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LP533401

Serotonin Agents; Tryptophan Hydroxylase inhibitor; structure in first source

Networked: 10 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - LP533401: 10

Experts

1.	Domaniewski, Tomasz: 3 articles (08/2020 - 01/2018)
2.	Pawlak, Dariusz: 3 articles (08/2020 - 01/2018)
3.	Pawlak, Krystyna: 3 articles (08/2020 - 01/2018)
4.	Shang, Jing: 3 articles (01/2020 - 01/2019)
5.	Kalaska, Bartlomiej: 2 articles (08/2020 - 01/2018)
6.	Kalavagunta, Praveen Kumar: 2 articles (03/2019 - 01/2019)
7.	Znorko, Beata: 2 articles (01/2019 - 01/2018)
8.	Cylwik, Bogdan: 1 article (08/2020)
9.	Mor, Adrian: 1 article (08/2020)
10.	Sieklucka, Beata: 1 article (08/2020)

Related Diseases

1.	Chronic Renal Insufficiency 01/01/2019 - "Recently, we showed that treatment with LP533401 improved bone health in rats with chronic kidney disease (CKD) via the normalization of serum phosphate resulting from the reduced renal expression of phosphate cotransporters, including Klotho. " 08/19/2020 - "Modulation of the Paracrine Kynurenic System in Bone as a New Regulator of Osteoblastogenesis and Bone Mineral Status in an Animal Model of Chronic Kidney Disease Treated with LP533401."
2.	Periodontitis 10/01/2016 - "In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. "
3.	Non-alcoholic Fatty Liver Disease 01/01/2020 - "The serum 5-HT levels in patients with non-alcoholic fatty liver disease (NAFLD) and a rat fed with high fat-sucrose diet (HFSD) were evaluated using liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF MS)/MS. The peripheral Tph1 inhibitor, LP533401, and a tryptophan (TRP)-free diet were administered to rats with NASH, induced by HFSD. "
4.	Glucose Intolerance 01/01/2019 - "LP533401 and SIM could significantly improve the impaired glucose tolerance, while BZ had no significant effect. "
5.	Uremia 01/01/2018 - "We tested the hypothesis that treatment with LP533401 could reverse CKD-induced bone loss in uremia. "

Related Drugs and Biologics

1.	Phosphates (Orthophosphate)
2.	Serotonin (5 Hydroxytryptamine)
3.	Prescription Drugs
4.	Citalopram
5.	Vitamin D
6.	Tryptophan (L-Tryptophan)
7.	Sucrose (Saccharose)
8.	Proteins (Proteins, Gene)
9.	Minerals
10.	Calcium

Related Therapies and Procedures

1.	Ligation