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2- (8- (3,5- difluorophenyl)- 10- oxo- 6,9- diazaspiro(4.5)dec- 9- yl)- N- (2'- oxo- 1,1',2',3- tetrahydrospiro(indene- 2,3'- pyrrolo(2,3- b)pyridin)- 5- yl)acetamide

structure in first source

Also Known As:

MK 3207; MK-3207; MK3207

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide: 6
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide: 6
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - 2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide: 6

Experts

1.	Goadsby, Peter J: 3 articles (01/2020 - 04/2011)
2.	Baek, In-Hwan: 1 article (09/2022)
3.	Han, Nayoung: 1 article (09/2022)
4.	Lee, Seoyeon: 1 article (09/2022)
5.	Staatz, Christine E: 1 article (09/2022)
6.	Ashina, Messoud: 1 article (01/2020)
7.	Rowe, Josh: 1 article (01/2020)
8.	Sistare, Frank D: 1 article (01/2020)
9.	Smith, Brenda: 1 article (01/2020)
10.	Watkins, Paul B: 1 article (01/2020)

Related Diseases

1.	Migraine Disorders (Migraine) 04/01/2011 - "MK-3207 was effective and generally well tolerated in the acute treatment of migraine." 04/01/2011 - "Migraine patients were initially randomized to MK-3207 2.5, 5, 10, 20, 50 and 100 mg or placebo to treat a moderate/severe migraine. " 04/01/2011 - "This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment of migraine. " 04/01/2011 - "Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine." 05/01/2015 - "We sought to evaluate a CGRP receptor antagonist, MK-3207, in the biomarker model and to assess the predictability of the CIDV response to migraine clinical efficacy. "
2.	Chemical and Drug Induced Liver Injury 01/01/2020 - "However, previously investigated CGRP receptor antagonists, telcagepant and MK-3207, were discontinued during clinical development because of concerns about drug-induced liver injury. "
3.	Pain (Aches) 04/01/2011 - "A positive dose-response trend was demonstrated when data were combined across all MK-3207 doses for two-hour pain freedom (p < .001). "

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