 - "On the other hand, treatment with 5-aminoisoquinoline did not modulate CST-induced physiological cardiac hypertrophy. " 12/01/2006 - "The present study was designed to investigate the effect of 5-aminoisoquinoline, a specific poly(ADP-ribose) polymerase (PARP) inhibitor, in partial abdominal aortic constriction (PAAC) for 4 weeks it induced pathological and chronic swimming training (CST) for 8 weeks it induced physiological cardiac hypertrophy. "
3.	Fibrosis (Cirrhosis) 01/01/2018 - "5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats." 01/01/2018 - "The aim of the present study is to analyze the effects of 5-aminoisoquinoline (5-AIQ), a poly(ADP-ribose) polymerase-1 (PARP1) inhibitor, over renal dysfunction and fibrosis during recovery phase of cisplatin (CisPt)-induced acute kidney injury (AKI) in rats. "
4.	Left Ventricular Dysfunction 12/01/2006 - "The 5-aminoisoquinoline, a potent selective inhibitor of PARP, significantly attenuated PAAC-induced LV dysfunction, LV hypertrophy, increase in VP and MABP. "
5.	Hypertrophy 12/01/2006 - "The 5-aminoisoquinoline, a potent selective inhibitor of PARP, significantly attenuated PAAC-induced LV dysfunction, LV hypertrophy, increase in VP and MABP. "

Related Drugs and Biologics

1.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2.	Cisplatin (Platino)
3.	Poly (ADP-Ribose) Polymerase-1
4.	Poly(ADP-ribose) Polymerase Inhibitors