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N- (2- naphthalenyl)- ((3,5- dibromo- 2,4- dihydroxyphenyl)methylene)glycine hydrazide

a cystic fibrosis transmembrane regulator inhibitor

Also Known As:

GlyH-101

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide: 4
Organic Chemicals: 133
- Hydrazines: 379
  - N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide: 4

Experts

1.	Bouillaud, Frederick: 1 article (04/2010)
2.	Brouillard, Franck: 1 article (04/2010)
3.	Colas, Julien: 1 article (04/2010)
4.	Edelman, Aleksander: 1 article (04/2010)
5.	Fritsch, Janine: 1 article (04/2010)
6.	Kelly, Mairead: 1 article (04/2010)
7.	Nguyen-Khoa, Thao: 1 article (04/2010)
8.	Ollero, Mario: 1 article (04/2010)
9.	Trudel, Stephanie: 1 article (04/2010)
10.	Prante, Christian: 1 article (01/2010)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2023 - "Human colon HT-29 cancer cells were treated with GlyH-101 or CaCCinh-A01 or GlyH-101 plus CaCCinh-A01 complex. " 08/01/2023 - "Available evidence suggests that GlyH-101 and CaCCinh-A01 can suppress cell proliferation, block invasion and metastasis, and cause several cancer cell types to undergo apoptosis, demonstrating their anti-tumor properties. "
2.	Neoplasm Metastasis (Metastasis) 08/01/2023 - "Available evidence suggests that GlyH-101 and CaCCinh-A01 can suppress cell proliferation, block invasion and metastasis, and cause several cancer cell types to undergo apoptosis, demonstrating their anti-tumor properties. "
3.	Necrosis 08/01/2023 - "Treatment with GlyH-101 and CaCCinh-A01 resulted in cell necrosis and apoptosis, up-regulated ROS levels, activated the mitochondrial apoptosis pathway, prompted arrest of the cell cycle in S phase, and increased the levels of proteins related to the cell cycle. "
4.	Cystic Fibrosis (Mucoviscidosis) 04/01/2010 - "Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]- 2-thioxo-4-thiazolidinone] and the glycine hydrazide GlyH-101 [N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide]. " 04/01/2010 - "Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition."
5.	Cholera 08/01/2004 - "In a closed-loop model of cholera, intraluminal GlyH-101 (2.5 microg) reduced by approximately 80% cholera toxin-induced intestinal fluid secretion. "

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	Proteins (Proteins, Gene)
3.	Hyaluronic Acid (Hyaluronan)
4.	Cholera Toxin
5.	3- ((3- trifluoromethyl)phenyl)- 5- ((3- carboxyphenyl)methylene)- 2- thioxo- 4- thiazolidinone
6.	glycine hydrazide
7.	6- t- butyl- 2- (furan- 2- carboxamido)- 4,5,6,7- tetrahydrobenzo(b)thiophene- 3- carboxylic acid